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Database: UniProt
Entry: D6M397_STRSH
LinkDB: D6M397_STRSH
Original site: D6M397_STRSH 
ID   D6M397_STRSH            Unreviewed;       632 AA.
AC   D6M397;
DT   13-JUL-2010, integrated into UniProtKB/TrEMBL.
DT   13-JUL-2010, sequence version 1.
DT   27-SEP-2017, entry version 42.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=SSBG_05773 {ECO:0000313|EMBL:EFG64970.2};
OS   Streptomyces sp. (strain SPB074).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=465543 {ECO:0000313|EMBL:EFG64970.2, ECO:0000313|Proteomes:UP000002779};
RN   [1] {ECO:0000313|Proteomes:UP000002779}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SPB074 {ECO:0000313|Proteomes:UP000002779};
RG   The Broad Institute Genome Sequencing Platform;
RA   Fischbach M., Ward D., Young S., Jaffe D., Gnerre S., Berlin A.,
RA   Heiman D., Hepburn T., Sykes S., Alvarado L., Kodira C.D.,
RA   Straight P., Clardy J., Hung D., Kolter R., Mekalanos J., Walker S.,
RA   Walsh C.T., Lander E., Galagan J., Nusbaum C., Birren B.;
RL   Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:EFG64970.2, ECO:0000313|Proteomes:UP000002779}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SPB074 {ECO:0000313|Proteomes:UP000002779};
RG   The Broad Institute Genome Sequencing Platform;
RG   Broad Institute Microbial Sequencing Center;
RA   Fischbach M., Godfrey P., Ward D., Young S., Zeng Q., Koehrsen M.,
RA   Alvarado L., Berlin A.M., Bochicchio J., Borenstein D., Chapman S.B.,
RA   Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J., Griggs A.,
RA   Gujja S., Heilman E.R., Heiman D.I., Hepburn T.A., Howarth C., Jen D.,
RA   Larson L., Lewis B., Mehta T., Park D., Pearson M., Richards J.,
RA   Roberts A., Saif S., Shea T.D., Shenoy N., Sisk P., Stolte C.,
RA   Sykes S.N., Thomson T., Walk T., White J., Yandava C., Straight P.,
RA   Clardy J., Hung D., Kolter R., Mekalanos J., Walker S., Walsh C.T.,
RA   Wieland-Brown L.C., Haas B., Nusbaum C., Birren B.;
RT   "The genome sequence of Streptomyces sp. strain SPB74.";
RL   Submitted (OCT-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731907}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
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DR   EMBL; GG770539; EFG64970.2; -; Genomic_DNA.
DR   ProteinModelPortal; D6M397; -.
DR   EnsemblBacteria; EFG64970; EFG64970; SSBG_05773.
DR   OrthoDB; POG091H02FF; -.
DR   Proteomes; UP000002779; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731922};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002779};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731897};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002779}.
FT   DOMAIN      332    460       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      546    611       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     340    347       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   632 AA;  70869 MW;  BEFF5D17D885D15E CRC64;
     MEGRLAPVVS ETLSRECGRP IRIAITVDES MGDAPAAPRY EEPVPVPRPR FEEPAQPRYD
     SQDRYESQER YEQIEAQTLY EPPIERGPTV RPVYHEYQAP GSWPRVREDY GWQQQRLGYA
     ESDAYGQGGR GDYRQAPAER PPYEQQDGRE GRDERYEQPE RGERSERPDR FDAGDRYEPG
     ERYESGERYE QDRAPERYEQ DRSAYEQPRG TYEKPGARGG YGRGYEKAGA REEVRGYEEH
     GSGEQRERGE EAARPGRQRG QGGVSLPAQG GPSLAPSGAP GPLAAQPAPA AGPGEPTARL
     NPKYLFDTFV IGASNRFAHA AAVAVAEAPA KAYNPLFVYG ESGLGKTHLL HAIGHYARSL
     YPGTRVRYVS SEEFTNEFIN SIRDGKGDSF RKRYREMDIL LVDDIQFLAD KESTQEEFFH
     TFNTLHNANK QIVLSSDRPP KQLVTLEDRL RNRFEWGLIT DVQPPELETR IAILRKKAVQ
     EQLNAPPEVL EFIASRISRN IRELEGALIR VTAFASLNRQ PVDLGLTEIV LKDLIPGGED
     ASPEITASAI MSATADYFGQ TVEDLCGSSR SRVLVTARQI AMYLCRELTD LSLPKIGAQF
     GGRDHTTVMH VLPEDCRADG GLFARSTTRS RN
//
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