ID D6NF16_MEGAM Unreviewed; 643 AA.
AC D6NF16;
DT 13-JUL-2010, integrated into UniProtKB/TrEMBL.
DT 13-JUL-2010, sequence version 1.
DT 24-JAN-2024, entry version 59.
DE SubName: Full=Hypoxia-inducible factor 3 alpha {ECO:0000313|EMBL:ADF50045.1};
GN Name=HIF-3alpha {ECO:0000313|EMBL:ADF50045.1};
OS Megalobrama amblycephala (Chinese blunt snout bream) (Brema carp).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Xenocyprididae; Xenocypridinae; Megalobrama.
OX NCBI_TaxID=75352 {ECO:0000313|EMBL:ADF50045.1};
RN [1] {ECO:0000313|EMBL:ADF50045.1}
RP NUCLEOTIDE SEQUENCE.
RA Zou S., Shen R., Jiang X.;
RT "Megalobrama amblycephala hif-1a, -2a and -3a genes: cDNA cloning,
RT expression, and their different responses to hypoxia.";
RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; GU363500; ADF50045.1; -; mRNA.
DR AlphaFoldDB; D6NF16; -.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:InterPro.
DR GO; GO:0005667; C:transcription regulator complex; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR CDD; cd00130; PAS; 2.
DR Gene3D; 3.30.450.20; PAS domain; 2.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR021537; HIF_alpha-like.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR001067; Nuc_translocat.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013767; PAS_fold.
DR NCBIfam; TIGR00229; sensory_box; 1.
DR PANTHER; PTHR23043; HYPOXIA-INDUCIBLE FACTOR 1 ALPHA; 1.
DR PANTHER; PTHR23043:SF34; HYPOXIA-INDUCIBLE FACTOR 1 SUBUNIT ALPHA,-LIKE; 1.
DR Pfam; PF11413; HIF-1; 1.
DR Pfam; PF00989; PAS; 1.
DR Pfam; PF14598; PAS_11; 1.
DR PRINTS; PR00785; NCTRNSLOCATR.
DR SMART; SM00353; HLH; 1.
DR SMART; SM00091; PAS; 2.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 2.
DR PROSITE; PS50888; BHLH; 1.
DR PROSITE; PS50112; PAS; 2.
PE 2: Evidence at transcript level;
KW Hydroxylation {ECO:0000256|ARBA:ARBA00023278};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT DOMAIN 13..66
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT DOMAIN 92..146
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 249..291
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT REGION 358..389
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 366..386
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 643 AA; 72515 MW; 7BBF3BAC06D1C354 CRC64;
MVNSVIKRPS LEQRKVRSRD AARCRRSQET EVFYELAHSL PLPRRITSHL DKAAIMRVTL
SYLRMNRLIQ SVGPTKTKTE ETENPTDGFY QQALAGFILV MTEEGDMIFL SESVSKYIGI
TQLELLGQSV YEFVHPCDQE ELRDILTTRP GISKKKTEKL AEHNFFLRMK STLTHTGRTV
NIKSANWKVL HCTGHMQTFS GDDESSLPAG SFLTLLCEPI PHPSSVEFPL DSSTFLTRHS
MDLTFTQCDG RVTELVGYQP DDLIGRSAYE FYHALDFDHV TRSLHILFSK GQVCTSHYRF
LAKNGGFIWT ETQATVLYNS RTSQPEAVVC LNFILSGVEE ADVVFSLEQT CQKPKPKAEK
LSVLEKVEEE EEEEEEEEEE EDSDMDESST AKLFLQMKEN PEELMQLAPH SGDAIISLRE
GVELSFCRPS SPNSVPECPQ DLCTPELRQL LSPIFDRPTK SPPAASPAEE LPMEMEGVEK
FFALKPEESV TLKGQSEAMD EIDLDMLAPY ISMDDDFQLT FLPQSEMAAS SEMLTNSSRK
RCLEDEEEDD IPVLAAKWER KQMSSSIEEQ LLLSHTLLNG LSDDASEEFE PPPQKRCQLL
TDRDPLLGGA QALCDTAALM KDTFLSRPPD LMRPVAETMS SLT
//