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Database: UniProt
Entry: D6NF16_MEGAM
LinkDB: D6NF16_MEGAM
Original site: D6NF16_MEGAM 
ID   D6NF16_MEGAM            Unreviewed;       643 AA.
AC   D6NF16;
DT   13-JUL-2010, integrated into UniProtKB/TrEMBL.
DT   13-JUL-2010, sequence version 1.
DT   24-JAN-2024, entry version 59.
DE   SubName: Full=Hypoxia-inducible factor 3 alpha {ECO:0000313|EMBL:ADF50045.1};
GN   Name=HIF-3alpha {ECO:0000313|EMBL:ADF50045.1};
OS   Megalobrama amblycephala (Chinese blunt snout bream) (Brema carp).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Xenocyprididae; Xenocypridinae; Megalobrama.
OX   NCBI_TaxID=75352 {ECO:0000313|EMBL:ADF50045.1};
RN   [1] {ECO:0000313|EMBL:ADF50045.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Zou S., Shen R., Jiang X.;
RT   "Megalobrama amblycephala hif-1a, -2a and -3a genes: cDNA cloning,
RT   expression, and their different responses to hypoxia.";
RL   Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR   EMBL; GU363500; ADF50045.1; -; mRNA.
DR   AlphaFoldDB; D6NF16; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0005634; C:nucleus; IEA:InterPro.
DR   GO; GO:0005667; C:transcription regulator complex; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   CDD; cd00130; PAS; 2.
DR   Gene3D; 3.30.450.20; PAS domain; 2.
DR   InterPro; IPR011598; bHLH_dom.
DR   InterPro; IPR021537; HIF_alpha-like.
DR   InterPro; IPR036638; HLH_DNA-bd_sf.
DR   InterPro; IPR001067; Nuc_translocat.
DR   InterPro; IPR000014; PAS.
DR   InterPro; IPR035965; PAS-like_dom_sf.
DR   InterPro; IPR013767; PAS_fold.
DR   NCBIfam; TIGR00229; sensory_box; 1.
DR   PANTHER; PTHR23043; HYPOXIA-INDUCIBLE FACTOR 1 ALPHA; 1.
DR   PANTHER; PTHR23043:SF34; HYPOXIA-INDUCIBLE FACTOR 1 SUBUNIT ALPHA,-LIKE; 1.
DR   Pfam; PF11413; HIF-1; 1.
DR   Pfam; PF00989; PAS; 1.
DR   Pfam; PF14598; PAS_11; 1.
DR   PRINTS; PR00785; NCTRNSLOCATR.
DR   SMART; SM00353; HLH; 1.
DR   SMART; SM00091; PAS; 2.
DR   SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR   SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 2.
DR   PROSITE; PS50888; BHLH; 1.
DR   PROSITE; PS50112; PAS; 2.
PE   2: Evidence at transcript level;
KW   Hydroxylation {ECO:0000256|ARBA:ARBA00023278};
KW   Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT   DOMAIN          13..66
FT                   /note="BHLH"
FT                   /evidence="ECO:0000259|PROSITE:PS50888"
FT   DOMAIN          92..146
FT                   /note="PAS"
FT                   /evidence="ECO:0000259|PROSITE:PS50112"
FT   DOMAIN          249..291
FT                   /note="PAS"
FT                   /evidence="ECO:0000259|PROSITE:PS50112"
FT   REGION          358..389
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        366..386
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   643 AA;  72515 MW;  7BBF3BAC06D1C354 CRC64;
     MVNSVIKRPS LEQRKVRSRD AARCRRSQET EVFYELAHSL PLPRRITSHL DKAAIMRVTL
     SYLRMNRLIQ SVGPTKTKTE ETENPTDGFY QQALAGFILV MTEEGDMIFL SESVSKYIGI
     TQLELLGQSV YEFVHPCDQE ELRDILTTRP GISKKKTEKL AEHNFFLRMK STLTHTGRTV
     NIKSANWKVL HCTGHMQTFS GDDESSLPAG SFLTLLCEPI PHPSSVEFPL DSSTFLTRHS
     MDLTFTQCDG RVTELVGYQP DDLIGRSAYE FYHALDFDHV TRSLHILFSK GQVCTSHYRF
     LAKNGGFIWT ETQATVLYNS RTSQPEAVVC LNFILSGVEE ADVVFSLEQT CQKPKPKAEK
     LSVLEKVEEE EEEEEEEEEE EDSDMDESST AKLFLQMKEN PEELMQLAPH SGDAIISLRE
     GVELSFCRPS SPNSVPECPQ DLCTPELRQL LSPIFDRPTK SPPAASPAEE LPMEMEGVEK
     FFALKPEESV TLKGQSEAMD EIDLDMLAPY ISMDDDFQLT FLPQSEMAAS SEMLTNSSRK
     RCLEDEEEDD IPVLAAKWER KQMSSSIEEQ LLLSHTLLNG LSDDASEEFE PPPQKRCQLL
     TDRDPLLGGA QALCDTAALM KDTFLSRPPD LMRPVAETMS SLT
//
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