ID D6NVL0_9HIV1 Unreviewed; 840 AA.
AC D6NVL0;
DT 13-JUL-2010, integrated into UniProtKB/TrEMBL.
DT 13-JUL-2010, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE RecName: Full=Envelope glycoprotein gp160 {ECO:0000256|ARBA:ARBA00015406};
DE AltName: Full=Env polyprotein {ECO:0000256|ARBA:ARBA00029888};
DE Flags: Fragment;
GN Name=env {ECO:0000313|EMBL:ADF84389.1};
OS Human immunodeficiency virus 1.
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX NCBI_TaxID=11676 {ECO:0000313|EMBL:ADF84389.1};
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1] {ECO:0000313|EMBL:ADF84389.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=G1514TOB8U {ECO:0000313|EMBL:ADF84389.1};
RX PubMed=20231689; DOI=10.4049/jimmunol.0903745;
RA John M., Heckerman D., James I., Park L.P., Carlson J.M., Chopra A.,
RA Gaudieri S., Nolan D., Haas D.W., Riddler S.A., Haubrich R., Mallal S.;
RT "Adaptive interactions between HLA and HIV-1: highly divergent selection
RT imposed by HLA class I molecules with common supertype motifs.";
RL J. Immunol. 184:4368-4377(2010).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004202};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004202}. Cell
CC membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004251}. Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004481}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004481}. Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004530}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004530}. Host cell membrane
CC {ECO:0000256|ARBA:ARBA00004505}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004505}. Host cell membrane
CC {ECO:0000256|ARBA:ARBA00004402}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004402}. Host endosome membrane
CC {ECO:0000256|ARBA:ARBA00004433}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004433}. Host endosome membrane
CC {ECO:0000256|ARBA:ARBA00004578}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004578}. Membrane
CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479}. Virion membrane
CC {ECO:0000256|ARBA:ARBA00004650}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004650}. Virion membrane
CC {ECO:0000256|ARBA:ARBA00004563}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004563}.
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DR EMBL; GU728363; ADF84389.1; -; Genomic_RNA.
DR GO; GO:0044175; C:host cell endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR Gene3D; 1.10.287.210; -; 1.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 2.170.40.20; Human immunodeficiency virus 1, Gp160, envelope glycoprotein; 3.
DR Gene3D; 1.20.5.490; Single helix bin; 1.
DR InterPro; IPR036377; Gp120_core_sf.
DR InterPro; IPR000328; GP41-like.
DR InterPro; IPR000777; HIV1_Gp120.
DR Pfam; PF00516; GP120; 2.
DR Pfam; PF00517; GP41; 2.
DR SUPFAM; SSF56502; gp120 core; 3.
DR SUPFAM; SSF58069; Virus ectodomain; 1.
PE 4: Predicted;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Host cell membrane {ECO:0000256|ARBA:ARBA00022511};
KW Host endosome {ECO:0000256|ARBA:ARBA00023046};
KW Host membrane {ECO:0000256|ARBA:ARBA00022870};
KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022581};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Viral envelope protein {ECO:0000313|EMBL:ADF84389.1};
KW Virion {ECO:0000313|EMBL:ADF84389.1}.
FT TRANSMEM 662..689
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 18..336
FT /note="Human immunodeficiency virus 1 envelope glycoprotein
FT Gp120"
FT /evidence="ECO:0000259|Pfam:PF00516"
FT DOMAIN 452..496
FT /note="Human immunodeficiency virus 1 envelope glycoprotein
FT Gp120"
FT /evidence="ECO:0000259|Pfam:PF00516"
FT DOMAIN 514..567
FT /note="Retroviral envelope protein GP41-like"
FT /evidence="ECO:0000259|Pfam:PF00517"
FT DOMAIN 612..703
FT /note="Retroviral envelope protein GP41-like"
FT /evidence="ECO:0000259|Pfam:PF00517"
FT REGION 702..726
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 711..726
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ADF84389.1"
SQ SEQUENCE 840 AA; 94340 MW; DC6E04CA0CFE491E CRC64;
WGTLLLGILM ICSASDKLWV TVYYGVPVWK EATTTLFCAS DAKAVETEAH NVWATHACVP
TDPNPQEIXL ANVTEDFNMW KNTMVDQMHE DIISLWDQSL KPCVKLTPLC VTLNCTNWNS
TSTNSSNTGX ITMKIGTGEI KNCSFNITTN XRDKIQRQYA LFNSLDVVPI EDDNTSYRLL
SCNTSVLTQA CPKLSFEPIP IHYCAPAGFA ILKCNNKTFN GKGPCNNVST VQCTHGIRPV
VSTQLLLNGS LAEEEVVIRS DNFSDNTKNI IVQLKTPVQI NCTRPNNNTR KSINIGPGRA
FFATGEITGD IRQAHCNISK GNWTKTLGQV AEKLXXXXXX XXXXXXXXXX XXXXXXXXXX
XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX
XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX ETFRPGGGNM RDNWRSELYK YKVVKIEPLG
IAPTKARRRV VHREKRAALG AVILGFLGAA GSTMGAASVT LTVQARLLLS GIVQQQSNLL
RAIEAQQHML QLTVWGIKQL QARVLAXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX
XXXXXXXXNM TWMQWEREID NYTQTIYTLI EESQNQQEKN EXXLLALDKW ANLWNWFSIS
NWLWYIRIFI MIIGGLVGLR IVFAVLSIVN RVRKGYSPLS FQTHLPTPRG PDRPEGIEGD
GGERDREGSR LLVDGFLTLI WVDLRSLCLF SYHRLRDLLL IVTRTVELLG RRGWEALKYC
WNLLLYWXQE LKNSAISLLN ATAIAVAEGT DRIXEVAQRX GRAILHIPRR IRQGFERALL
//
