ID D6RH31_HUMAN Unreviewed; 609 AA.
AC D6RH31;
DT 13-JUL-2010, integrated into UniProtKB/TrEMBL.
DT 13-JUL-2010, sequence version 1.
DT 27-MAR-2024, entry version 95.
DE SubName: Full=Nephronectin {ECO:0000313|Ensembl:ENSP00000426146.1};
DE Flags: Fragment;
GN Name=NPNT {ECO:0000313|Ensembl:ENSP00000426146.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000426146.1, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000426146.1, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [2] {ECO:0000313|Ensembl:ENSP00000426146.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the nephronectin family.
CC {ECO:0000256|ARBA:ARBA00009738}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; AC093782; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC109361; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; D6RH31; -.
DR SMR; D6RH31; -.
DR MassIVE; D6RH31; -.
DR PeptideAtlas; D6RH31; -.
DR ProteomicsDB; 14797; -.
DR Antibodypedia; 1021; 144 antibodies from 23 providers.
DR Ensembl; ENST00000503451.5; ENSP00000426146.1; ENSG00000168743.13.
DR UCSC; uc062yue.1; human.
DR HGNC; HGNC:27405; NPNT.
DR VEuPathDB; HostDB:ENSG00000168743; -.
DR GeneTree; ENSGT00930000150973; -.
DR PhylomeDB; D6RH31; -.
DR ChiTaRS; NPNT; human.
DR Proteomes; UP000005640; Chromosome 4.
DR Bgee; ENSG00000168743; Expressed in right lobe of thyroid gland and 166 other cell types or tissues.
DR ExpressionAtlas; D6RH31; baseline and differential.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR CDD; cd00054; EGF_CA; 2.
DR CDD; cd06263; MAM; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 2.10.25.10; Laminin; 5.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR024731; EGF_dom.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR000998; MAM_dom.
DR PANTHER; PTHR24050:SF19; NEPHRONECTIN; 1.
DR PANTHER; PTHR24050; PA14 DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF12947; EGF_3; 1.
DR Pfam; PF07645; EGF_CA; 2.
DR Pfam; PF00629; MAM; 1.
DR SMART; SM00181; EGF; 5.
DR SMART; SM00179; EGF_CA; 3.
DR SMART; SM00137; MAM; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 3.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS01186; EGF_2; 3.
DR PROSITE; PS50026; EGF_3; 3.
DR PROSITE; PS01187; EGF_CA; 1.
DR PROSITE; PS50060; MAM_2; 1.
PE 1: Evidence at protein level;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW Proteomics identification {ECO:0007829|MaxQB:D6RH31,
KW ECO:0007829|PeptideAtlas:D6RH31};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..609
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003087444"
FT DOMAIN 136..175
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 216..260
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 261..301
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 467..609
FT /note="MAM"
FT /evidence="ECO:0000259|PROSITE:PS50060"
FT REGION 348..436
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 362..395
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 609
FT /evidence="ECO:0000313|Ensembl:ENSP00000426146.1"
SQ SEQUENCE 609 AA; 66916 MW; 0E54C2FDA351B1A7 CRC64;
MDFLLALVLV SSLYLQAAAE FDGRWPRQIV SSIGLCRYGG RIDCCWGWAR QSWGQCQPFY
VLRQRIARIR CQLKAVCQPR CKHGECIGPN KCKCHPGYAG KTCNQDEHIP APLDQGSEQP
LFQPLDHQAT SLPSRDLNEC GLKPRPCKHR CMNTYGSYKC YCLNGYMLMP DGSCSSALTC
SMANCQYGCD VVKGQIRCQC PSPGLQLAPD GRTCVDVDEC ATGRASCPRF RQCVNTFGSY
ICKCHKGFDL MYIGGKYQCH DIDECSLGQY QCSSFARCYN IRGSYKCKCK EGYQGDGLTC
VYIPKVMIEP SGPIHVPKGN GTILKGDTGN NNWIPDVGST WWPPKTPYIP PIITNRPTSK
PTTRPTPKPT PIPTPPPPPP LPTELRTPLP PTTPERPTTG LTTIAPAAST PPGGITVDNR
VQTDPQKPRG DVFIPRQPSN DLFEIFEIER GVSADDEAKD DPGVLVHSCN FDHGLCGWIR
EKDNDLHWEP IRDPAGGQYL TVSAAKAPGG KAARLVLPLG RLMHSGDLCL SFRHKVTGLH
SGTLQVFVRK HGAHGAALWG RNGGHGWRQT QITLRGADIK SVVFKGEKRR GHTGEIGLDD
VSLKKGHCS
//
