ID D6RV40_HERJA Unreviewed; 385 AA.
AC D6RV40;
DT 10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT 10-AUG-2010, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=protein-synthesizing GTPase {ECO:0000256|ARBA:ARBA00011986};
DE EC=3.6.5.3 {ECO:0000256|ARBA:ARBA00011986};
DE Flags: Fragment;
GN Name=EIF2S3Y {ECO:0000313|EMBL:BAJ08423.1};
OS Herpestes javanicus (Small Indian mongoose) (Urva javanica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Herpestidae; Urva.
OX NCBI_TaxID=140016 {ECO:0000313|EMBL:BAJ08423.1};
RN [1] {ECO:0000313|EMBL:BAJ08423.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Brain {ECO:0000313|EMBL:BAJ08423.1};
RA Murata C., Ogura G., Kuroiwa A.;
RT "A primer set to determine sex in the small Indian mongoose, Herpestes
RT auropunctatus.";
RL Mol. Ecol. Resour. 11:386-388(2011).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; EC=3.6.5.3;
CC Evidence={ECO:0000256|ARBA:ARBA00001874};
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DR EMBL; AB550793; BAJ08423.1; -; mRNA.
DR AlphaFoldDB; D6RV40; -.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR GO; GO:0000049; F:tRNA binding; IEA:InterPro.
DR CDD; cd01888; eIF2_gamma; 1.
DR CDD; cd03688; eIF2_gamma_II; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 2.
DR InterPro; IPR004161; EFTu-like_2.
DR InterPro; IPR015256; eIF2g_C.
DR InterPro; IPR044127; eIF2g_dom_2.
DR InterPro; IPR044128; eIF2g_GTP-bd.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR009001; Transl_elong_EF1A/Init_IF2_C.
DR PANTHER; PTHR42854; EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 3 FAMILY MEMBER; 1.
DR PANTHER; PTHR42854:SF18; PROTEIN-SYNTHESIZING GTPASE; 1.
DR Pfam; PF09173; eIF2_C; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF03144; GTP_EFTU_D2; 1.
DR SUPFAM; SSF50465; EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR PROSITE; PS51722; G_TR_2; 1.
PE 2: Evidence at transcript level;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Initiation factor {ECO:0000256|ARBA:ARBA00022540,
KW ECO:0000313|EMBL:BAJ08423.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917}.
FT DOMAIN 1..201
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:BAJ08423.1"
FT NON_TER 385
FT /evidence="ECO:0000313|EMBL:BAJ08423.1"
SQ SEQUENCE 385 AA; 41548 MW; 5E7372AB1F5B934C CRC64;
IGHVAHGKST VVKAISGVHT VRFKNELERN ITIKLGYANA KIYKLDDASC PRPECYRSCG
SSTPDEFPTD IPGTKGNFKL VRHVSFVDCP GHDILMATML NGAAVMDAAL LLIAGNESCP
QPQTSEHLAA IEIMKLKHIL ILQNKIDLVK ESQAKEQYEQ ILAFVQGTVA EGAPIIPISA
QLKYNIEVVC EYIVKKIPVP LRDFTSEPRL IVIRSFDVNK PGCEVDDLKG GVAGGSILKG
ILKVGQEIEV RPGIVSKGSE GKLMCKPIFS KIVSLFAEHN DLQYAAPGGL IGVGTKIDPT
LCRADRMVGQ VLGAVGALPE IFTELEISYF LLRRLLGVRT EGDKKAAKVQ KLSKNEVLMV
NIGSLSTGGR VSAVKADLGK IVLTN
//
