ID D6W6H4_TRICA Unreviewed; 1796 AA.
AC D6W6H4;
DT 10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT 10-AUG-2010, sequence version 1.
DT 27-MAR-2024, entry version 73.
DE RecName: Full=Activin-binding protein {ECO:0000256|ARBA:ARBA00042260};
GN Name=AUGUSTUS-3.0.2_04709 {ECO:0000313|EMBL:EFA11111.1};
GN ORFNames=TcasGA2_TC004709 {ECO:0000313|EMBL:EFA11111.1};
OS Tribolium castaneum (Red flour beetle).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Coleoptera; Polyphaga; Cucujiformia;
OC Tenebrionidae; Tenebrionidae incertae sedis; Tribolium.
OX NCBI_TaxID=7070 {ECO:0000313|EMBL:EFA11111.1, ECO:0000313|Proteomes:UP000007266};
RN [1] {ECO:0000313|EMBL:EFA11111.1, ECO:0000313|Proteomes:UP000007266}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Georgia GA2 {ECO:0000313|EMBL:EFA11111.1,
RC ECO:0000313|Proteomes:UP000007266};
RX PubMed=18362917; DOI=10.1038/nature06784;
RG Tribolium Genome Sequencing Consortium;
RA Richards S., Gibbs R.A., Weinstock G.M., Brown S.J., Denell R.,
RA Beeman R.W., Gibbs R., Beeman R.W., Brown S.J., Bucher G., Friedrich M.,
RA Grimmelikhuijzen C.J., Klingler M., Lorenzen M., Richards S., Roth S.,
RA Schroder R., Tautz D., Zdobnov E.M., Muzny D., Gibbs R.A., Weinstock G.M.,
RA Attaway T., Bell S., Buhay C.J., Chandrabose M.N., Chavez D.,
RA Clerk-Blankenburg K.P., Cree A., Dao M., Davis C., Chacko J., Dinh H.,
RA Dugan-Rocha S., Fowler G., Garner T.T., Garnes J., Gnirke A., Hawes A.,
RA Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N., Joshi V.,
RA Khan Z.M., Jackson L., Kovar C., Kowis A., Lee S., Lewis L.R., Margolis J.,
RA Morgan M., Nazareth L.V., Nguyen N., Okwuonu G., Parker D., Richards S.,
RA Ruiz S.J., Santibanez J., Savard J., Scherer S.E., Schneider B.,
RA Sodergren E., Tautz D., Vattahil S., Villasana D., White C.S., Wright R.,
RA Park Y., Beeman R.W., Lord J., Oppert B., Lorenzen M., Brown S., Wang L.,
RA Savard J., Tautz D., Richards S., Weinstock G., Gibbs R.A., Liu Y.,
RA Worley K., Weinstock G., Elsik C.G., Reese J.T., Elhaik E., Landan G.,
RA Graur D., Arensburger P., Atkinson P., Beeman R.W., Beidler J., Brown S.J.,
RA Demuth J.P., Drury D.W., Du Y.Z., Fujiwara H., Lorenzen M., Maselli V.,
RA Osanai M., Park Y., Robertson H.M., Tu Z., Wang J.J., Wang S., Richards S.,
RA Song H., Zhang L., Sodergren E., Werner D., Stanke M., Morgenstern B.,
RA Solovyev V., Kosarev P., Brown G., Chen H.C., Ermolaeva O., Hlavina W.,
RA Kapustin Y., Kiryutin B., Kitts P., Maglott D., Pruitt K., Sapojnikov V.,
RA Souvorov A., Mackey A.J., Waterhouse R.M., Wyder S., Zdobnov E.M.,
RA Zdobnov E.M., Wyder S., Kriventseva E.V., Kadowaki T., Bork P., Aranda M.,
RA Bao R., Beermann A., Berns N., Bolognesi R., Bonneton F., Bopp D.,
RA Brown S.J., Bucher G., Butts T., Chaumot A., Denell R.E., Ferrier D.E.,
RA Friedrich M., Gordon C.M., Jindra M., Klingler M., Lan Q., Lattorff H.M.,
RA Laudet V., von Levetsow C., Liu Z., Lutz R., Lynch J.A., da Fonseca R.N.,
RA Posnien N., Reuter R., Roth S., Savard J., Schinko J.B., Schmitt C.,
RA Schoppmeier M., Schroder R., Shippy T.D., Simonnet F., Marques-Souza H.,
RA Tautz D., Tomoyasu Y., Trauner J., Van der Zee M., Vervoort M.,
RA Wittkopp N., Wimmer E.A., Yang X., Jones A.K., Sattelle D.B., Ebert P.R.,
RA Nelson D., Scott J.G., Beeman R.W., Muthukrishnan S., Kramer K.J.,
RA Arakane Y., Beeman R.W., Zhu Q., Hogenkamp D., Dixit R., Oppert B.,
RA Jiang H., Zou Z., Marshall J., Elpidina E., Vinokurov K., Oppert C.,
RA Zou Z., Evans J., Lu Z., Zhao P., Sumathipala N., Altincicek B.,
RA Vilcinskas A., Williams M., Hultmark D., Hetru C., Jiang H.,
RA Grimmelikhuijzen C.J., Hauser F., Cazzamali G., Williamson M., Park Y.,
RA Li B., Tanaka Y., Predel R., Neupert S., Schachtner J., Verleyen P.,
RA Raible F., Bork P., Friedrich M., Walden K.K., Robertson H.M., Angeli S.,
RA Foret S., Bucher G., Schuetz S., Maleszka R., Wimmer E.A., Beeman R.W.,
RA Lorenzen M., Tomoyasu Y., Miller S.C., Grossmann D., Bucher G.;
RT "The genome of the model beetle and pest Tribolium castaneum.";
RL Nature 452:949-955(2008).
RN [2] {ECO:0000313|EMBL:EFA11111.1, ECO:0000313|Proteomes:UP000007266}
RP GENOME REANNOTATION.
RC STRAIN=Georgia GA2 {ECO:0000313|EMBL:EFA11111.1,
RC ECO:0000313|Proteomes:UP000007266};
RX PubMed=19820115; DOI=10.1093/nar/gkp807;
RA Kim H.S., Murphy T., Xia J., Caragea D., Park Y., Beeman R.W.,
RA Lorenzen M.D., Butcher S., Manak J.R., Brown S.J.;
RT "BeetleBase in 2010: revisions to provide comprehensive genomic information
RT for Tribolium castaneum.";
RL Nucleic Acids Res. 38:D437-D442(2010).
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; KQ971307; EFA11111.1; -; Genomic_DNA.
DR STRING; 7070.D6W6H4; -.
DR EnsemblMetazoa; TC004709_001; TC004709_001; TC004709.
DR eggNOG; KOG3509; Eukaryota.
DR HOGENOM; CLU_001582_2_0_1; -.
DR InParanoid; D6W6H4; -.
DR OMA; AMEISPF; -.
DR PhylomeDB; D6W6H4; -.
DR Proteomes; UP000007266; Linkage group 1.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IEA:UniProt.
DR GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0016043; P:cellular component organization; IEA:UniProt.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR CDD; cd00054; EGF_CA; 3.
DR CDD; cd00055; EGF_Lam; 2.
DR CDD; cd00104; KAZAL_FS; 7.
DR CDD; cd00110; LamG; 3.
DR Gene3D; 2.60.120.200; -; 3.
DR Gene3D; 3.30.60.30; -; 9.
DR Gene3D; 2.10.25.10; Laminin; 6.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR003884; FacI_MAC.
DR InterPro; IPR003645; Fol_N.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR002350; Kazal_dom.
DR InterPro; IPR036058; Kazal_dom_sf.
DR InterPro; IPR001791; Laminin_G.
DR InterPro; IPR002049; LE_dom.
DR PANTHER; PTHR10913:SF45; AGRIN; 1.
DR PANTHER; PTHR10913; FOLLISTATIN-RELATED; 1.
DR Pfam; PF00008; EGF; 2.
DR Pfam; PF07648; Kazal_2; 9.
DR Pfam; PF00053; Laminin_EGF; 2.
DR Pfam; PF00054; Laminin_G_1; 2.
DR Pfam; PF02210; Laminin_G_2; 1.
DR PRINTS; PR00011; EGFLAMININ.
DR SMART; SM00181; EGF; 7.
DR SMART; SM00179; EGF_CA; 3.
DR SMART; SM00180; EGF_Lam; 2.
DR SMART; SM00057; FIMAC; 5.
DR SMART; SM00274; FOLN; 8.
DR SMART; SM00280; KAZAL; 9.
DR SMART; SM00282; LamG; 3.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 3.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF100895; Kazal-type serine protease inhibitors; 9.
DR PROSITE; PS00022; EGF_1; 4.
DR PROSITE; PS50026; EGF_3; 4.
DR PROSITE; PS01248; EGF_LAM_1; 1.
DR PROSITE; PS50027; EGF_LAM_2; 1.
DR PROSITE; PS51465; KAZAL_2; 8.
DR PROSITE; PS50025; LAM_G_DOMAIN; 3.
PE 4: Predicted;
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Laminin EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00460};
KW Reference proteome {ECO:0000313|Proteomes:UP000007266};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 1..50
FT /note="Kazal-like"
FT /evidence="ECO:0000259|PROSITE:PS51465"
FT DOMAIN 77..129
FT /note="Kazal-like"
FT /evidence="ECO:0000259|PROSITE:PS51465"
FT DOMAIN 145..199
FT /note="Kazal-like"
FT /evidence="ECO:0000259|PROSITE:PS51465"
FT DOMAIN 219..271
FT /note="Kazal-like"
FT /evidence="ECO:0000259|PROSITE:PS51465"
FT DOMAIN 272..344
FT /note="Kazal-like"
FT /evidence="ECO:0000259|PROSITE:PS51465"
FT DOMAIN 367..417
FT /note="Kazal-like"
FT /evidence="ECO:0000259|PROSITE:PS51465"
FT DOMAIN 435..486
FT /note="Kazal-like"
FT /evidence="ECO:0000259|PROSITE:PS51465"
FT DOMAIN 695..747
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 820..876
FT /note="Kazal-like"
FT /evidence="ECO:0000259|PROSITE:PS51465"
FT DOMAIN 1029..1066
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1074..1252
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 1253..1290
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1292..1329
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1337..1514
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 1522..1560
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1615..1791
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DISULFID 695..707
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 697..714
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 716..725
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1056..1065
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1280..1289
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1319..1328
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1550..1559
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 1796 AA; 197469 MW; CB11C46B77DE1E96 CRC64;
MCQCPTHCKQ KVDLVCGTDG KTYANRCQLR VASCKARLNT RVKHDGECEQ NDPCRDKQCG
FGARCVVSPD GRNASCVCPD KCPSYGDHTT SRPVCGSDGI DYRNQCELQK AACTSNTNIT
IKFLGKCDPC AGVECAEPEV CQLDEHRNPV CRCGDSCPLE FTPVCGSDGK TYSNECTLRQ
EACRARKNLH IIYRGKCSSG INPCMSVRCT LGEECAINKF GIARCQCPPS CEPIMRPVCS
KDGRTFPSEC ELKRTACLTR TTIEISYSGV CGEKGPCSEY QCQNGATCVE RFGVAHCECP
VCPAEFEPVC GSDGISYGNE CKLRLEACKH PRNITVLYDG PCNGCETKKC DFYSVCERDS
ATEGRCVCPK SCTDPELNDG TVCGTDGVTY ANECELRMTS CKMKQFILVA YKGNCDLCQG
VECKYGGRCE AGKCVCPTNC EGSGDEPVCA SNMMTFPNEC ELQKAMCLQP TNSPPLSVVF
YGDCREKFPV AGSLSTTLSP FTAQTNNIGP GTDLDTVGPE NTIPDLSTVE KEACRDIHCD
FEATCELGPD NFPRCTCQFD CASAALVSAS KPVCASDLQI YPSLCAMKME ACQRQEELRL
RPLDLCQGME VKPCNGEKPL TDPLTGKELD CGSGPKRQDC PSGSYCHQTT RFSRCCPKDQ
GLLEQKSCED SWHGCCPDGK TAAQGPNHAG CPSLCGCNKL GSYSDTCDPE TQQCRCRPGV
GGAKCDRCEP GYWGLPKISS GYHGCIPCGC STFGSVRDDC EQMTGRCVCN PGVQGQKCTV
CTSHDKVLGP NGCVPADLTT SPPTTCKELT CYFGATCVER GGFAICECHT ECPQENDAQV
VCGSDGQTYA SACELRQVAC RTQKDIVVQA FGTCKDDMFP STDWPIRRYT PLQFTQPDDS
NSPLSKSTRH LLVPDPRYYY GSSGSIMRPV QGVSYPAETD NKAAFEINVS ATGPNAIYNT
RGGNYAPAYR PTPATVRVIT ALLGDLCSDN SDCMIMYSHC VSGACTCLPN HSESSDRQEC
IADPNPTDEY RACSSSPCHH GSTCVDLPAA TFTCVCETNF TGSLCETEVI HKQYNTPAFH
GRSYVKLKPL KAYHKLSIEV EFKTHSHDGL LLYNQQKPDG LGDFVSLAIV NGFVEFKYNL
GNGHVLIRSV DKIQLGVFHR VVIKRYHRDG ILKLDEGEDV AGQAKGTLKA LDLLEDTYVG
FLPSNYTRVY ENIGTAKGFR GCIRKLKIGR RPIELHVNRD DWVLGAEAVS ECGDSPCSAA
PCANDAKCAL ITPETYRCEC GPHYRGEFCE KPIEPCRSNP CKFGSTCTPL SPDAYICECP
PGRTGTRCEM EDKYMGIVNP EFSGSSYIRL PRLEGVRKTF SIEVYFMPKA ANGLILYNGQ
LKNGRGDFIS LNLARGHLQF RFNLGSGIAN LTTKETVNIG KWHWARIFRD GREGILQLDN
SSIVRGYSGT PLTELNLELP FYIGSLSEWD EVHRLSGASK GYKGVIQRIL LNGKPLPISA
KLPDCSFDSN RNGCAFNVGS YDGLPCPISK NPCLNNGLCV PELDQFICKC PSNTKGKYCE
ISQEETPAIK FNGATFLQFR NRGYRSHNLT ISDEYPDNEE DDIDNIEEDV VDNNTYDAYD
DEEYYFDFYD TARRKPERGN RYEIKLRTFA SDALLLWRSK SRSIREDYFS IAVVNGYPEI
SYNLGKQDVF WAIRSKTKID DGKWHTIQVR RRKRVGFISI DGEPPIKGLS KYGAISLRTN
SKLWIGGTAN LPQGLPSAYY KGFEGCIQHI LVNAKPLDMV SNNELNKVNF CHDNEI
//
