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Database: UniProt
Entry: D6WF72_TRICA
LinkDB: D6WF72_TRICA
Original site: D6WF72_TRICA 
ID   D6WF72_TRICA            Unreviewed;      5011 AA.
AC   D6WF72;
DT   10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT   11-MAY-2016, sequence version 2.
DT   05-JUL-2017, entry version 49.
DE   SubName: Full=Ryanodine receptor 44F-like Protein {ECO:0000313|EMBL:EEZ99829.2};
GN   ORFNames=TcasGA2_TC002610 {ECO:0000313|EMBL:EEZ99829.2};
OS   Tribolium castaneum (Red flour beetle).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Coleoptera; Polyphaga;
OC   Cucujiformia; Tenebrionidae; Tenebrionidae incertae sedis; Tribolium.
OX   NCBI_TaxID=7070 {ECO:0000313|EMBL:EEZ99829.2, ECO:0000313|Proteomes:UP000007266};
RN   [1] {ECO:0000313|EMBL:EEZ99829.2, ECO:0000313|Proteomes:UP000007266}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Georgia GA2 {ECO:0000313|EMBL:EEZ99829.2,
RC   ECO:0000313|Proteomes:UP000007266};
RX   PubMed=18362917; DOI=10.1038/nature06784;
RG   Tribolium Genome Sequencing Consortium;
RA   Richards S., Gibbs R.A., Weinstock G.M., Brown S.J., Denell R.,
RA   Beeman R.W., Gibbs R., Beeman R.W., Brown S.J., Bucher G.,
RA   Friedrich M., Grimmelikhuijzen C.J., Klingler M., Lorenzen M.,
RA   Richards S., Roth S., Schroder R., Tautz D., Zdobnov E.M., Muzny D.,
RA   Gibbs R.A., Weinstock G.M., Attaway T., Bell S., Buhay C.J.,
RA   Chandrabose M.N., Chavez D., Clerk-Blankenburg K.P., Cree A., Dao M.,
RA   Davis C., Chacko J., Dinh H., Dugan-Rocha S., Fowler G., Garner T.T.,
RA   Garnes J., Gnirke A., Hawes A., Hernandez J., Hines S., Holder M.,
RA   Hume J., Jhangiani S.N., Joshi V., Khan Z.M., Jackson L., Kovar C.,
RA   Kowis A., Lee S., Lewis L.R., Margolis J., Morgan M., Nazareth L.V.,
RA   Nguyen N., Okwuonu G., Parker D., Richards S., Ruiz S.J.,
RA   Santibanez J., Savard J., Scherer S.E., Schneider B., Sodergren E.,
RA   Tautz D., Vattahil S., Villasana D., White C.S., Wright R., Park Y.,
RA   Beeman R.W., Lord J., Oppert B., Lorenzen M., Brown S., Wang L.,
RA   Savard J., Tautz D., Richards S., Weinstock G., Gibbs R.A., Liu Y.,
RA   Worley K., Weinstock G., Elsik C.G., Reese J.T., Elhaik E., Landan G.,
RA   Graur D., Arensburger P., Atkinson P., Beeman R.W., Beidler J.,
RA   Brown S.J., Demuth J.P., Drury D.W., Du Y.Z., Fujiwara H.,
RA   Lorenzen M., Maselli V., Osanai M., Park Y., Robertson H.M., Tu Z.,
RA   Wang J.J., Wang S., Richards S., Song H., Zhang L., Sodergren E.,
RA   Werner D., Stanke M., Morgenstern B., Solovyev V., Kosarev P.,
RA   Brown G., Chen H.C., Ermolaeva O., Hlavina W., Kapustin Y.,
RA   Kiryutin B., Kitts P., Maglott D., Pruitt K., Sapojnikov V.,
RA   Souvorov A., Mackey A.J., Waterhouse R.M., Wyder S., Zdobnov E.M.,
RA   Zdobnov E.M., Wyder S., Kriventseva E.V., Kadowaki T., Bork P.,
RA   Aranda M., Bao R., Beermann A., Berns N., Bolognesi R., Bonneton F.,
RA   Bopp D., Brown S.J., Bucher G., Butts T., Chaumot A., Denell R.E.,
RA   Ferrier D.E., Friedrich M., Gordon C.M., Jindra M., Klingler M.,
RA   Lan Q., Lattorff H.M., Laudet V., von Levetsow C., Liu Z., Lutz R.,
RA   Lynch J.A., da Fonseca R.N., Posnien N., Reuter R., Roth S.,
RA   Savard J., Schinko J.B., Schmitt C., Schoppmeier M., Schroder R.,
RA   Shippy T.D., Simonnet F., Marques-Souza H., Tautz D., Tomoyasu Y.,
RA   Trauner J., Van der Zee M., Vervoort M., Wittkopp N., Wimmer E.A.,
RA   Yang X., Jones A.K., Sattelle D.B., Ebert P.R., Nelson D., Scott J.G.,
RA   Beeman R.W., Muthukrishnan S., Kramer K.J., Arakane Y., Beeman R.W.,
RA   Zhu Q., Hogenkamp D., Dixit R., Oppert B., Jiang H., Zou Z.,
RA   Marshall J., Elpidina E., Vinokurov K., Oppert C., Zou Z., Evans J.,
RA   Lu Z., Zhao P., Sumathipala N., Altincicek B., Vilcinskas A.,
RA   Williams M., Hultmark D., Hetru C., Jiang H., Grimmelikhuijzen C.J.,
RA   Hauser F., Cazzamali G., Williamson M., Park Y., Li B., Tanaka Y.,
RA   Predel R., Neupert S., Schachtner J., Verleyen P., Raible F., Bork P.,
RA   Friedrich M., Walden K.K., Robertson H.M., Angeli S., Foret S.,
RA   Bucher G., Schuetz S., Maleszka R., Wimmer E.A., Beeman R.W.,
RA   Lorenzen M., Tomoyasu Y., Miller S.C., Grossmann D., Bucher G.;
RT   "The genome of the model beetle and pest Tribolium castaneum.";
RL   Nature 452:949-955(2008).
RN   [2] {ECO:0000313|EMBL:EEZ99829.2, ECO:0000313|Proteomes:UP000007266}
RP   GENOME REANNOTATION.
RC   STRAIN=Georgia GA2 {ECO:0000313|EMBL:EEZ99829.2,
RC   ECO:0000313|Proteomes:UP000007266};
RX   PubMed=19820115; DOI=10.1093/nar/gkp807;
RA   Kim H.S., Murphy T., Xia J., Caragea D., Park Y., Beeman R.W.,
RA   Lorenzen M.D., Butcher S., Manak J.R., Brown S.J.;
RT   "BeetleBase in 2010: revisions to provide comprehensive genomic
RT   information for Tribolium castaneum.";
RL   Nucleic Acids Res. 38:D437-D442(2010).
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DR   EMBL; KQ971327; EEZ99829.2; -; Genomic_DNA.
DR   EnsemblMetazoa; TC002610_001; TC002610_001; TC002610.
DR   eggNOG; KOG2243; Eukaryota.
DR   eggNOG; ENOG410YCNW; LUCA.
DR   InParanoid; D6WF72; -.
DR   Proteomes; UP000007266; Linkage group 3.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 3.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS00018; EF_HAND_1; 1.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50919; MIR; 4.
PE   4: Predicted;
KW   Calcium {ECO:0000256|PROSITE-ProRule:PRU00448};
KW   Complete proteome {ECO:0000313|Proteomes:UP000007266};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000313|EMBL:EEZ99829.2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007266};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4346   4373       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4545   4563       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4618   4640       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4764   4785       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4808   4830       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4888   4907       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       99    153       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      160    205       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      273    331       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      339    397       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      576    801       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1030   1213       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1466   1688       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     4102   4128       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   CA_BIND    4106   4117       {ECO:0000256|PROSITE-ProRule:PRU00448}.
SQ   SEQUENCE   5011 AA;  567660 MW;  F5B066543746CAA8 CRC64;
     MAEAEGGSEQ DDVSFLRTED MVCLSCTATG ERVCLAAEGF GNRHCFLENI ADKNIPPDLS
     QCVFVIEQAL SVRALQELVT AAGNETGQEN LGKGTGSGHR TLLYGNAILL RHQNSDMYLA
     CLSTSSSNDK LAFDVGLQEH SQGEACWWTV HPASKQRSEG EKVRVGDDLI LVSVATERYL
     HTTKENEISI VNASFHVTHW SVQPYGTGIS RMKYVGYVFG GDVLRFFHGG DECLTIPSTW
     SIDANIVIYE GGSVMSQARS LWRLELARTK WAGGFINWSH PMRIRHITTG RYLAVNENNE
     LYLVSREEAN TATTAFCLRQ EKDDQKVVLE DKDLEVIGSP IIKYGDSTVI VQHSETGLWL
     SYKSYETKKK GVGKVEEKQA ILHEEGKMDD GLDFSRSQEE ESRTARVIRK CSSLFTQFIN
     GLETLQMNRR HSVFFLAVNL NEMVMCLEDL INYFAQPEDD MEHEEKQNRF RALRNRQDLF
     QEEGILNLIL EAIDKINVIT SQGFLAGLAG DQNWEMISGY LYQLLAAIIK GNHTNCAQFA
     NSNRLNWLFS RLGSQASSEG TGMLDVLHCV LIDSPEALNM MRDEHIKVII SLLEKHGRDP
     KVLDVLCSLC VGNGVAVRSS QNNICDYLLP GKNLLLQTQL VDHVASVRPN IFVGRVDGSA
     IYQKWYFEVT VDHIEQTTHM MPHLRIGWAN SKGYVPYPGG GEKWGGNGVG DDLYSYGFDG
     VYLWSGGRST QVVTTYTTPF IKKNDVVGCA LDLTVPIITF TFNGVPIKGS FRNFNLDGMF
     FPVISCSSKL SCRFLLGGDH GRLKYIPPEE FSPLVESLLP QQILNLEPCF YFGNMNKNVI
     AGPLTVEDDT AFVPNPVDTS MVSLASYVES IRDKLAENIH EMWAMNKIEA GWQWGEYRDD
     LRHIHPCLVP FDKLPPAEKK YDSQLAVQTL KTIIALGYHI TMDKPPSRIK TVRLPNEPFM
     QSNGYKPAPL DLSAITLTPK LEELVDQLAE NTHNLWAKER IQQGWTYGLN EDPDMFRSPH
     LVPYIKVDDA IKKANRDTAS ETVRTLLVYG YNLDPPTGEQ HEALLAEASR SRQAIFRTYR
     AEKNYAVSSG KWYFEFEILT AGPMRVGWAK ADCAPGCMLG SDENTWAFDG YNEEKVYSNS
     AESFGKQWQV GDVVGVFLDL IDHTISFSLN GELLMDALGG ETTFADVQGD NFVPAFTLGV
     GQKARLCFGQ DVTQLKYFTM CGLQEGYEPF CVNMKRPVTY WYTKDQPIFE NTDDMPDTKI
     DVTRILAGSD SPPCLKISHN TFETMEKANW EFLRLSLPVI CHSTFISEDE KMRRWQEIKI
     RQHRLKAEAE SNISPAHIEQ MMMKSGFSMS DIKGLHRNYS EDAVESDEVM KHHGKSTKSM
     PARPPRKGSL SRNVNGFEDN MLGANTGRGV NRSTSELNLN RYHDMAPANQ EKPDEKKKRG
     RSPFRFFSRK KAGNSPGGES VKADKSKTPD RERERMGTIK VPTRQAGVSP SRLTRSPTIK
     QSQSDLMQVP AAASGQQKQL SVPHTSDVEA VGDELFDGEC LKLINEYFYG VRIFPGQDPT
     HVYVGWVTTQ YHRHTKDFNQ NQVRKSSIVI LDDYDRVVDC VDRQSCYMVR ADELYNQVTQ
     DASGKGASQG MFIGCFLDAA TGVITFTCEG KPTSHVFRME PETKLFPAIF VEATSKEILQ
     IELGRTPTSL PLSAAVLQNS AKHVIPQFPP RLKVQCLKPH QWARVPNQSL QVHALKLSDI
     RGWSMLCEDA ISMLALHIPE EDRCIDVLEL IEMDKLLSFH AHTLTLYAAL CYQSNYKAAH
     VLCKHVNQRQ LLYAIKAEYM SGPLRQGFYD LLIAVHIESA ATTMEVCQNE YVIPLSQELK
     EMYEDPEMRH SLRALMMESV QPQMKMSDIT DTVENIKNLY SPYFPLDIVR DYVMTALAEA
     VETNQVHNRD PIGGSNENLF LPLLKLVDRL LLVGMLRDED IAKLLIMICP ETWDPSFVKD
     GKDEHRKGLL SMKMAEGAKL QMCYLLQHLC DIQLRHRVES IIAFSHDFVG DLQSDQLRRY
     IEIKQSDLPS AVAAKKTREF RCPPREQMNA ILSFKNLEEE DKENCPLGEE LCEKLNDFHG
     LLMSHVSLQA LQAPEEEEGN DVQKPGPFKR LYNFINAVKE LEEEPKEEPE PEKKTPEEIF
     RKVLISTIVQ WAEEAQIETP KLVQEMFSLL VRQYDSVGEL IRALQKTYVI NAKTKQDVAE
     MWVGLSKIRA LLPVQMSQEE EELMRERLWK LVNNHTFFQH PDLIRVLRIH ENVMAVMINT
     LGRRSQAQSD AQAQAQAAEG DTTVKEKDTS HEMVVACCRF LCYFCRTGRQ NQKAMFEHFD
     FLLENSNILL ARPSLRGSTP LDVAYSSLME NTELALALRE HYLEKIAIYL SRCGLQSNSE
     LVEKGYPDLG WDPVEGERYL DFLRFCVWVN GESVEENANL VIRLLIRRPE CLGPALRGEG
     EGLLRAIVDA NKMSERISDR RKMMDEAEGT VNVAPFTHPL PESDDDEDYI DTGAAILNFY
     CTLVDLLGRC APDATVIELG KNESLRARAI LRSLVPLEDL QGVLSLRFTL QNPAAGEERP
     KSDMPSELRN ETQELSQIVG GSVSADLRCA TMLDRNDGSE SDMALSMNRY IGNSILPLLI
     QHSKFYSEAE NYASLLDATL HTVYRLSKNR MLTKGQREAV SDFLVALTSA LQPSMLLKLL
     RKLTVDVSNL SEYTTVALRL LTLHYDRCAK YYGSSTGQGL YGAASDEEKR LTMMLFSNIF
     DSLSKMDYDP ELFGKALPCL SAIGCALPPD YSLSKNYDDE WYANKSAKTG PDGPYNPQPI
     NTSSVALNND LNSIVQQFSE HYHDAWASRK LENGWQYGET WSDSNKTHPR LKPYSMLNDY
     EKERYKEPVR ESLKALLAIG WSVEHSEVDH PSTNRNSVHH QSGEGSSPFN YNPHPVDMTN
     LTLSREMQNM AERLAENAHD IWAKKKKEEL NTCGGGIHPQ LVPYDLLTDK EKRKDRERSQ
     EFLKYLQYQG YKLHKPIRGG QGETEQTTAG ASIELRFAYS LLEKLIQYAD RATINMKLLK
     PSSTFSRRPS YKTSSRDIKF FSKVVLPLME KYFSTHRNYF IAIATATNNV GAASLKEKEM
     VASLFCKLAS LLRSKLTAFG ADVRITVRCL QVLVKGIDAK SLVKNCPEFI RTSMLTFFNN
     TADDLGHTII NLQEGKYSHL RGTHLKTSTS LFYVNTVIIP ILTAMFDHLA NCEYGSDLLL
     DEIQVASYKI LQALYTLGTD TTLTHDRKYL KTEIEKYKPA LGSCLGAFSS TFPVAFLEPH
     LNKNNQFSLL NRIADHSLEA QAEHMNHLLK NVLKLIKKNI GNETAPWMTR IAAYTQQIII
     NSSEELLRDP FLPLAERVKK RTETMFHKEE SLRGFIKSSS DDTSQIETQI QEDWHLLVRD
     IYAFYPLLIK YVDLQRNHWL RHNIAEAEDL YNHVADIFNI WSKSQYFLRE EQNFISANEI
     DNMVLIMPTA TRRPVVTDGT QQTGGKKKKK HRDKKRDKDK EIQASLMVAC LKRLLPVGLN
     LFAGREQELV QHCKDRFLKK APEYDIIEFA KTQLTLPDKI DPADEMSWQH YLYSQLGSKK
     SAAVGMVDNN GKNLLEETVD RIVAMSKVLY GLHMIDHPQQ QQKGVYHSVV STQRKRAVLS
     CFRQASLHSL PRHRAINIFI RSYYELWLQD ENVGQEVMIE DLTQSFEDSE LKKKDGEEEE
     SKPDPLTQLV TTFCRGAMTE RSGALQEDPL YMSYAEIIAK SCGEEEEEGE EEESGEGEEG
     GASIHEQEME KQKLLFNQAR LAKRGVAEMV LLHISACKGV PSEMVMKTLE LGISILRGGN
     FDIQMGMLNH LKEKKDVGFF TSIAGLMNSC SVLDLDAFER NTKAEGLGVG SEGAAGEKNM
     HDAEFTCALF RFIQLTCEGH NLEWQNYLRT QAGNTTTVNV VICTVDYLLR LQESIMDFYW
     HYSSKDLIDP AGKANFFKAI GVASQVFNTL TEVIQGPCTL NQQALAHSRL WDAVGGFLFL
     FSHMQDKLSK HSSQVDLLKE LLNLQKDMIT MMLSMLEGNV VNGTIGKQMV DTLVESASNV
     ELILKYFDMF LKLKDLTSSP SFQEIDINND GWVSPKDFKE KMEQQKSYTS EEIDFLLACC
     EVNHDGKVDY IGFIDRFHEP AKEIGFNLAV LLTNLSEHMP NEPRLARFLE TAGSVLNYFE
     PFLGRIEILG GSKRIERVYF EIKESNIEQW EKPQIKESKR AFFYSIVTEG GDKEKLEAFI
     NFCEDAIFEM QHASGLMAVE ESGGGGPTRA ASYSYMNVDD EDRGKDPIRR GYQSIKEGIA
     YGLSSLSPSN IKHKFAEMQQ MTIPELFIGF FRMIIYAFYY SGFGVAIIFK YIFGVLLSLM
     RGPIEEPAVL EIKEEEEKVG LSRVLPALPS SEEQNTQMQA FGLDITKEDN GQYKMAAHES
     PTTSQPSSAE GEGETTPEED GEHPETETME APLSLSDLLG GEQAKRAAQE KVEAQAAQQA
     VMQAIESESK QPVVTEPSAV SQINFGAYSH RAVSFLARNF YNLKYVALVL AFCINFMLLF
     YRVSTLGDDA EGSGSKGIPD ILEGSAEGSG AGSGESGEDD DPPELVHVDE DFYYMAHVMR
     LAAILHSVVS LAMLIAYYNL KVPLAIFKRE KEIARRLEFE GLYIAEQPED DDLKSHWDKL
     VISAKSFPVN YWDKFIKKKV RQKYSETYDF DSISNLLGME KTSFQQQESD EGRSFIYFII
     NIDWRYQIWK SGVTITDNSF LYSLWYFIFS ILGNFNNFFF AAHLLDVAVG FKTLRTILQS
     VTHNGKQLVL TVMLLTIVVY IYTVIAFNFF RKFYVQEEDE EVDKKCHDML TCFVFHLYKG
     VRAGGGIGDE IEPPDGDDYE VYRIMFDITF FFFVIVILLA IIQGLIIDAF GELRDQLESV
     KEDMESNCFI CGMGKEYFDK VPHGFDTHVQ QEHNLANYMF FLMHLINKPD TEYTGQETYV
     WNMYQQRCWD FFPVGDCFRK QYEEELGGGG G
//
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