ID D6WKS5_TRICA Unreviewed; 1499 AA.
AC D6WKS5;
DT 10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT 10-AUG-2010, sequence version 1.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=Protein eyes shut homolog-like Protein {ECO:0000313|EMBL:EFA03035.1};
GN Name=AUGUSTUS-3.0.2_10461 {ECO:0000313|EMBL:EFA03035.1};
GN ORFNames=TcasGA2_TC010461 {ECO:0000313|EMBL:EFA03035.1};
OS Tribolium castaneum (Red flour beetle).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Coleoptera; Polyphaga; Cucujiformia;
OC Tenebrionidae; Tenebrionidae incertae sedis; Tribolium.
OX NCBI_TaxID=7070 {ECO:0000313|EMBL:EFA03035.1, ECO:0000313|Proteomes:UP000007266};
RN [1] {ECO:0000313|EMBL:EFA03035.1, ECO:0000313|Proteomes:UP000007266}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Georgia GA2 {ECO:0000313|EMBL:EFA03035.1,
RC ECO:0000313|Proteomes:UP000007266};
RX PubMed=18362917; DOI=10.1038/nature06784;
RG Tribolium Genome Sequencing Consortium;
RA Richards S., Gibbs R.A., Weinstock G.M., Brown S.J., Denell R.,
RA Beeman R.W., Gibbs R., Beeman R.W., Brown S.J., Bucher G., Friedrich M.,
RA Grimmelikhuijzen C.J., Klingler M., Lorenzen M., Richards S., Roth S.,
RA Schroder R., Tautz D., Zdobnov E.M., Muzny D., Gibbs R.A., Weinstock G.M.,
RA Attaway T., Bell S., Buhay C.J., Chandrabose M.N., Chavez D.,
RA Clerk-Blankenburg K.P., Cree A., Dao M., Davis C., Chacko J., Dinh H.,
RA Dugan-Rocha S., Fowler G., Garner T.T., Garnes J., Gnirke A., Hawes A.,
RA Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N., Joshi V.,
RA Khan Z.M., Jackson L., Kovar C., Kowis A., Lee S., Lewis L.R., Margolis J.,
RA Morgan M., Nazareth L.V., Nguyen N., Okwuonu G., Parker D., Richards S.,
RA Ruiz S.J., Santibanez J., Savard J., Scherer S.E., Schneider B.,
RA Sodergren E., Tautz D., Vattahil S., Villasana D., White C.S., Wright R.,
RA Park Y., Beeman R.W., Lord J., Oppert B., Lorenzen M., Brown S., Wang L.,
RA Savard J., Tautz D., Richards S., Weinstock G., Gibbs R.A., Liu Y.,
RA Worley K., Weinstock G., Elsik C.G., Reese J.T., Elhaik E., Landan G.,
RA Graur D., Arensburger P., Atkinson P., Beeman R.W., Beidler J., Brown S.J.,
RA Demuth J.P., Drury D.W., Du Y.Z., Fujiwara H., Lorenzen M., Maselli V.,
RA Osanai M., Park Y., Robertson H.M., Tu Z., Wang J.J., Wang S., Richards S.,
RA Song H., Zhang L., Sodergren E., Werner D., Stanke M., Morgenstern B.,
RA Solovyev V., Kosarev P., Brown G., Chen H.C., Ermolaeva O., Hlavina W.,
RA Kapustin Y., Kiryutin B., Kitts P., Maglott D., Pruitt K., Sapojnikov V.,
RA Souvorov A., Mackey A.J., Waterhouse R.M., Wyder S., Zdobnov E.M.,
RA Zdobnov E.M., Wyder S., Kriventseva E.V., Kadowaki T., Bork P., Aranda M.,
RA Bao R., Beermann A., Berns N., Bolognesi R., Bonneton F., Bopp D.,
RA Brown S.J., Bucher G., Butts T., Chaumot A., Denell R.E., Ferrier D.E.,
RA Friedrich M., Gordon C.M., Jindra M., Klingler M., Lan Q., Lattorff H.M.,
RA Laudet V., von Levetsow C., Liu Z., Lutz R., Lynch J.A., da Fonseca R.N.,
RA Posnien N., Reuter R., Roth S., Savard J., Schinko J.B., Schmitt C.,
RA Schoppmeier M., Schroder R., Shippy T.D., Simonnet F., Marques-Souza H.,
RA Tautz D., Tomoyasu Y., Trauner J., Van der Zee M., Vervoort M.,
RA Wittkopp N., Wimmer E.A., Yang X., Jones A.K., Sattelle D.B., Ebert P.R.,
RA Nelson D., Scott J.G., Beeman R.W., Muthukrishnan S., Kramer K.J.,
RA Arakane Y., Beeman R.W., Zhu Q., Hogenkamp D., Dixit R., Oppert B.,
RA Jiang H., Zou Z., Marshall J., Elpidina E., Vinokurov K., Oppert C.,
RA Zou Z., Evans J., Lu Z., Zhao P., Sumathipala N., Altincicek B.,
RA Vilcinskas A., Williams M., Hultmark D., Hetru C., Jiang H.,
RA Grimmelikhuijzen C.J., Hauser F., Cazzamali G., Williamson M., Park Y.,
RA Li B., Tanaka Y., Predel R., Neupert S., Schachtner J., Verleyen P.,
RA Raible F., Bork P., Friedrich M., Walden K.K., Robertson H.M., Angeli S.,
RA Foret S., Bucher G., Schuetz S., Maleszka R., Wimmer E.A., Beeman R.W.,
RA Lorenzen M., Tomoyasu Y., Miller S.C., Grossmann D., Bucher G.;
RT "The genome of the model beetle and pest Tribolium castaneum.";
RL Nature 452:949-955(2008).
RN [2] {ECO:0000313|EMBL:EFA03035.1, ECO:0000313|Proteomes:UP000007266}
RP GENOME REANNOTATION.
RC STRAIN=Georgia GA2 {ECO:0000313|EMBL:EFA03035.1,
RC ECO:0000313|Proteomes:UP000007266};
RX PubMed=19820115; DOI=10.1093/nar/gkp807;
RA Kim H.S., Murphy T., Xia J., Caragea D., Park Y., Beeman R.W.,
RA Lorenzen M.D., Butcher S., Manak J.R., Brown S.J.;
RT "BeetleBase in 2010: revisions to provide comprehensive genomic information
RT for Tribolium castaneum.";
RL Nucleic Acids Res. 38:D437-D442(2010).
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; KQ971342; EFA03035.1; -; Genomic_DNA.
DR RefSeq; XP_008200500.1; XM_008202278.2.
DR STRING; 7070.D6WKS5; -.
DR EnsemblMetazoa; TC010461_001; TC010461_001; TC010461.
DR GeneID; 662068; -.
DR KEGG; tca:662068; -.
DR eggNOG; KOG1217; Eukaryota.
DR eggNOG; KOG3509; Eukaryota.
DR HOGENOM; CLU_002251_0_0_1; -.
DR InParanoid; D6WKS5; -.
DR OMA; ECHRNEC; -.
DR OrthoDB; 101939at2759; -.
DR PhylomeDB; D6WKS5; -.
DR Proteomes; UP000007266; Linkage group 5.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IEA:UniProt.
DR GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR GO; GO:0048468; P:cell development; IEA:UniProt.
DR GO; GO:0016043; P:cellular component organization; IEA:UniProt.
DR CDD; cd00054; EGF_CA; 9.
DR CDD; cd00110; LamG; 4.
DR Gene3D; 2.60.120.200; -; 4.
DR Gene3D; 2.10.25.10; Laminin; 13.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR001791; Laminin_G.
DR PANTHER; PTHR24044:SF420; NEUROGENIC LOCUS PROTEIN DELTA; 1.
DR PANTHER; PTHR24044; NOTCH LIGAND FAMILY MEMBER; 1.
DR Pfam; PF00008; EGF; 6.
DR Pfam; PF12661; hEGF; 2.
DR Pfam; PF00054; Laminin_G_1; 1.
DR Pfam; PF02210; Laminin_G_2; 3.
DR PRINTS; PR00010; EGFBLOOD.
DR SMART; SM00181; EGF; 14.
DR SMART; SM00179; EGF_CA; 12.
DR SMART; SM00282; LamG; 4.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 4.
DR SUPFAM; SSF57196; EGF/Laminin; 10.
DR PROSITE; PS00010; ASX_HYDROXYL; 3.
DR PROSITE; PS00022; EGF_1; 13.
DR PROSITE; PS01186; EGF_2; 7.
DR PROSITE; PS50026; EGF_3; 13.
DR PROSITE; PS01187; EGF_CA; 2.
DR PROSITE; PS50025; LAM_G_DOMAIN; 4.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Reference proteome {ECO:0000313|Proteomes:UP000007266};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 28..1499
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003089874"
FT DOMAIN 27..63
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 65..101
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 103..139
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 141..181
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 183..219
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 221..257
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 259..296
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 491..528
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 535..712
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 708..741
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 744..781
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 791..975
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 976..1012
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1014..1052
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1058..1242
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 1238..1275
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1313..1496
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DISULFID 31..41
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 53..62
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 91..100
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 129..138
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 171..180
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 209..218
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 247..256
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 286..295
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 518..527
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 771..780
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1002..1011
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1042..1051
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1265..1274
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 1499 AA; 163954 MW; 372743BC7D53087E CRC64;
MPSVGSAGRS LFLLLAPFFL LPLESSAGLA CLSNPCVHGV CLDDLNSTYF CYCIDGYTGI
QCQKNWNECW SSPCKNGGIC IDGVASFNCS CPPGFVGELC EEDFNECESN PCLNNGTCLD
AANGYFCSCL PGYSGVHCEV DVAVCNATNE TRCANGGICV EGPGDSFSCK CQPGWEGLLC
EGEVDECMSA PCQNGAVCVD LMADYSCACL FGFSGRNCED TVKICDVNPC ANGALCLKED
RQPVCYCVPD FHGDLCQFQY DECQLGPKCM NGGTCVDGID NSTCSCPPNL TGVQCECLIL
DNGGLDCTYT SPQTVPPIRT STIFHPTTTE TEVPNTTTVQ PFSTTIAWTT TEVVPPTTTY
TQTQSTTELT ETILVYSTTP KVTEMSVVTT ETEPTTETTY STVTTTEIYT EPVFTTTTGK
IITTMLSTET SSFPPVTTFL PMTSTPKQES NFSLPDETTT SFFTKKPETT TALTAFFTET
TTKLLTDTTV VPFDCTKTHC QNGGTCVYKS ELGYQCLCPF HTEGDFCELK MGVQKAAFTG
QSYLKHRLPD STNISIELDA KTLSSKGLLF YSNTDSTYMV LYIENGHLKF KFSCGYQTML
LSELKVPVNN GDLMKIKAKL EFSKDLKRCD ASIKVNDSLS MTGDQLALKR RFSKPSGWLY
LGGVPEEIAN INLPESGFVG CMLRLKISQK FLDIFNDAED GYGVTECSSL ACLSNPCSNG
ATCYSHGEKW TCHCKNGFLG KMCEKSVCDT NPCLFGGTCI QFSGSGYICL CPFGKHGHFC
ENDLKITEPN FASTIRGLSS YVAYPIPGGI SENMEIRFRF LPTVMDQISL LMFMGQKGHH
NYYSDHMAVS FVKGYIMLTW NLGSGPRRIF TPQPIDEGAK NYQVRVGRSG RRAWLDVENL
GNVTGRSPGN LIQLDVSPVL YLGGHDSLNF STLPHDLPLH TGFSGCIFDV ELITGNLVIP
LQGSRQTIGR GVGQCGTTEC YEQSCQNGGI CLHHASTFMC LCQDGWFGPL CTFRRNPCDS
DYHKCEAGAT CVPVISDYEC DCPIGKSGKF CEKDEDITDV NFTGLRSFLS LPPTEFSENH
FNIEMEIRPL GDNGLLFFIE KPGSSFISLT LSSGSLELRI LSYKNKAAPN EPTTIRSTKI
LIKGIWYKIQ LGIFGKKAYL SVDNIINSAV LSTENGINMS KENIFIGGHP DISTLPLLAV
SKLPVPYKGC IRAFSANGVH IPLNKMSILS GRNINDCDGT PCGKDACLNG GTCWLDSFMK
PHCSCPPAFY GNKCQSVSEC DTAKCKTTGV CVGPKCSCHL GWEGVYCERQ IKVTTPEFTG
RSYLIVKKNN EKKRNTPGVE VKTLYLNFTT VKKDGLVLWS RKENSFVGMG LENGFLKIAY
SVDNRTGTNL VTLPLSYKIS DGLWHNIELS FAPFLIKLDQ NKIVYNGKNK KMLENSTMST
DGLFYIGGIP TKTTIKKETN GTFLDTFEGC IEGFATNGEQ VIRDFTPFEG RDVNVCRVV
//
