ID D6WN87_TRICA Unreviewed; 1491 AA.
AC D6WN87;
DT 10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT 10-AUG-2010, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:EFA03078.1};
GN Name=AUGUSTUS-3.0.2_10952 {ECO:0000313|EMBL:EFA03078.1};
GN ORFNames=TcasGA2_TC010952 {ECO:0000313|EMBL:EFA03078.1};
OS Tribolium castaneum (Red flour beetle).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Coleoptera; Polyphaga; Cucujiformia;
OC Tenebrionidae; Tenebrionidae incertae sedis; Tribolium.
OX NCBI_TaxID=7070 {ECO:0000313|EMBL:EFA03078.1, ECO:0000313|Proteomes:UP000007266};
RN [1] {ECO:0000313|EMBL:EFA03078.1, ECO:0000313|Proteomes:UP000007266}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Georgia GA2 {ECO:0000313|EMBL:EFA03078.1,
RC ECO:0000313|Proteomes:UP000007266};
RX PubMed=18362917; DOI=10.1038/nature06784;
RG Tribolium Genome Sequencing Consortium;
RA Richards S., Gibbs R.A., Weinstock G.M., Brown S.J., Denell R.,
RA Beeman R.W., Gibbs R., Beeman R.W., Brown S.J., Bucher G., Friedrich M.,
RA Grimmelikhuijzen C.J., Klingler M., Lorenzen M., Richards S., Roth S.,
RA Schroder R., Tautz D., Zdobnov E.M., Muzny D., Gibbs R.A., Weinstock G.M.,
RA Attaway T., Bell S., Buhay C.J., Chandrabose M.N., Chavez D.,
RA Clerk-Blankenburg K.P., Cree A., Dao M., Davis C., Chacko J., Dinh H.,
RA Dugan-Rocha S., Fowler G., Garner T.T., Garnes J., Gnirke A., Hawes A.,
RA Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N., Joshi V.,
RA Khan Z.M., Jackson L., Kovar C., Kowis A., Lee S., Lewis L.R., Margolis J.,
RA Morgan M., Nazareth L.V., Nguyen N., Okwuonu G., Parker D., Richards S.,
RA Ruiz S.J., Santibanez J., Savard J., Scherer S.E., Schneider B.,
RA Sodergren E., Tautz D., Vattahil S., Villasana D., White C.S., Wright R.,
RA Park Y., Beeman R.W., Lord J., Oppert B., Lorenzen M., Brown S., Wang L.,
RA Savard J., Tautz D., Richards S., Weinstock G., Gibbs R.A., Liu Y.,
RA Worley K., Weinstock G., Elsik C.G., Reese J.T., Elhaik E., Landan G.,
RA Graur D., Arensburger P., Atkinson P., Beeman R.W., Beidler J., Brown S.J.,
RA Demuth J.P., Drury D.W., Du Y.Z., Fujiwara H., Lorenzen M., Maselli V.,
RA Osanai M., Park Y., Robertson H.M., Tu Z., Wang J.J., Wang S., Richards S.,
RA Song H., Zhang L., Sodergren E., Werner D., Stanke M., Morgenstern B.,
RA Solovyev V., Kosarev P., Brown G., Chen H.C., Ermolaeva O., Hlavina W.,
RA Kapustin Y., Kiryutin B., Kitts P., Maglott D., Pruitt K., Sapojnikov V.,
RA Souvorov A., Mackey A.J., Waterhouse R.M., Wyder S., Zdobnov E.M.,
RA Zdobnov E.M., Wyder S., Kriventseva E.V., Kadowaki T., Bork P., Aranda M.,
RA Bao R., Beermann A., Berns N., Bolognesi R., Bonneton F., Bopp D.,
RA Brown S.J., Bucher G., Butts T., Chaumot A., Denell R.E., Ferrier D.E.,
RA Friedrich M., Gordon C.M., Jindra M., Klingler M., Lan Q., Lattorff H.M.,
RA Laudet V., von Levetsow C., Liu Z., Lutz R., Lynch J.A., da Fonseca R.N.,
RA Posnien N., Reuter R., Roth S., Savard J., Schinko J.B., Schmitt C.,
RA Schoppmeier M., Schroder R., Shippy T.D., Simonnet F., Marques-Souza H.,
RA Tautz D., Tomoyasu Y., Trauner J., Van der Zee M., Vervoort M.,
RA Wittkopp N., Wimmer E.A., Yang X., Jones A.K., Sattelle D.B., Ebert P.R.,
RA Nelson D., Scott J.G., Beeman R.W., Muthukrishnan S., Kramer K.J.,
RA Arakane Y., Beeman R.W., Zhu Q., Hogenkamp D., Dixit R., Oppert B.,
RA Jiang H., Zou Z., Marshall J., Elpidina E., Vinokurov K., Oppert C.,
RA Zou Z., Evans J., Lu Z., Zhao P., Sumathipala N., Altincicek B.,
RA Vilcinskas A., Williams M., Hultmark D., Hetru C., Jiang H.,
RA Grimmelikhuijzen C.J., Hauser F., Cazzamali G., Williamson M., Park Y.,
RA Li B., Tanaka Y., Predel R., Neupert S., Schachtner J., Verleyen P.,
RA Raible F., Bork P., Friedrich M., Walden K.K., Robertson H.M., Angeli S.,
RA Foret S., Bucher G., Schuetz S., Maleszka R., Wimmer E.A., Beeman R.W.,
RA Lorenzen M., Tomoyasu Y., Miller S.C., Grossmann D., Bucher G.;
RT "The genome of the model beetle and pest Tribolium castaneum.";
RL Nature 452:949-955(2008).
RN [2] {ECO:0000313|EMBL:EFA03078.1, ECO:0000313|Proteomes:UP000007266}
RP GENOME REANNOTATION.
RC STRAIN=Georgia GA2 {ECO:0000313|EMBL:EFA03078.1,
RC ECO:0000313|Proteomes:UP000007266};
RX PubMed=19820115; DOI=10.1093/nar/gkp807;
RA Kim H.S., Murphy T., Xia J., Caragea D., Park Y., Beeman R.W.,
RA Lorenzen M.D., Butcher S., Manak J.R., Brown S.J.;
RT "BeetleBase in 2010: revisions to provide comprehensive genomic information
RT for Tribolium castaneum.";
RL Nucleic Acids Res. 38:D437-D442(2010).
CC -!- SIMILARITY: Belongs to the CNKSR family.
CC {ECO:0000256|ARBA:ARBA00009498}.
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DR EMBL; KQ971342; EFA03078.1; -; Genomic_DNA.
DR RefSeq; XP_970755.2; XM_965662.4.
DR STRING; 7070.D6WN87; -.
DR EnsemblMetazoa; TC010952_001; TC010952_001; TC010952.
DR GeneID; 659345; -.
DR KEGG; tca:659345; -.
DR eggNOG; KOG1738; Eukaryota.
DR HOGENOM; CLU_244038_0_0_1; -.
DR InParanoid; D6WN87; -.
DR OMA; RMFHEVR; -.
DR OrthoDB; 5406576at2759; -.
DR PhylomeDB; D6WN87; -.
DR Proteomes; UP000007266; Linkage group 5.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd13326; PH_CNK_insect-like; 1.
DR CDD; cd09511; SAM_CNK1_2_3-suppressor; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR InterPro; IPR049628; CNK1-3_SAM.
DR InterPro; IPR017874; CRIC_domain.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR PANTHER; PTHR12844; CONNECTOR ENCHANCER OF KINASE SUPPRESSOR OF RAS; 1.
DR PANTHER; PTHR12844:SF42; CONNECTOR ENHANCER OF KSR PROTEIN CNK; 1.
DR Pfam; PF10534; CRIC_ras_sig; 1.
DR Pfam; PF00595; PDZ; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00536; SAM_1; 1.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00454; SAM; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR PROSITE; PS51290; CRIC; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000007266}.
FT DOMAIN 9..74
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT DOMAIN 82..169
FT /note="CRIC"
FT /evidence="ECO:0000259|PROSITE:PS51290"
FT DOMAIN 206..286
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 836..935
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 349..377
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 562..608
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 944..996
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1174..1207
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1225..1260
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1290..1341
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1416..1491
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 951..991
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1174..1198
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1246..1260
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1320..1341
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1416..1439
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1472..1491
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1491 AA; 168003 MW; DDA2DFB08F4B6CCD CRC64;
MAYVNVRDWS VDQVTDWLKG LDSIILQYTT SFLNNGVTGH QLLNLRADDL DNLGVKSLGH
QELILESVEH LRHFHFELDK ENLQMLALKV SCASNSLYKE LLLVDDNCPI VSPQMMSDVH
NIIMTIKPLV CWLDRAPFLG DKDYIDCKTQ LLDLSFEMAT RAHRGKFSEK PVSFIKDICE
RITKLADHII QEISDPMVLQ PASLDLATLK KKEQELGFFI SPNNHAVHQI AEIKYGSPAH
GSSKIEEGDE IVQVNYQTVV GWQRKNVMIL LQDSPPEIVL TLKKRPRHTK VYGQIYMKPY
RLPSKKLDGQ TYFRWNDSIP PSRLLPMHSL SPIDIPKLPV VIEPPDVEIE LSSSDDSEPP
DSPLDGSGRM YPLKPRPILQ RRNTITGPIP TSKTPYPYME KYWQNLKDRA VSTHSSSVNI
DDTNFETDSS FIRDKSASCN LGLELSPRPT TVIGIGQSRN KSFKNDFKEK PAKKRVIFQE
KKPEDVEKTS NLNEEKSVSV NSLASLNNTS IAFIDEGRDL TDRTSMVTEK DAALADVNIH
DIIKKFDEKE IVVKPKIFPR SQIKKPPDVP QKPDQSKKPV VPPRSVTTKV RGRLDKSHST
PAYDLTGDEN SPVEKFVVKK VQTEVVEHVT STVSESEPFS EMKYELGIPI VDAISLPLTQ
TVPVVEEIKI TLTEKTEIKQ GIDEDLPPKP PPRTFGVVDF NKPAYPIDSP KPNISEKLKG
DLAAKSTVFE YLDTKHTYST EVTTVSKPPE SPALLKESNK LQNKFFEPKT ASTPKKSDFG
ESVPSFEVPK NMSESKISPT NSIVRAMIYS NKNKAGKKKN TITAKRRRVT VNDLNPPDTQ
GYLYQRLRSK HNQNVHWEKR WFVLLGSCLY GFKTKEDPRA ACLIFLSGFT VAVASEVKSR
SNAFKVYHTG TVFYFSAEDP ETLQSWIETI TAATLNNDSL KTADGSLYSE TDESDTEKPK
KTEPEKNPET IKKFNSLKKL TKKHENAAGG STSLDRKRFF NKSSSHSKNS LPVPTAQFRS
YRKIKTTETP SGSVTTGNFT SHVASFFAHR SEIPQFQQSV QNVSVPNLTV EHLGKGQEKA
SGKLSKVKPL NYVHASNPSL CNINDFHVPN FPKKTFKQCN ENLAGFVTLE ELMIKQSEEK
KLNPYNMADD VFMNLNLIKP DVVYGEVPIR PKEKVEVEEK PEPTFKKGHT RNASDSQKSS
EKQDFGSSCF GKRLGSFKKI HKESDDFENR TSTYPKTAKG FDQKLNRSLP RTHKLSENAD
VSRYASDRNL ASERGYEMIY CPETTTDVQF AQNRNLDDRM YKETPKKGHK IKKQNSFNPS
DKKTGKSGPD SAKYTNKVSD SSKVKLKSAI QYTPMCLPLS QDEKSKPKLA FELNLDEKST
KGGKFKQIFG KQSEGKKEKT FLGSPKLHRT IFRKNNSSSE LNWPSTSTQA VLPQSSYSVE
NSPPEPPPVS ISPHADYPGL EYPPVFEPET YSLADPQSSL TLLRKQGKSN N
//