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Database: UniProt
Entry: D6WRS1_TRICA
LinkDB: D6WRS1_TRICA
Original site: D6WRS1_TRICA 
ID   D6WRS1_TRICA            Unreviewed;      1954 AA.
AC   D6WRS1;
DT   10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT   11-MAY-2016, sequence version 2.
DT   07-JUN-2017, entry version 49.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   ORFNames=TcasGA2_TC008776 {ECO:0000313|EMBL:EFA05958.2};
OS   Tribolium castaneum (Red flour beetle).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Coleoptera; Polyphaga;
OC   Cucujiformia; Tenebrionidae; Tenebrionidae incertae sedis; Tribolium.
OX   NCBI_TaxID=7070 {ECO:0000313|EMBL:EFA05958.2, ECO:0000313|Proteomes:UP000007266};
RN   [1] {ECO:0000313|EMBL:EFA05958.2, ECO:0000313|Proteomes:UP000007266}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Georgia GA2 {ECO:0000313|EMBL:EFA05958.2,
RC   ECO:0000313|Proteomes:UP000007266};
RX   PubMed=18362917; DOI=10.1038/nature06784;
RG   Tribolium Genome Sequencing Consortium;
RA   Richards S., Gibbs R.A., Weinstock G.M., Brown S.J., Denell R.,
RA   Beeman R.W., Gibbs R., Beeman R.W., Brown S.J., Bucher G.,
RA   Friedrich M., Grimmelikhuijzen C.J., Klingler M., Lorenzen M.,
RA   Richards S., Roth S., Schroder R., Tautz D., Zdobnov E.M., Muzny D.,
RA   Gibbs R.A., Weinstock G.M., Attaway T., Bell S., Buhay C.J.,
RA   Chandrabose M.N., Chavez D., Clerk-Blankenburg K.P., Cree A., Dao M.,
RA   Davis C., Chacko J., Dinh H., Dugan-Rocha S., Fowler G., Garner T.T.,
RA   Garnes J., Gnirke A., Hawes A., Hernandez J., Hines S., Holder M.,
RA   Hume J., Jhangiani S.N., Joshi V., Khan Z.M., Jackson L., Kovar C.,
RA   Kowis A., Lee S., Lewis L.R., Margolis J., Morgan M., Nazareth L.V.,
RA   Nguyen N., Okwuonu G., Parker D., Richards S., Ruiz S.J.,
RA   Santibanez J., Savard J., Scherer S.E., Schneider B., Sodergren E.,
RA   Tautz D., Vattahil S., Villasana D., White C.S., Wright R., Park Y.,
RA   Beeman R.W., Lord J., Oppert B., Lorenzen M., Brown S., Wang L.,
RA   Savard J., Tautz D., Richards S., Weinstock G., Gibbs R.A., Liu Y.,
RA   Worley K., Weinstock G., Elsik C.G., Reese J.T., Elhaik E., Landan G.,
RA   Graur D., Arensburger P., Atkinson P., Beeman R.W., Beidler J.,
RA   Brown S.J., Demuth J.P., Drury D.W., Du Y.Z., Fujiwara H.,
RA   Lorenzen M., Maselli V., Osanai M., Park Y., Robertson H.M., Tu Z.,
RA   Wang J.J., Wang S., Richards S., Song H., Zhang L., Sodergren E.,
RA   Werner D., Stanke M., Morgenstern B., Solovyev V., Kosarev P.,
RA   Brown G., Chen H.C., Ermolaeva O., Hlavina W., Kapustin Y.,
RA   Kiryutin B., Kitts P., Maglott D., Pruitt K., Sapojnikov V.,
RA   Souvorov A., Mackey A.J., Waterhouse R.M., Wyder S., Zdobnov E.M.,
RA   Zdobnov E.M., Wyder S., Kriventseva E.V., Kadowaki T., Bork P.,
RA   Aranda M., Bao R., Beermann A., Berns N., Bolognesi R., Bonneton F.,
RA   Bopp D., Brown S.J., Bucher G., Butts T., Chaumot A., Denell R.E.,
RA   Ferrier D.E., Friedrich M., Gordon C.M., Jindra M., Klingler M.,
RA   Lan Q., Lattorff H.M., Laudet V., von Levetsow C., Liu Z., Lutz R.,
RA   Lynch J.A., da Fonseca R.N., Posnien N., Reuter R., Roth S.,
RA   Savard J., Schinko J.B., Schmitt C., Schoppmeier M., Schroder R.,
RA   Shippy T.D., Simonnet F., Marques-Souza H., Tautz D., Tomoyasu Y.,
RA   Trauner J., Van der Zee M., Vervoort M., Wittkopp N., Wimmer E.A.,
RA   Yang X., Jones A.K., Sattelle D.B., Ebert P.R., Nelson D., Scott J.G.,
RA   Beeman R.W., Muthukrishnan S., Kramer K.J., Arakane Y., Beeman R.W.,
RA   Zhu Q., Hogenkamp D., Dixit R., Oppert B., Jiang H., Zou Z.,
RA   Marshall J., Elpidina E., Vinokurov K., Oppert C., Zou Z., Evans J.,
RA   Lu Z., Zhao P., Sumathipala N., Altincicek B., Vilcinskas A.,
RA   Williams M., Hultmark D., Hetru C., Jiang H., Grimmelikhuijzen C.J.,
RA   Hauser F., Cazzamali G., Williamson M., Park Y., Li B., Tanaka Y.,
RA   Predel R., Neupert S., Schachtner J., Verleyen P., Raible F., Bork P.,
RA   Friedrich M., Walden K.K., Robertson H.M., Angeli S., Foret S.,
RA   Bucher G., Schuetz S., Maleszka R., Wimmer E.A., Beeman R.W.,
RA   Lorenzen M., Tomoyasu Y., Miller S.C., Grossmann D., Bucher G.;
RT   "The genome of the model beetle and pest Tribolium castaneum.";
RL   Nature 452:949-955(2008).
RN   [2] {ECO:0000313|EMBL:EFA05958.2, ECO:0000313|Proteomes:UP000007266}
RP   GENOME REANNOTATION.
RC   STRAIN=Georgia GA2 {ECO:0000313|EMBL:EFA05958.2,
RC   ECO:0000313|Proteomes:UP000007266};
RX   PubMed=19820115; DOI=10.1093/nar/gkp807;
RA   Kim H.S., Murphy T., Xia J., Caragea D., Park Y., Beeman R.W.,
RA   Lorenzen M.D., Butcher S., Manak J.R., Brown S.J.;
RT   "BeetleBase in 2010: revisions to provide comprehensive genomic
RT   information for Tribolium castaneum.";
RL   Nucleic Acids Res. 38:D437-D442(2010).
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
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DR   EMBL; KQ971354; EFA05958.2; -; Genomic_DNA.
DR   STRING; 7070.TC008776-PA; -.
DR   EnsemblMetazoa; TC008776_001; TC008776_001; TC008776.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   InParanoid; D6WRS1; -.
DR   Proteomes; UP000007266; Linkage group 7.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR028820; Na_channel_60E.
DR   InterPro; IPR001696; Na_channel_asu.
DR   PANTHER; PTHR10037:SF257; PTHR10037:SF257; 1.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00170; NACHANNEL.
DR   PROSITE; PS50096; IQ; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000007266};
KW   Ion channel {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000313|EMBL:EFA05958.2};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007266};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    127    151       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    510    534       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    554    585       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    643    668       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    975    993       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1005   1026       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1032   1054       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1086   1112       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1204   1228       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1290   1310       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1316   1337       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1349   1368       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1406   1439       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1506   1529       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN        1    158       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      445    675       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      973   1237       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1289   1539       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1545   1606       GPHH. {ECO:0000259|Pfam:PF16905}.
SQ   SEQUENCE   1954 AA;  222466 MW;  682005DE824AA41F CRC64;
     MTLTIFCLMV FALFALQVYK GELRNKCVLK MEDHNATYET WFNWTSDPNN WIVRNETGEP
     LLCGNVTGSR HCPSTHTCIC VGENPNHGYT SFDNFLWSML TTFQLITLDY WENVYNMVLS
     SCGPISVSFF TVVVFFGSFY LINLMLAVVA LSYEEEAEIT QEERKKELVD HREDSTFSFD
     PSSLNVKKLS KHKIKKIDAR KGVLLSSYTR KKTRRRKRNR STNNPNKSPS SSAAVEAANA
     KEDSKDSAKT SPKPNRSVTP SPSPSPRHSR SSSRPQMLPL PLPPPRHVQL SDPRCPDTLH
     PSNTLAPTRT GLSSRQASSN SGEGNNRESS LDDSGVVDDH ETEGDATSED VASHLPQQLP
     RQRVEVTPVT VALSPKEIKV IKCNGVGSCK KKKQMYSLPP DYLSHIVVID DQIPDRNCSG
     CEQCCVDYDG WLQFQQALYR IVRDPLFELA ITVCIVLNTM FLAMEHHGMS DDVLKALDIG
     NKVFTSIFTF ECCLKLMALS KEFFYCGWNI FDLIIVSASV LDLIFELVDG LSVLRGLRLL
     RVLKLAQSWI TMKVLLSIII STIGALGNLT FVLVIVIYIF AVIGMQLFAK DYTPEKFYPD
     PVPRWNFTDF FHSFMMIFRI LCGEWIEPLW DCMRAESTEG PGTCLAVFLP TLVMGNFMVL
     NLFLALLLNS FNSEELKTRK EEVGDESKLA QSFERIRDLI RKRRQQRMQE QKQNENNSRL
     EQIVREVMQR RAEEEAFKTG ITTKAIQETV VGFPRDKRSY QEAMNRPISI ISYDHPPDYQ
     TIQEGENEEK YARRYSTLIN GNSEESDNAE KTRLIENKKT DVRLLQNMSS GRGTTNDSKE
     ENTESVEMKN IDRGTSADTE HDEESALCPD SHKNCNRRGE HEDDSQKPWQ TLVSYVDELT
     VGGRRNSKGQ YIDGMGNFPG FGNKKPPKVP PNCFPHHCYQ QCACFNYCLN TSVGKKWTMI
     RTMVLRVVDT PGFEWFILVL IFASSVTLCF EDIHLDESPD LKSVLYWTNL AFSIIFIIEM
     LLKWIALGFH KYFTSFWTLL DFLIVFVSLF SLLIEENENL RVLRSLRTLR ALRPLRAISR
     WQGMRIVVNA LMYAIPSIFN VLLVCLVFWL IFSIMGVQFF RGKFYKCLDE NDELVPIEIV
     NTRLDCLTLN YTWINSKISF DHVGIAYLAL FQVATFEGWM EVMADAVDAR GVDLQPQREA
     NLYAYIYFVI FIVCGSFFTL NLFIGVIIDN FNMLKKKYEG GVLEMFLTES QKHYYTAMKK
     LGRKKPQKVI KRPMNQFLAM FYDLSNSRRF EIAIFVLIFL NMLSMGIEHY NQPHAVFFIL
     EVSNAFFTTV FGLEAIVKII GLRYHYFTVP WNVFDFLLVL ASILGILMED IMIDFPVSPT
     LLRVVRVFRI GRILRLIKAA KGIRKLLFAL VVSLPALFNI GALLALITFI YAIIGMFLFG
     HVKQQGALDD MVNFQTFGRS MHLLFRLITS AGWNDVLESL MIEPPECDPH YRNQSNGDCG
     YPLLSIIYFT SFIIINYMIV INMYIAIILE NFNQAHQEEE IGIVEDDLEM FYIRWSKYDP
     HATQFIRFSQ LSDFIASLDP PLGISKPNTV ALVSFNLPIA KGNKIHCLDI LHALVKHVLG
     HVEETDNFRQ LQEQMDIKFK KQFPTRKELE IVSSTRIWKR QDKAARLIQK TFRDYVKRKK
     ERERVQEEVD EMTQTSSPGG GWQGRLSAFL HVHRGSRASS RKSSRASDAS DLSELGGPWL
     NLPLLLLSSA TNMDPEELDL TRDAADVNIK VSEATPEATT PVCAPPPARR RSIYNFPFFL
     RHQDAVEKPD DSASPPASKR SAQSLHPAMA EDPKPKRGSI IRRKRVGSVK ARPTGGGITP
     AHRAESEPLN SADVSILVTE ASPEAPILKP PLQRQQSEAT VVQVLVHRES EEYNQDDDEA
     TPTIKVTPED ACDTDLTQVS GADANNQNGN TTDS
//
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