ID D6WYF4_TRICA Unreviewed; 1335 AA.
AC D6WYF4;
DT 10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT 11-MAY-2016, sequence version 2.
DT 27-MAR-2024, entry version 66.
DE RecName: Full=UBA domain-containing protein {ECO:0000259|PROSITE:PS50030};
GN Name=AUGUSTUS-3.0.2_06679 {ECO:0000313|EMBL:EFA08972.2};
GN ORFNames=TcasGA2_TC006679 {ECO:0000313|EMBL:EFA08972.2};
OS Tribolium castaneum (Red flour beetle).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Coleoptera; Polyphaga; Cucujiformia;
OC Tenebrionidae; Tenebrionidae incertae sedis; Tribolium.
OX NCBI_TaxID=7070 {ECO:0000313|EMBL:EFA08972.2, ECO:0000313|Proteomes:UP000007266};
RN [1] {ECO:0000313|EMBL:EFA08972.2, ECO:0000313|Proteomes:UP000007266}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Georgia GA2 {ECO:0000313|EMBL:EFA08972.2,
RC ECO:0000313|Proteomes:UP000007266};
RX PubMed=18362917; DOI=10.1038/nature06784;
RG Tribolium Genome Sequencing Consortium;
RA Richards S., Gibbs R.A., Weinstock G.M., Brown S.J., Denell R.,
RA Beeman R.W., Gibbs R., Beeman R.W., Brown S.J., Bucher G., Friedrich M.,
RA Grimmelikhuijzen C.J., Klingler M., Lorenzen M., Richards S., Roth S.,
RA Schroder R., Tautz D., Zdobnov E.M., Muzny D., Gibbs R.A., Weinstock G.M.,
RA Attaway T., Bell S., Buhay C.J., Chandrabose M.N., Chavez D.,
RA Clerk-Blankenburg K.P., Cree A., Dao M., Davis C., Chacko J., Dinh H.,
RA Dugan-Rocha S., Fowler G., Garner T.T., Garnes J., Gnirke A., Hawes A.,
RA Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N., Joshi V.,
RA Khan Z.M., Jackson L., Kovar C., Kowis A., Lee S., Lewis L.R., Margolis J.,
RA Morgan M., Nazareth L.V., Nguyen N., Okwuonu G., Parker D., Richards S.,
RA Ruiz S.J., Santibanez J., Savard J., Scherer S.E., Schneider B.,
RA Sodergren E., Tautz D., Vattahil S., Villasana D., White C.S., Wright R.,
RA Park Y., Beeman R.W., Lord J., Oppert B., Lorenzen M., Brown S., Wang L.,
RA Savard J., Tautz D., Richards S., Weinstock G., Gibbs R.A., Liu Y.,
RA Worley K., Weinstock G., Elsik C.G., Reese J.T., Elhaik E., Landan G.,
RA Graur D., Arensburger P., Atkinson P., Beeman R.W., Beidler J., Brown S.J.,
RA Demuth J.P., Drury D.W., Du Y.Z., Fujiwara H., Lorenzen M., Maselli V.,
RA Osanai M., Park Y., Robertson H.M., Tu Z., Wang J.J., Wang S., Richards S.,
RA Song H., Zhang L., Sodergren E., Werner D., Stanke M., Morgenstern B.,
RA Solovyev V., Kosarev P., Brown G., Chen H.C., Ermolaeva O., Hlavina W.,
RA Kapustin Y., Kiryutin B., Kitts P., Maglott D., Pruitt K., Sapojnikov V.,
RA Souvorov A., Mackey A.J., Waterhouse R.M., Wyder S., Zdobnov E.M.,
RA Zdobnov E.M., Wyder S., Kriventseva E.V., Kadowaki T., Bork P., Aranda M.,
RA Bao R., Beermann A., Berns N., Bolognesi R., Bonneton F., Bopp D.,
RA Brown S.J., Bucher G., Butts T., Chaumot A., Denell R.E., Ferrier D.E.,
RA Friedrich M., Gordon C.M., Jindra M., Klingler M., Lan Q., Lattorff H.M.,
RA Laudet V., von Levetsow C., Liu Z., Lutz R., Lynch J.A., da Fonseca R.N.,
RA Posnien N., Reuter R., Roth S., Savard J., Schinko J.B., Schmitt C.,
RA Schoppmeier M., Schroder R., Shippy T.D., Simonnet F., Marques-Souza H.,
RA Tautz D., Tomoyasu Y., Trauner J., Van der Zee M., Vervoort M.,
RA Wittkopp N., Wimmer E.A., Yang X., Jones A.K., Sattelle D.B., Ebert P.R.,
RA Nelson D., Scott J.G., Beeman R.W., Muthukrishnan S., Kramer K.J.,
RA Arakane Y., Beeman R.W., Zhu Q., Hogenkamp D., Dixit R., Oppert B.,
RA Jiang H., Zou Z., Marshall J., Elpidina E., Vinokurov K., Oppert C.,
RA Zou Z., Evans J., Lu Z., Zhao P., Sumathipala N., Altincicek B.,
RA Vilcinskas A., Williams M., Hultmark D., Hetru C., Jiang H.,
RA Grimmelikhuijzen C.J., Hauser F., Cazzamali G., Williamson M., Park Y.,
RA Li B., Tanaka Y., Predel R., Neupert S., Schachtner J., Verleyen P.,
RA Raible F., Bork P., Friedrich M., Walden K.K., Robertson H.M., Angeli S.,
RA Foret S., Bucher G., Schuetz S., Maleszka R., Wimmer E.A., Beeman R.W.,
RA Lorenzen M., Tomoyasu Y., Miller S.C., Grossmann D., Bucher G.;
RT "The genome of the model beetle and pest Tribolium castaneum.";
RL Nature 452:949-955(2008).
RN [2] {ECO:0000313|EMBL:EFA08972.2, ECO:0000313|Proteomes:UP000007266}
RP GENOME REANNOTATION.
RC STRAIN=Georgia GA2 {ECO:0000313|EMBL:EFA08972.2,
RC ECO:0000313|Proteomes:UP000007266};
RX PubMed=19820115; DOI=10.1093/nar/gkp807;
RA Kim H.S., Murphy T., Xia J., Caragea D., Park Y., Beeman R.W.,
RA Lorenzen M.D., Butcher S., Manak J.R., Brown S.J.;
RT "BeetleBase in 2010: revisions to provide comprehensive genomic information
RT for Tribolium castaneum.";
RL Nucleic Acids Res. 38:D437-D442(2010).
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DR EMBL; KQ971362; EFA08972.2; -; Genomic_DNA.
DR RefSeq; XP_008197256.1; XM_008199034.2.
DR RefSeq; XP_008197257.1; XM_008199035.2.
DR STRING; 7070.D6WYF4; -.
DR EnsemblMetazoa; TC006679_001; TC006679_001; TC006679.
DR GeneID; 661812; -.
DR KEGG; tca:661812; -.
DR eggNOG; ENOG502QWFQ; Eukaryota.
DR HOGENOM; CLU_001298_0_0_1; -.
DR InParanoid; D6WYF4; -.
DR OMA; VSWPPEF; -.
DR OrthoDB; 5407035at2759; -.
DR Proteomes; UP000007266; Linkage group 8.
DR GO; GO:0005654; C:nucleoplasm; IBA:GO_Central.
DR GO; GO:0000932; C:P-body; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0035278; P:miRNA-mediated gene silencing by inhibition of translation; IEA:InterPro.
DR GO; GO:0035195; P:miRNA-mediated post-transcriptional gene silencing; IBA:GO_Central.
DR GO; GO:0060213; P:positive regulation of nuclear-transcribed mRNA poly(A) tail shortening; IBA:GO_Central.
DR CDD; cd12435; RRM_GW182_like; 1.
DR CDD; cd14284; UBA_GAWKY; 1.
DR Gene3D; 3.30.70.330; -; 1.
DR Gene3D; 1.10.8.10; DNA helicase RuvA subunit, C-terminal domain; 1.
DR InterPro; IPR041971; Gawky_UBA.
DR InterPro; IPR026805; GW182_M_dom.
DR InterPro; IPR033503; GW182_RRM.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR InterPro; IPR015940; UBA.
DR InterPro; IPR009060; UBA-like_sf.
DR PANTHER; PTHR13020:SF25; PROTEIN GAWKY; 1.
DR PANTHER; PTHR13020; TRINUCLEOTIDE REPEAT-CONTAINING GENE 6; 1.
DR Pfam; PF12938; M_domain; 1.
DR Pfam; PF00076; RRM_1; 1.
DR SMART; SM00360; RRM; 1.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 1.
DR SUPFAM; SSF46934; UBA-like; 1.
DR PROSITE; PS50030; UBA; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000007266};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884};
KW Translation regulation {ECO:0000256|ARBA:ARBA00022845}.
FT DOMAIN 665..705
FT /note="UBA"
FT /evidence="ECO:0000259|PROSITE:PS50030"
FT REGION 159..305
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 322..482
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 540..577
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 957..1058
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1075..1130
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1271..1335
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 177..305
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 323..337
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 407..425
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 461..479
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 554..577
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 969..993
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1011..1028
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1271..1324
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1335 AA; 142600 MW; 5500E054B1D92B55 CRC64;
MRAPTPSEPK STFPTYQVPQ VSAMRGSAPP VQVARAAWGG RADPPSQPIA AKGATSVING
SSCRLNGNSN IRMQSVTENC LLNSVTVPKI QRKDHCKVAH NNSDKLVCKF GALPLGRDIP
NQKSDDLEVL DLNALKNLTS CDNNDEHCDD DEMCREPHVQ RTSDNHTPPL RLRGGGESSL
STGTSGWGTP PSQQASNNNA NTSSGWGTAN PANQNNTGTQ QWNNNANRPP TSSQGPTQDA
NKANSNLNSN GQQQTPASQP NNSSWGQPGA KPPTTNNGPQ PTTSTSSAKP PNPTAQPNTT
TSTKQQLEQL NNMREAIFSQ DGWGGQHVNQ DTNWDIPGSP EPSMKMDGSA PPPWKPAINN
GTELWEANLR NGGQPPPQPQ QKTPWGHTPS TNIGGTWGED DDADSSNVWT GVPSGQQQWG
NTANSGGMWG GPKKESEWGA AAGNPGWGDP RTATDPRATG GIDPRDMRPD LRDMRAGSSD
PMRLLDPREQ MRLAGSDMRG DPRGITGRLN GAGAADAFWG QAGPHTGTQH IHHQNKMPVG
PGNGAGWEEP SPPTQRRNMP NYDDGTSLWG NPQQGSHWKD LPTGASMGRG STAGPPGMAQ
SRIKPDGSVW CHGRNGSWDE TGPGWDESVG GWNKQKMAGT HLWGDNEIDW GHNKGPKQNL
TKEMIWNSKC FRMLMDMGYK KEDVETALRR GDMNYEDALE ILGSRNPDGW RNRHDDHYDH
QQFPGQRFPS GPPGQMSFPQ GNNAPNLLNN MNSSGGPNNS LINNISPAGV HKMLTQGGGG
SQGFGAVSAA GRNLQPQSQP STQQLRMLVQ QIQMAVQAGY LNHQILNQPL APQTLILLNQ
LLQQIKTLQQ LMTQQSVAQS QCINGKPNSA LLQCSVLITK TKQQITNLQN QIAAQQAIYV
KQQNHGSIGG GQSDLFKTAA PMHDSINALQ SNFADLGIKD QVNQSQSRLN QWINKDKEEG
GEFSRAPGSS SKPLATSPNM NPLGLTQPDG PWSSGRTGDG GWPESGGGDS SNDGKDAQWP
TPTQPSLSDL VPEFEPGKPW KGNQIKSIED DPSITPGSVV RSSLSIATIK DTELFQMNPN
NKSPPAGDTI QPLSLSSSTW SFNPPSSTSS AFTSPQNKLP SSKSGLGELN PTTAVTSELW
AAPKSRGPPP GLSAKGGALV NGWSSAASWG GGQRGSGSWG GSPWLLLRNL TAQIDGSTLR
TLCMQHGPLQ SFHLYLHQGF ALAKYSTREE ATKAQTALNN CVLGNTTILA ENPSEWDANA
LLQQVASQQS SSGAWRGSTK QPSTGSDTWS TGWSNSQSSA SLWGSTTLDT TDPARATPSS
LNSFLPGDLL GGESM
//