ID D6XU43_BACIE Unreviewed; 855 AA.
AC D6XU43;
DT 10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT 10-AUG-2010, sequence version 1.
DT 27-MAR-2024, entry version 85.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN OrderedLocusNames=Bsel_1822 {ECO:0000313|EMBL:ADH99329.1};
OS Bacillus selenitireducens (strain ATCC 700615 / DSM 15326 / MLS10).
OC Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae;
OC Salisediminibacterium.
OX NCBI_TaxID=439292 {ECO:0000313|EMBL:ADH99329.1, ECO:0000313|Proteomes:UP000000271};
RN [1] {ECO:0000313|EMBL:ADH99329.1, ECO:0000313|Proteomes:UP000000271}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700615 / DSM 15326 / MLS10
RC {ECO:0000313|Proteomes:UP000000271};
RG US DOE Joint Genome Institute;
RA Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA Bruce D., Goodwin L., Pitluck S., Sims D., Brettin T., Detter J.C., Han C.,
RA Larimer F., Land M., Hauser L., Kyrpides N., Ovchinnikova G., Stolz J.;
RT "Complete sequence of Bacillus selenitireducens MLS10.";
RL Submitted (OCT-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000256|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|HAMAP-Rule:MF_00096,
CC ECO:0000256|RuleBase:RU003756}.
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DR EMBL; CP001791; ADH99329.1; -; Genomic_DNA.
DR RefSeq; WP_013172753.1; NC_014219.1.
DR AlphaFoldDB; D6XU43; -.
DR STRING; 439292.Bsel_1822; -.
DR KEGG; bse:Bsel_1822; -.
DR eggNOG; COG0249; Bacteria.
DR HOGENOM; CLU_002472_3_1_9; -.
DR OrthoDB; 9802448at2; -.
DR Proteomes; UP000000271; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd03284; ABC_MutS1; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 2.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00096}; Coiled coil {ECO:0000256|SAM:Coils};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00096}.
FT DOMAIN 678..694
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT COILED 484..515
FT /evidence="ECO:0000256|SAM:Coils"
FT BINDING 604..611
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00096"
SQ SEQUENCE 855 AA; 96021 MW; 03B3A4C3CC67CE36 CRC64;
MANTPMMEQY LRIKNDYQDA FLFFRLGDFY ELFFEDAKRA AKELEITLTA RGKGEDKIPM
CGVPHHSSKQ YIRQLIEKGF KVAICEQTED PAQAKGVVRR EVVQVITPGT VMDTGAFDDK
ENNFLIALSE SSDNRETALA ALDTTTGEFR LTKLDSNDAL ISELAVYQCR EVVIDDSIDE
DALNALIEPM GMTVSKVTIT PGSSPPHAVS KVEDYELLRV ADVLFHYVGH TAGGALEHVQ
MADVYIRQAY MHMDAHSKRN LELTGTLRDR RKQGSLLGVI DETSTAMGGR LLKQWINKPL
LNIDQISSRQ RIVRSLMDYF FERQSLKTAL QGVYDLERLS GRVAFGNVNG RDFIQLKHSL
EKVPQILDLI RDIAGDDSMP LIEGAETCDE LRELLEVSIQ ENCPVSITEG DLLKDGYDEQ
LDLYREAMSN GKSWIAELER QERAHTGIKS LKVGFNKVFG YYIEVTKANI AALPEGRYER
KQTLSNAERY ITEELKEKEQ LILEAEEKSV KLEHELFLEI RDRVKAYIRP LQKLAKTISA
VDVLVSFAEV SEQNGYVQPT LKANGPVKVI HGRHPVVETM IDHGDYVAND LTMDEDKDIL
LITGPNMAGK STYMRQLAHL SILAQIGCFV PADEAELPVF DQIFTRIGAA DDLAQGQSTF
MVEMLETRQA LKHATRQSLI LLDEIGRGTS TYDGMSLAQA VIEYVHDTVQ AKTLFSTHYH
ELTQLADNLE RCHNVHVAAR EEDGEVVFLH KVIDGPADRS YGIYVAQLAE LPREVIERAK
ELLADFEAQA QEVSTSSAVP SARDEQIPLF DASVMESERT GKEKEVLAAI QNLNLLHLTP
IQAIQILDDL KQKLT
//
