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Database: UniProt
Entry: D6Y203_THEBD
LinkDB: D6Y203_THEBD
Original site: D6Y203_THEBD 
ID   D6Y203_THEBD            Unreviewed;       527 AA.
AC   D6Y203;
DT   10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT   10-AUG-2010, sequence version 1.
DT   27-SEP-2017, entry version 55.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377,
GN   ECO:0000313|EMBL:ADG86738.1};
GN   OrderedLocusNames=Tbis_0001 {ECO:0000313|EMBL:ADG86738.1};
OS   Thermobispora bispora (strain ATCC 19993 / DSM 43833 / CBS 139.67 /
OS   JCM 10125 / NBRC 14880 / R51).
OC   Bacteria; Actinobacteria; Actinobacteria incertae sedis;
OC   Thermobispora.
OX   NCBI_TaxID=469371 {ECO:0000313|EMBL:ADG86738.1, ECO:0000313|Proteomes:UP000006640};
RN   [1] {ECO:0000313|EMBL:ADG86738.1, ECO:0000313|Proteomes:UP000006640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 19993 / DSM 43833 / CBS 139.67 / JCM 10125 / NBRC 14880 /
RC   R51 {ECO:0000313|Proteomes:UP000006640};
RG   US DOE Joint Genome Institute (JGI-PGF);
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E.,
RA   Tice H., Bruce D., Goodwin L., Pitluck S., Kyrpides N., Mavromatis K.,
RA   Ivanova N., Mikhailova N., Chertkov O., Brettin T., Detter J.C.,
RA   Han C., Larimer F., Land M., Hauser L., Markowitz V., Cheng J.-F.,
RA   Hugenholtz P., Woyke T., Wu D., Jando M., Schneider S., Klenk H.-P.,
RA   Eisen J.A.;
RT   "The complete genome of Thermobispora bispora DSM 43833.";
RL   Submitted (JAN-2010) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731907}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
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DR   EMBL; CP001874; ADG86738.1; -; Genomic_DNA.
DR   RefSeq; WP_013130271.1; NC_014165.1.
DR   STRING; 469371.Tbis_0001; -.
DR   EnsemblBacteria; ADG86738; ADG86738; Tbis_0001.
DR   KEGG; tbi:Tbis_0001; -.
DR   eggNOG; ENOG4105CI4; Bacteria.
DR   eggNOG; COG0593; LUCA.
DR   HOGENOM; HOG000235658; -.
DR   KO; K02313; -.
DR   OMA; REFNPLF; -.
DR   OrthoDB; POG091H02FF; -.
DR   Proteomes; UP000006640; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731922};
KW   Complete proteome {ECO:0000313|Proteomes:UP000006640};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731897};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006640}.
FT   DOMAIN      218    346       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      430    499       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     226    233       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   527 AA;  58362 MW;  C2D1A7261D677545 CRC64;
     MEGVDLDAVW ARALRTLLDE GVSGQQRAFL QMTQPSGLIN DTILLAAPND FAKEVIEVRL
     RPLIAHALAQ ELGRPVRIAV MVDPSAVPDA GVDRPDRQPM TQPGQTGYPQ HRPQTQPGFS
     TGLTTGSPGL ATGGESAARH EAGPYSSSVP RPGGLAGEPR PEPRPEPAHQ RWDSRPSRSS
     SEPARLNAKY TFETFVIGAS NRFAHAAAVA VAEAPAKAYN PLFIYGDSGL GKTHLLHAIG
     HYAQSLYDGA RVRYVSSEEF TNEFINSIRD HKADEFRARY RAVDILLVDD IQFLEGKEQT
     QEEFFHTFNT LHNASKQIVI SSDRAPKQLV TLEDRLRNRF EWGLITDVQP PELETRIAIL
     RKKAVQEGLA APPEVLEYIA SRISTNIREL EGALIRVTAF ASLNRQPVDI ELAEMVLKDL
     ISEESSPEIT ISLIMSTTAE YFGVSIDDLC GSSRSRALVT ARQIAMYLAR ELTDLSLPKI
     GQQFGGRDHT TVMHAERKIR SLMAERRSMY NQVNELTTRI KQRARNG
//
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