ID D6Y2V9_THEBD Unreviewed; 743 AA.
AC D6Y2V9;
DT 10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT 10-AUG-2010, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=Drug exporter of the RND superfamily-like protein {ECO:0000313|EMBL:ADG86920.1};
GN OrderedLocusNames=Tbis_0188 {ECO:0000313|EMBL:ADG86920.1};
OS Thermobispora bispora (strain ATCC 19993 / DSM 43833 / CBS 139.67 / JCM
OS 10125 / KCTC 9307 / NBRC 14880 / R51).
OC Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC Streptosporangiaceae; Thermobispora.
OX NCBI_TaxID=469371 {ECO:0000313|EMBL:ADG86920.1, ECO:0000313|Proteomes:UP000006640};
RN [1] {ECO:0000313|EMBL:ADG86920.1, ECO:0000313|Proteomes:UP000006640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 19993 / DSM 43833 / CBS 139.67 / JCM 10125 / KCTC 9307 /
RC NBRC 14880 / R51 {ECO:0000313|Proteomes:UP000006640};
RG US DOE Joint Genome Institute (JGI-PGF);
RA Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA Bruce D., Goodwin L., Pitluck S., Kyrpides N., Mavromatis K., Ivanova N.,
RA Mikhailova N., Chertkov O., Brettin T., Detter J.C., Han C., Larimer F.,
RA Land M., Hauser L., Markowitz V., Cheng J.-F., Hugenholtz P., Woyke T.,
RA Wu D., Jando M., Schneider S., Klenk H.-P., Eisen J.A.;
RT "The complete genome of Thermobispora bispora DSM 43833.";
RL Submitted (JAN-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; CP001874; ADG86920.1; -; Genomic_DNA.
DR RefSeq; WP_013130453.1; NC_014165.1.
DR AlphaFoldDB; D6Y2V9; -.
DR STRING; 469371.Tbis_0188; -.
DR KEGG; tbi:Tbis_0188; -.
DR eggNOG; COG2409; Bacteria.
DR HOGENOM; CLU_005108_5_2_11; -.
DR OrthoDB; 7051771at2; -.
DR Proteomes; UP000006640; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR004869; MMPL_dom.
DR InterPro; IPR000731; SSD.
DR PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR PANTHER; PTHR33406:SF2; MEMBRANE PROTEIN SCO6666-RELATED; 1.
DR Pfam; PF03176; MMPL; 2.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR PROSITE; PS50156; SSD; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000006640};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 20..40
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 194..227
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 239..258
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 279..304
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 316..339
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 389..408
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 541..559
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 571..589
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 609..630
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 651..673
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 685..710
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 209..338
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
SQ SEQUENCE 743 AA; 79779 MW; 71754E47B7FC8C4F CRC64;
MRQRNFAAAI GGWSARHRWW ALLIWVVFVA VATVAGNAVG TAEMERWEAL NGDSREALRI
LDEAGFPRVA GEFVLVQARQ GSLTADDPRF RQAVLDVKSA VEATGEVQNV RTPYDPEPSP
VTQDRRTALI RFEMKGDAAT AKDRVRPVLD AVAGVQRAHP ELRIEQAGDA SSDLLINEAI
DRDFMRAEQL SIPITVGILL AAFGALLAAL VPVALAMTAI FAATGLLAFT SQLLHVHSLT
ANLMLCIGLA VGVDYSLFYI MRQREERAKG RDPRRAIEIA AATSGRAVLI SGITVMVAMA
GMFLTGSGIF MGFAEGTILV VFTAVLGSLT VLPALLSLIG DKIDSRLIHG TVRAATGGRI
TWRRVLGVRG GESRLWSAIL KPVLRRPGLS VVVAGGLLAA LAVPALGLKT GPESIDDLQG
DYSIAETFKR INSAFPSGTD PAVVVVKAAD VTAPEFTARI EEFKRRALAT GQTNEPINVV
VNPDKTVAMI TIGIKGTGTD AVSEQAIRTL REQVIPETLP GAHVTGMTAN GMDFGEQLRR
SLPLVFGFVL LFAFLLLLVS FRSVVIAITS IALNLLSVGA AYGVLVLVFQ KGYGESLLGF
RSTGEITDWV PLFLFVILFG LSMDYHVFIL SRIREAYDSG MRTEDAVVTG ITSTAAVVTS
AAIIMVAVFA TFATLSLLQF KELGFGLAVA VLIDATIVRA VLLPAAMRLL GDRNWYLPRW
LGWLPTLSHG DEQEKERTPA LVG
//
