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Database: UniProt
Entry: D6YWK2_WADCW
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Original site: D6YWK2_WADCW 
ID   D6YWK2_WADCW            Unreviewed;       457 AA.
AC   D6YWK2;
DT   10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT   10-AUG-2010, sequence version 1.
DT   20-DEC-2017, entry version 56.
DE   RecName: Full=Exodeoxyribonuclease 7 large subunit {ECO:0000256|HAMAP-Rule:MF_00378};
DE            EC=3.1.11.6 {ECO:0000256|HAMAP-Rule:MF_00378};
DE   AltName: Full=Exodeoxyribonuclease VII large subunit {ECO:0000256|HAMAP-Rule:MF_00378};
DE            Short=Exonuclease VII large subunit {ECO:0000256|HAMAP-Rule:MF_00378};
GN   Name=xseA {ECO:0000256|HAMAP-Rule:MF_00378,
GN   ECO:0000313|EMBL:ADI38513.1};
GN   OrderedLocusNames=wcw_1156 {ECO:0000313|EMBL:ADI38513.1};
OS   Waddlia chondrophila (strain ATCC VR-1470 / WSU 86-1044).
OC   Bacteria; Chlamydiae; Parachlamydiales; Waddliaceae; Waddlia.
OX   NCBI_TaxID=716544 {ECO:0000313|EMBL:ADI38513.1, ECO:0000313|Proteomes:UP000001505};
RN   [1] {ECO:0000313|EMBL:ADI38513.1, ECO:0000313|Proteomes:UP000001505}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC VR-1470 / WSU 86-1044 {ECO:0000313|Proteomes:UP000001505};
RX   PubMed=20531937; DOI=10.1371/journal.pone.0010890;
RA   Bertelli C., Collyn F., Croxatto A., Ruckert C., Polkinghorne A.,
RA   Kebbi-Beghdadi C., Goesmann A., Vaughan L., Greub G.;
RT   "The Waddlia genome: a window into chlamydial biology.";
RL   PLoS ONE 5:E10890-E10890(2010).
CC   -!- FUNCTION: Bidirectionally degrades single-stranded DNA into large
CC       acid-insoluble oligonucleotides, which are then degraded further
CC       into small acid-soluble oligonucleotides. {ECO:0000256|HAMAP-
CC       Rule:MF_00378, ECO:0000256|SAAS:SAAS00723532}.
CC   -!- CATALYTIC ACTIVITY: Exonucleolytic cleavage in either 5'- to
CC       3'- or 3'- to 5'-direction to yield nucleoside 5'-phosphates.
CC       {ECO:0000256|HAMAP-Rule:MF_00378, ECO:0000256|RuleBase:RU004355,
CC       ECO:0000256|SAAS:SAAS00723505}.
CC   -!- SUBUNIT: Heterooligomer composed of large and small subunits.
CC       {ECO:0000256|HAMAP-Rule:MF_00378}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00378,
CC       ECO:0000256|RuleBase:RU004355, ECO:0000256|SAAS:SAAS00723552}.
CC   -!- SIMILARITY: Belongs to the XseA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00378, ECO:0000256|RuleBase:RU004355,
CC       ECO:0000256|SAAS:SAAS00723548}.
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DR   EMBL; CP001928; ADI38513.1; -; Genomic_DNA.
DR   RefSeq; WP_013182226.1; NZ_LVEB01000017.1.
DR   STRING; 716544.wcw_1156; -.
DR   EnsemblBacteria; ADI38513; ADI38513; wcw_1156.
DR   KEGG; wch:wcw_1156; -.
DR   eggNOG; ENOG4105DVS; Bacteria.
DR   eggNOG; COG1570; LUCA.
DR   HOGENOM; HOG000229265; -.
DR   KO; K03601; -.
DR   OMA; NARRRWP; -.
DR   OrthoDB; POG091H02EK; -.
DR   Proteomes; UP000001505; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009318; C:exodeoxyribonuclease VII complex; IEA:InterPro.
DR   GO; GO:0008855; F:exodeoxyribonuclease VII activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0006308; P:DNA catabolic process; IEA:UniProtKB-UniRule.
DR   CDD; cd04489; ExoVII_LU_OBF; 1.
DR   Gene3D; 3.40.50.261; -; 1.
DR   HAMAP; MF_00378; Exonuc_7_L; 1.
DR   InterPro; IPR003753; Exonuc_VII_L.
DR   InterPro; IPR020579; Exonuc_VII_lsu_C.
DR   InterPro; IPR025824; OB-fold_nuc-bd_dom.
DR   InterPro; IPR016102; Succinyl-CoA_synth-like.
DR   PANTHER; PTHR30008; PTHR30008; 1.
DR   Pfam; PF02601; Exonuc_VII_L; 1.
DR   Pfam; PF13742; tRNA_anti_2; 1.
DR   TIGRFAMs; TIGR00237; xseA; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001505};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00378,
KW   ECO:0000256|SAAS:SAAS00723549};
KW   Exonuclease {ECO:0000256|HAMAP-Rule:MF_00378,
KW   ECO:0000256|RuleBase:RU004355, ECO:0000256|SAAS:SAAS00723511};
KW   Hydrolase {ECO:0000256|HAMAP-Rule:MF_00378,
KW   ECO:0000256|RuleBase:RU004355, ECO:0000256|SAAS:SAAS00723558,
KW   ECO:0000313|EMBL:ADI38513.1};
KW   Nuclease {ECO:0000256|HAMAP-Rule:MF_00378,
KW   ECO:0000256|RuleBase:RU004355, ECO:0000256|SAAS:SAAS00723518};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001505}.
FT   DOMAIN       12    104       tRNA_anti_2. {ECO:0000259|Pfam:PF13742}.
FT   DOMAIN      128    442       Exonuc_VII_L. {ECO:0000259|Pfam:PF02601}.
FT   COILED      273    293       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   457 AA;  50876 MW;  AB3267B64BAA8166 CRC64;
     MTSKLSQDLP ILTVSQLTNA IKHQLESTFP SIWLQGEVSN FKKHSSGHLY FSLKDGQAQI
     SAVMFRGHVQ SLKMIPKDGD QVVVYGGINV FAPSGKYQIN VQTLRLAGVG ELLLKLEELK
     KELHQRGWFS QEHKKPLPKF PKKIGIVTSP TGAAIRDMLN VLNRRHGGYH ILLNPVKVQG
     EGAASEIARA IEQFNEHKMV DVIIVGRGGG SIEDLWAFNE EIVAKAIFES SIPIIGAVGH
     ETDHCIAEYV ADVRAPTPSA AAEIVGGEKA QQIEFLIQAQ KQLTQNLRRQ LRQWSTRLQQ
     ILKTPLMSSP YALIGPWLQS MDDARLNADR AIKHVIRNQK VVLKSRFQML QSLKPTAKIL
     HFRQRLESLT KQCDLNISGL LKQREERLKR VASALQSIDP KNLLKKGYSI LFSKKTGSVI
     TTIKAVNKGD TVKVLLSDGE ALAHISHSIS SNQSKRL
//
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