ID D7AYX8_NOCDD Unreviewed; 1363 AA.
AC D7AYX8;
DT 10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT 10-AUG-2010, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN OrderedLocusNames=Ndas_2727 {ECO:0000313|EMBL:ADH68140.1};
OS Nocardiopsis dassonvillei (strain ATCC 23218 / DSM 43111 / CIP 107115 / JCM
OS 7437 / KCTC 9190 / NBRC 14626 / NCTC 10488 / NRRL B-5397 / IMRU 509)
OS (Actinomadura dassonvillei).
OC Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC Nocardiopsaceae; Nocardiopsis.
OX NCBI_TaxID=446468 {ECO:0000313|EMBL:ADH68140.1, ECO:0000313|Proteomes:UP000002219};
RN [1] {ECO:0000313|EMBL:ADH68140.1, ECO:0000313|Proteomes:UP000002219}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 23218 / DSM 43111 / CIP 107115 / JCM 7437 / KCTC 9190 /
RC NBRC 14626 / NCTC 10488 / NRRL B-5397 / IMRU 509
RC {ECO:0000313|Proteomes:UP000002219};
RX PubMed=21304737; DOI=10.4056/sigs.1363462;
RA Sun H., Lapidus A., Nolan M., Lucas S., Del Rio T.G., Tice H., Cheng J.F.,
RA Tapia R., Han C., Goodwin L., Pitluck S., Pagani I., Ivanova N.,
RA Mavromatis K., Mikhailova N., Pati A., Chen A., Palaniappan K., Land M.,
RA Hauser L., Chang Y.J., Jeffries C.D., Djao O.D., Rohde M., Sikorski J.,
RA Goker M., Woyke T., Bristow J., Eisen J.A., Markowitz V., Hugenholtz P.,
RA Kyrpides N.C., Klenk H.P.;
RT "Complete genome sequence of Nocardiopsis dassonvillei type strain (IMRU
RT 509).";
RL Stand. Genomic Sci. 3:325-336(2010).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
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DR EMBL; CP002040; ADH68140.1; -; Genomic_DNA.
DR RefSeq; WP_013153747.1; NC_014210.1.
DR STRING; 446468.Ndas_2727; -.
DR REBASE; 26264; NdaDORF2727P.
DR KEGG; nda:Ndas_2727; -.
DR eggNOG; COG1002; Bacteria.
DR HOGENOM; CLU_004385_0_0_11; -.
DR OrthoDB; 4280289at2; -.
DR Proteomes; UP000002219; Chromosome 1.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0043412; P:macromolecule modification; IEA:UniProt.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0044238; P:primary metabolic process; IEA:UniProt.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR046816; MmeI_Mtase.
DR InterPro; IPR046820; MmeI_TRD.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR33841; DNA METHYLTRANSFERASE YEEA-RELATED; 1.
DR PANTHER; PTHR33841:SF5; TYPE II METHYLTRANSFERASE M.HINDII; 1.
DR Pfam; PF20473; MmeI_Mtase; 1.
DR Pfam; PF20466; MmeI_TRD; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Reference proteome {ECO:0000313|Proteomes:UP000002219};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 886..984
FT /note="MmeI-like DNA-methyltransferase"
FT /evidence="ECO:0000259|Pfam:PF20473"
FT DOMAIN 1032..1228
FT /note="MmeI-like target recognition"
FT /evidence="ECO:0000259|Pfam:PF20466"
FT REGION 1342..1363
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1342..1357
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1363 AA; 151811 MW; 9CC15EF2C99B0456 CRC64;
MSNPRSRGKH SPADAVRQQH LDWLGLVEVS GPFLTLPVLR EVWSAGLDSL EPEQMRELRR
TSALWRDQTG PGGGDREAGR DAWVRYVLGD LLDWRETLRT DGLEPLAMEV AEHDTAVAPS
FVLTHPDAEP EGEVKADDVR LLGLTCPVDQ SPVQRVKDDS WSATPADRLA QLCRHHGVEL
GLATNGRWWV LVWAPRGGVT TTALFDASLW TDAAERDVLR AFYSLLNRRR FFTVPDEQQL
VPLLNRSLGS QEDVTEALGV QVRQAVELLV AAIGRADTRA RERGERDLSA VSAHDVYRGA
VSVMMRTVFL LFAEERGLLP SDNDLYAGSY SAGGLYEELE ALAREGTEDD LERTTAAWHR
LLALFHAVYH GVDHPKLRMH ALDGSLFNPE TFPWLPLDID DRTVLHMLKA VQYVKVGRGK
SAELRKLSFR ALDVEQIGYV YEGLLAFDGF RAEDLVVGLV GKEGLEAEVQ LRDLEALAAR
HTDVEELAEE LAAEYKDSGI GSARKLAKAL APLSKEERTE AVKQLRGVVP GDEPLVERLL
PFFRILRNDL RGLPMVVRGG ELYVTESALR KNTGTHYTPR ELAEKVVFNA LEPLVYAPGP
LQTADTSKWK LKNSHEILAL KVADIAMGSA AFLVAAARYL GDRLIEAWAK EKDPHAEGYT
PQENDVRSDD DKVVIEARRQ VIEHCLYGVD INPMAVEMAK LSLWLVSMDP KRPFTFLDDR
LASGDSLLGI TSLEQLEYMH MDPKQGRKIH ERGLVDFTRG VRVLIGRAAE SRRKLSKMDG
ATMDGVNRKR SVLGETELET GQARLLADLV VGAALSSVGK SEAIARDQAL KAADLARRLN
TAEPEARITA KKWLDTDRPN GAFERKPLHW PLAFPEVFEN GGFDAVIGNP PFLGGPKIRP
TLGGQYRELI TEVIAKGTRA TNTDLVAYFA LQAHRVVNKE GQAGIIATNT LTQGATRRVG
LDQIIESGVL IRGAIKSESW PSRSAALEYC VAWTTKKSLE KDSIVLADGV ATATITATLD
ASTSKKKPAH KLAKNAKVSF LGHHVNGKGF ILTPQEASYL LSTEDNNSEV VFPYLIGQDI
ADSPTSSPSR WIINFHDWSE EKSKKYKDPF QKVDSLVKPE RLKRNRESHR KYWWRYADYR
RGLESSISSL DRIIAFARVS KTTAPVMVPT GQVFSEQIVV LASDDTAMLA LLSSTSHYWW
AITRASTLET RIRYTPSDVF ETFAMPELTQ ELRDLGDRLD TYRRDVMLSR NTGLTKTYNL
VFDPACNDSD IVELRAIHRA IDEATIRAYG WEDRIEAVSG LDHGFHKVGR ETRYTIGPAA
QREVLDSLLE LNHERYAEEV AQGLHDKKGK RKSAAQEGTL FDV
//
