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Database: UniProt
Entry: D7BSN8_STRBB
LinkDB: D7BSN8_STRBB
Original site: D7BSN8_STRBB 
ID   D7BSN8_STRBB            Unreviewed;      3991 AA.
AC   D7BSN8;
DT   10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT   10-AUG-2010, sequence version 1.
DT   24-JAN-2024, entry version 77.
DE   SubName: Full=Putative type I polyketide synthase {ECO:0000313|EMBL:ADI11535.1};
GN   Name=nanA3 {ECO:0000313|EMBL:ADI11535.1};
GN   OrderedLocusNames=SBI_08417 {ECO:0000313|EMBL:ADI11535.1};
OS   Streptomyces bingchenggensis (strain BCW-1).
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=749414 {ECO:0000313|EMBL:ADI11535.1, ECO:0000313|Proteomes:UP000000377};
RN   [1] {ECO:0000313|EMBL:ADI11535.1, ECO:0000313|Proteomes:UP000000377}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BCW-1 {ECO:0000313|EMBL:ADI11535.1,
RC   ECO:0000313|Proteomes:UP000000377};
RX   PubMed=20581206; DOI=10.1128/JB.00596-10;
RA   Wang X.J., Yan Y.J., Zhang B., An J., Wang J.J., Tian J., Jiang L.,
RA   Chen Y.H., Huang S.X., Yin M., Zhang J., Gao A.L., Liu C.X., Zhu Z.X.,
RA   Xiang W.S.;
RT   "Genome sequence of the milbemycin-producing bacterium Streptomyces
RT   bingchenggensis.";
RL   J. Bacteriol. 192:4526-4527(2010).
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DR   EMBL; CP002047; ADI11535.1; -; Genomic_DNA.
DR   RefSeq; WP_014180985.1; NC_016582.1.
DR   STRING; 749414.SBI_08417; -.
DR   KEGG; sbh:SBI_08417; -.
DR   PATRIC; fig|749414.3.peg.8662; -.
DR   eggNOG; COG0604; Bacteria.
DR   eggNOG; COG1028; Bacteria.
DR   eggNOG; COG3321; Bacteria.
DR   HOGENOM; CLU_000022_35_8_11; -.
DR   Proteomes; UP000000377; Chromosome.
DR   GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR   GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR   GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR   GO; GO:0033068; P:macrolide biosynthetic process; IEA:UniProt.
DR   CDD; cd05195; enoyl_red; 1.
DR   CDD; cd08956; KR_3_FAS_SDR_x; 2.
DR   CDD; cd00833; PKS; 2.
DR   Gene3D; 3.30.70.3290; -; 2.
DR   Gene3D; 3.40.47.10; -; 3.
DR   Gene3D; 3.40.50.11460; -; 1.
DR   Gene3D; 1.10.1200.10; ACP-like; 2.
DR   Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 2.
DR   Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR   Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 2.
DR   InterPro; IPR001227; Ac_transferase_dom_sf.
DR   InterPro; IPR036736; ACP-like_sf.
DR   InterPro; IPR014043; Acyl_transferase.
DR   InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR   InterPro; IPR013154; ADH-like_N.
DR   InterPro; IPR011032; GroES-like_sf.
DR   InterPro; IPR018201; Ketoacyl_synth_AS.
DR   InterPro; IPR014031; Ketoacyl_synth_C.
DR   InterPro; IPR014030; Ketoacyl_synth_N.
DR   InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR032821; PKS_assoc.
DR   InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR   InterPro; IPR042104; PKS_dehydratase_sf.
DR   InterPro; IPR020807; PKS_DH.
DR   InterPro; IPR020843; PKS_ER.
DR   InterPro; IPR013968; PKS_KR.
DR   InterPro; IPR020806; PKS_PP-bd.
DR   InterPro; IPR015083; Polyketide_synth_docking.
DR   InterPro; IPR036299; Polyketide_synth_docking_sf.
DR   InterPro; IPR009081; PP-bd_ACP.
DR   InterPro; IPR006162; Ppantetheine_attach_site.
DR   InterPro; IPR016039; Thiolase-like.
DR   PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR   PANTHER; PTHR43775:SF51; INACTIVE PHENOLPHTHIOCEROL SYNTHESIS POLYKETIDE SYNTHASE TYPE I PKS1-RELATED; 1.
DR   Pfam; PF00698; Acyl_transf_1; 2.
DR   Pfam; PF08240; ADH_N; 1.
DR   Pfam; PF13602; ADH_zinc_N_2; 1.
DR   Pfam; PF08990; Docking; 1.
DR   Pfam; PF16197; KAsynt_C_assoc; 2.
DR   Pfam; PF00109; ketoacyl-synt; 2.
DR   Pfam; PF02801; Ketoacyl-synt_C; 1.
DR   Pfam; PF08659; KR; 2.
DR   Pfam; PF21089; PKS_DH_N; 2.
DR   Pfam; PF00550; PP-binding; 2.
DR   Pfam; PF14765; PS-DH; 2.
DR   SMART; SM00827; PKS_AT; 2.
DR   SMART; SM00826; PKS_DH; 2.
DR   SMART; SM00829; PKS_ER; 1.
DR   SMART; SM00822; PKS_KR; 2.
DR   SMART; SM00825; PKS_KS; 2.
DR   SMART; SM00823; PKS_PP; 2.
DR   SMART; SM01294; PKS_PP_betabranch; 2.
DR   SUPFAM; SSF47336; ACP-like; 2.
DR   SUPFAM; SSF101173; Docking domain B of the erythromycin polyketide synthase (DEBS); 1.
DR   SUPFAM; SSF52151; FabD/lysophospholipase-like; 2.
DR   SUPFAM; SSF50129; GroES-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 5.
DR   SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 2.
DR   SUPFAM; SSF53901; Thiolase-like; 2.
DR   PROSITE; PS50075; CARRIER; 2.
DR   PROSITE; PS00606; KS3_1; 2.
DR   PROSITE; PS52004; KS3_2; 2.
DR   PROSITE; PS00012; PHOSPHOPANTETHEINE; 2.
PE   4: Predicted;
KW   Acyltransferase {ECO:0000256|ARBA:ARBA00023315};
KW   Antibiotic biosynthesis {ECO:0000256|ARBA:ARBA00023194};
KW   Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW   Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000377};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          36..460
FT                   /note="Ketosynthase family 3 (KS3)"
FT                   /evidence="ECO:0000259|PROSITE:PS52004"
FT   DOMAIN          1782..1857
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
FT   DOMAIN          1884..2253
FT                   /note="Ketosynthase family 3 (KS3)"
FT                   /evidence="ECO:0000259|PROSITE:PS52004"
FT   DOMAIN          3830..3905
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
FT   REGION          462..484
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          875..894
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1072..1104
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   3991 AA;  414360 MW;  CB01EC27ED2CEE3A CRC64;
     MTTETNEERL VDYLKRVAAD LHDTRARLRE VEDGQREPVA IVAMACRYPG DVASPEALWD
     LVAARRHAMT AFPDNRGWDL ERLFHPDPDH PGTSYAREGG FLHDADLFDP EFFGISPREA
     AVVDPQQRLL LEVAWEALER AGIAPGSLKG APVGVYAGTA LPGFGTPHID RAAEGYLVTG
     NAPSVLSGRV AYTLGLEGPA VTVDTACSSS LVAMHLAAQA LRQGECELAL AGGVTVMTTP
     YVFTEFARQR GLAADSRCKA FSEGADGTAF AEGAGLLVLE RLSDAQRNGH QVLAVMRGSA
     INQDGASNGL TAPNGLAQQR VIRQALAGAR LSPADVDAVE AHGTGTTLGD PIEAQALLAT
     YGQERPEGRP LWLGAIKPNL GHTQGAAGVA GVIKMVMALR NASLPALLHA DRPTSVVDWD
     GGAVRLRAEP VAWPAGDRRR RAGVSSFGIS GTNAHLILEE APPQPVPEDT ADTADTADTP
     QRPEGTVVPW VVSARGAASL RTQAAALAEH MAAHPGTLVD AIGWSLATTR SPLDHRAVVL
     GADREELSAR LADLAEGRTH PDVTRASAPA RLGGSAFLFT GQGSQRPGMG AQLYRAYPAF
     AAAFDEACAA LDPHLGRSLR ELVFAPADAD GDGDADRASA LDATEVTQAA LFAVEVALYR
     LVESFGVVPG YLAGHSVGEL VAAHIAGVLS LPDAARLVAA RGRLMQALPE GGAMVALEAA
     EEEVAPLLAG RADQVALAAV NAPTSVVVSG DEEAVEEIAR TIRERGHRTR RLRVGHAFHS
     PRIDPMLEEF RQVAASLTYS QPRIAVVSNV TGALAGAEQL CDPDYWVRHA RQPVRFRDGI
     AALRAEGVTR FLELGPDAVL TAMARDCLTS EAAPEVAAGE SAQDAGTSSG PGAPVLATVL
     RKGRDEPRTL LTALAQLHVD GESVDFSAAF PPATQATDLP TYRFDRRRYW RGAPPRPPAP
     QAEADVRAAG LEASDHPLLR AALEPADGGL LLTGRLSLRG QPWLADHAIV DAVPLPGTLF
     VELALQAGER VGCDLIDDLT LEAPLLLPPV GAVDLQVAVG APGAAGRRAV TVYSRPSGGG
     SEGSEDPGVA DEPGDGPSGA YGPWRRHATA TLSATATGAA TGVPEPAAPP AQWPPAGAEA
     IDVAGLYERL AAEGYRYGPA FTGLRTAWRV GEEMFAEVGL APGQRGDGGA YAIHPALLDA
     ALHPIGALFT GVDQAGGAPG TVRLPFSFGG VRLLARGASR LRVRITPTGP DTVTMRLSDD
     TGAEVVAVDS LTLRAVSAQR WRSGAVPADR PLYRLGWDAF ALPAAATTAP DRWAVPAADD
     TNATDAATAS LPAEHVARHP DLAALSASVA AGAPAPDLVV MACLGAPYDT SDDGDEPPSR
     VRTATHRVLA RLREWLTDDA LATSRLVVLT AGAVAADPAD APPDLAGAAV LGLLRAAQAE
     HPGRIVLVDT DGTSASRDAL AAAVAAAVAA GEWQLALRDG RALVPRLVLA HPDPDAAPVL
     LDPDGTVLVT GGTGSLGRLL ARHLVENHGA RHLLLVSRSG AAAEGIEAFA AGLAADVRIE
     SCDTADPEAL AALLATVPGE HPLTAVVHTA GVLDDGVVTS LTPEQLDAVL APKVDAAWQL
     HRLTRGADLA SFVLFSSAAS VLGSGGQGNY GAANAFLNAL AEHIRAAGGP ATSLAWGLWG
     VDEGMTEHLA TADRARMARS GTAAMSGEAG LARFDAALAT ALPVLVPARF DLAVLREQAA
     TGALPPLLRR LVRLPVRTAA AVAASPSWAG RLAGLPETEQ DRVIGELIRD RIAAVLAHPE
     PETLELGRTF AQLGLDSLTA LELRNAIHEA TGVRLPATAI FDYPTPETLV SHLRTELLGA
     TAATAATTPL SPGAGAPARS GSADDPVVIV GMACHYPGDV HSPDELWRLV ADGVDAIGPF
     PEDRGWDVAG LYDPDPERTG KSYTREGGFL PEAALFDAEF FGISPREALA TDPQQRLLLE
     TAWQAFEHAR IDPAALRGSR TAVVTGIMYD DYGARFLGRI PEGYEGQIMT GSTPSVASGR
     VAYTFGLEGP TLTVDTACSS SLVAMHLAAQ ALRQGECDLA LAGGVTVMAT PNTFIEFSRQ
     RGLAPDGRRR PSNVIGQALA VAGVDPAGVD VVEAHGTGTT LGDPIEAQAL LATYGRNRPA
     GQPLWLGSIK SNIGHTQAAA GAAGIIKMVM ALRHGRLPAT LHVDEPSPHV DWASGSVRLL
     TEATDWPEAD RPRRAAVSSF GISGTNAHII LEQAPDQPEP LPEQSASAAA GGIVPFVLSA
     RTAEALRAQA ANLAARLPSA EVAEVGWSLA TTRSAFEHRA VIVAEDRDAL LAGLEKLAAD
     EPDPAVVAGA ATTAAAGPVF VFPGQGSQWR GMGVELLDTS PVFAARIAEC ERALAPYVDW
     SLTAVLRGAD TTTDPHRVDV VQPTLWAVMV SLAALWQHLG IAPAAVIGHS QGEIAAACVA
     GALTLDDAAK VVALRSQALR ALAGHGTMAS LTLGADDTAG LLEELGEQAD DVTLAAANGP
     ATTVISGAVE QIATVLAAAE ARGARTRTID VDYASHGPHV DRIREDIVSA LSGLAPTVSE
     VAFYSTVTAE RLDTVGLDAD YWFTNLRRPV RFADTLATLL AHGHRHFIEV SPHPVLIPGM
     QDGFEAADAA ATAVPTLRRD QGGPHQLAQA VARAYTAGLA IDWAPWYPAE PHTTDLPTYP
     FQRRRYWLGM DGGPGDLRSA GLISVAHAQL GAAVELADGG LVMTGRLPAA GSGGWLDDHV
     VADTPLVPGT ALVEWVLRAA DEAGCGGIEE LALHVPMTLP ASGGLRIQVV AYAPDGDGRR
     EVRVHSRPDA EDGWSPWTCH ATGHLSPTAP TAPGAADPAQ AGVWPPRDAE QIDVADFYGR
     AEAIGYGYGP AFRGLTAAWR QGDDLLAEVV LPEAAHEGSD GFALHPALLD AALHPLALDG
     QGEDGQMRLP FAWSGVSLWA TGARAVRVRM SPLEHGFRLV VADAAGRPVL SAESVVVRPT
     SAGQLRDAGA RRVDGLYEVA WVPLPPSSDT EAETETRGVE GWALLDGGPL PFDPSKAGSL
     PRYADIDALL TAAALPSTVL VGVSGAVGAA GAEGDEDSAE VALAVTTGVL APARRWLETP
     ELADARLVLV TRGAVAAAET DDGPDPAAAA VWGLLRSAQA ENPGRFLLCD IDDGAGPDDV
     LGAVTRAVAL DEPQVAVRDG RVLTPRLECA GAAGLAPPPG APAWRLAADD TGTIDSVSVV
     ACPEVLEPLA PGQVRIAVRA AGINFRDVLI VLGMYPDEGV FRGSEGAGVV LDVADDVTSV
     AVGDRVFGLF EGAFGPVAVA DARAVVPIPP GWTDQQAAAV PTTFLTAWYG LVDLAGLKAG
     ESVLIHAATG GVGTAAVQIA RHLGAEVYAT ASPGKHAVLE AMGIDEAHRA SSRDLDFEDA
     FRTAAGGRGF DVVLNSLAGE YTDASLRLLT GGGRFIEMGK TDKRDAEQIA DTYPGVRYRF
     YDLVPDAGLN RVAEMLTTLA GHFAQGVLAP PPVRAWPLTE ARQALRQMSQ ARHTGKYVLD
     MPRTLGPDGT VLITGGTGTL GALVAEHLVT THHITHLHLL SRRGPDAPGA AELTARLTEL
     GATVRITATD TADPQALRQA LDTVDRDHPL TGVIHAAGAL DDAVLTAQTP ERLASVWAAK
     ATAAANLHRA TKDLPLAMFV IFSSAAGTLG TPGQANYAAA NAYCDALAVR RRQAGLPATS
     IAWGLWAATS AMTGHLADAD LARMSRTGFT PLATPMALAL FDAAGRHGGA TPLALDLDPR
     TLGAQPSDAV PAVLRTVAAA GAPVRRTAAV AQSTDWAGRL AALSAAERHR ELVNLVRTHA
     ATVLGHSDPA ALRADTSFKE LGFDSLTAVE LRNRLSAATG LRLPAALVFD YPDAETMARF
     LDQKLAPADR TEAAAVDHLA PVLNDLARLE STLGSHDVDG KARETIAGRL HALLSRLEGS
     TASAADIDGE ALESASDDEM FALIDQQLGS S
//
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