ID D7C7W4_STRBB Unreviewed; 511 AA.
AC D7C7W4;
DT 10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT 10-AUG-2010, sequence version 1.
DT 27-MAR-2024, entry version 75.
DE SubName: Full=Transcriptional regulator, GntR family with aminotransferase domain protein {ECO:0000313|EMBL:ADI04125.1};
GN OrderedLocusNames=SBI_01004 {ECO:0000313|EMBL:ADI04125.1};
OS Streptomyces bingchenggensis (strain BCW-1).
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=749414 {ECO:0000313|EMBL:ADI04125.1, ECO:0000313|Proteomes:UP000000377};
RN [1] {ECO:0000313|EMBL:ADI04125.1, ECO:0000313|Proteomes:UP000000377}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BCW-1 {ECO:0000313|EMBL:ADI04125.1,
RC ECO:0000313|Proteomes:UP000000377};
RX PubMed=20581206; DOI=10.1128/JB.00596-10;
RA Wang X.J., Yan Y.J., Zhang B., An J., Wang J.J., Tian J., Jiang L.,
RA Chen Y.H., Huang S.X., Yin M., Zhang J., Gao A.L., Liu C.X., Zhu Z.X.,
RA Xiang W.S.;
RT "Genome sequence of the milbemycin-producing bacterium Streptomyces
RT bingchenggensis.";
RL J. Bacteriol. 192:4526-4527(2010).
CC -!- SIMILARITY: In the C-terminal section; belongs to the class-I
CC pyridoxal-phosphate-dependent aminotransferase family.
CC {ECO:0000256|ARBA:ARBA00005384}.
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DR EMBL; CP002047; ADI04125.1; -; Genomic_DNA.
DR RefSeq; WP_014173604.1; NC_016582.1.
DR AlphaFoldDB; D7C7W4; -.
DR STRING; 749414.SBI_01004; -.
DR KEGG; sbh:SBI_01004; -.
DR PATRIC; fig|749414.3.peg.1026; -.
DR eggNOG; COG1167; Bacteria.
DR HOGENOM; CLU_017584_0_1_11; -.
DR Proteomes; UP000000377; Chromosome.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR GO; GO:0008483; F:transaminase activity; IEA:UniProtKB-KW.
DR GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR CDD; cd00609; AAT_like; 1.
DR CDD; cd07377; WHTH_GntR; 1.
DR Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR004839; Aminotransferase_I/II.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR InterPro; IPR000524; Tscrpt_reg_HTH_GntR.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR46577; HTH-TYPE TRANSCRIPTIONAL REGULATORY PROTEIN GABR; 1.
DR PANTHER; PTHR46577:SF1; HTH-TYPE TRANSCRIPTIONAL REGULATORY PROTEIN GABR; 1.
DR Pfam; PF00155; Aminotran_1_2; 1.
DR Pfam; PF00392; GntR; 1.
DR SMART; SM00345; HTH_GNTR; 1.
DR SUPFAM; SSF53383; PLP-dependent transferases; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50949; HTH_GNTR; 1.
PE 3: Inferred from homology;
KW Aminotransferase {ECO:0000313|EMBL:ADI04125.1};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898};
KW Reference proteome {ECO:0000313|Proteomes:UP000000377};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Transferase {ECO:0000313|EMBL:ADI04125.1}.
FT DOMAIN 33..101
FT /note="HTH gntR-type"
FT /evidence="ECO:0000259|PROSITE:PS50949"
FT REGION 1..28
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..25
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 511 AA; 53901 MW; A5FB4A3F624F66A4 CRC64;
MNRSNKGPID RSITSGTSGS DFLQLNTEEA PPGGLADWLA RRLRDAIADG RLPIGGRLPA
TRVLAGELRV SRGVVTEAYR RLTEDGHIAG RGRGGTVVVA APVATAPTPH TREPSGGSPS
AGALFAAPPG ADIFDALRMA PARIDLSPGL PDLGSFPRTA WLRAERSVLT GLSAADFGYG
DPRGTPALRL AVANWLARNR GIRADPDDVL VVAGTAQALG LIGQVFRADG IHQVAVEDPG
SLGARQHLRH CALDTPPVPV DSEGVRVDAL RATGAPAVLL TPAHQFPTGV VLGGERRREL
MRWAGEGGLI VEDDYDAEHR YDRPPAPALR SMLAEHVCYA GSVSKLLAPA LRVGWVLAPP
RYRDALVAAK RFADLGNAAL PQLVLAHLME SGRLERHLRQ LRRRHRRRRD AMIGAIRAQL
PGAVVHGAAA GLHLMVTFDG DFPDTDLAAA ALAHGVKTQP LSWHSIRPGR PGLVLGYAAS
TPTAIAEGIA LIGEALRQEL GRGLGRASAT G
//
