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Database: UniProt
Entry: D7C8V2_STRBB
LinkDB: D7C8V2_STRBB
Original site: D7C8V2_STRBB 
ID   D7C8V2_STRBB            Unreviewed;       618 AA.
AC   D7C8V2;
DT   10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT   10-AUG-2010, sequence version 1.
DT   25-OCT-2017, entry version 53.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377,
GN   ECO:0000313|EMBL:ADI08503.1};
GN   OrderedLocusNames=SBI_05383 {ECO:0000313|EMBL:ADI08503.1};
OS   Streptomyces bingchenggensis (strain BCW-1).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=749414 {ECO:0000313|EMBL:ADI08503.1, ECO:0000313|Proteomes:UP000000377};
RN   [1] {ECO:0000313|EMBL:ADI08503.1, ECO:0000313|Proteomes:UP000000377}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BCW-1 {ECO:0000313|EMBL:ADI08503.1,
RC   ECO:0000313|Proteomes:UP000000377};
RX   PubMed=20581206; DOI=10.1128/JB.00596-10;
RA   Wang X.J., Yan Y.J., Zhang B., An J., Wang J.J., Tian J., Jiang L.,
RA   Chen Y.H., Huang S.X., Yin M., Zhang J., Gao A.L., Liu C.X., Zhu Z.X.,
RA   Xiang W.S.;
RT   "Genome sequence of the milbemycin-producing bacterium Streptomyces
RT   bingchenggensis.";
RL   J. Bacteriol. 192:4526-4527(2010).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00735475}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00911680}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
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DR   EMBL; CP002047; ADI08503.1; -; Genomic_DNA.
DR   STRING; 749414.SBI_05383; -.
DR   EnsemblBacteria; ADI08503; ADI08503; SBI_05383.
DR   KEGG; sbh:SBI_05383; -.
DR   PATRIC; fig|749414.3.peg.5559; -.
DR   eggNOG; ENOG4105CI4; Bacteria.
DR   eggNOG; COG0593; LUCA.
DR   HOGENOM; HOG000235658; -.
DR   KO; K02313; -.
DR   OMA; FPERDPY; -.
DR   OrthoDB; POG091H02FF; -.
DR   Proteomes; UP000000377; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747950};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000377};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00911664};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00747996};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00911684};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747895};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000377}.
FT   DOMAIN      311    439       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      525    594       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     319    326       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   618 AA;  68398 MW;  B97D269ED9775E9E CRC64;
     MLERLLGEGA GQGGQGVEAK DEHWIKRCQP LALVADTALL AVPNEFAKGV LEGRLAPIVS
     ETLSRECGRP IRIAITVDDS AAEPMVPQQP QRDTYESRDT RESRDSYENR DSYESRDAYE
     GYDNRDGYGG RDGYGRPAGD ELPTARPAYP GYEQHRPEPG AWPRPRDDYG WQQPRLGGFP
     EGDPYATQRP QPGYDQQLYD QQPHSDYRGP GAERPGPGPG PGSGPGPDRS PYEQSRRELN
     PLDRSRGGPP VLPSQTGAPG PLAAQPAPAP GPGEPTARLN PKYLFDTFVI GASNRFAHAA
     AVAVAEAPAK AYNPLFIYGE SGLGKTHLLH AIGHYARSLY PGTRVRYVSS EEFTNEFINS
     IRDGKADAFR KRYRDMDILL VDDIQFLASK ESTQEEFFHT FNTLHNANKQ IVLSSDRPPK
     QLVTLEDRLR NRFEWGLITD VQPPELETRI AILRKKAVQE QLNAPPEVLE FIASRISRNI
     RELEGALIRV TAFASLNRQP VDLGLTEIVL KDLIPGGEDA APEITATAIM AATADYFGHT
     VDDLCGASRS RVLVTARQIA MYLCRELTDL SLPKIGAQFG GRDHTTVMHA DRKIRALMAE
     RRSIYNQVTE LTNRIKNG
//
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