ID D7E988_METEZ Unreviewed; 677 AA.
AC D7E988;
DT 10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT 10-AUG-2010, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN OrderedLocusNames=Metev_1155 {ECO:0000313|EMBL:ADI74036.1};
OS Methanohalobium evestigatum (strain ATCC BAA-1072 / DSM 3721 / NBRC 107634
OS / OCM 161 / Z-7303).
OC Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC Methanosarcinales; Methanosarcinaceae; Methanohalobium.
OX NCBI_TaxID=644295 {ECO:0000313|EMBL:ADI74036.1, ECO:0000313|Proteomes:UP000000391};
RN [1] {ECO:0000313|EMBL:ADI74036.1, ECO:0000313|Proteomes:UP000000391}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-1072 / DSM 3721 / NBRC 107634 / OCM 161 / Z-7303
RC {ECO:0000313|Proteomes:UP000000391};
RG US DOE Joint Genome Institute;
RA Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L.,
RA Pitluck S., Saunders E., Detter J.C., Han C., Tapia R., Land M., Hauser L.,
RA Kyrpides N., Mikhailova N., Sieprawska-Lupa M., Whitman W.B., Anderson I.,
RA Woyke T.;
RT "Complete sequence chromosome of Methanohalobium evestigatum Z-7303.";
RL Submitted (JUN-2010) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; CP002069; ADI74036.1; -; Genomic_DNA.
DR RefSeq; WP_013194603.1; NC_014253.1.
DR AlphaFoldDB; D7E988; -.
DR STRING; 644295.Metev_1155; -.
DR GeneID; 9346788; -.
DR KEGG; mev:Metev_1155; -.
DR HOGENOM; CLU_000445_114_71_2; -.
DR OrthoDB; 342253at2157; -.
DR Proteomes; UP000000391; Chromosome.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR CDD; cd00082; HisKA; 1.
DR CDD; cd00130; PAS; 1.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 3.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR001610; PAC.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR000700; PAS-assoc_C.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013656; PAS_4.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR NCBIfam; TIGR00229; sensory_box; 3.
DR PANTHER; PTHR43711:SF32; DRUG SENSORY PROTEIN A; 1.
DR PANTHER; PTHR43711; TWO-COMPONENT HISTIDINE KINASE; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF00512; HisKA; 1.
DR Pfam; PF08448; PAS_4; 2.
DR Pfam; PF13426; PAS_9; 1.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00388; HisKA; 1.
DR SMART; SM00086; PAC; 3.
DR SMART; SM00091; PAS; 3.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 3.
DR PROSITE; PS50109; HIS_KIN; 1.
DR PROSITE; PS50113; PAC; 3.
DR PROSITE; PS50112; PAS; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils}; Kinase {ECO:0000313|EMBL:ADI74036.1};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000000391};
KW Transferase {ECO:0000313|EMBL:ADI74036.1}.
FT DOMAIN 110..162
FT /note="PAC"
FT /evidence="ECO:0000259|PROSITE:PS50113"
FT DOMAIN 181..252
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 252..308
FT /note="PAC"
FT /evidence="ECO:0000259|PROSITE:PS50113"
FT DOMAIN 382..434
FT /note="PAC"
FT /evidence="ECO:0000259|PROSITE:PS50113"
FT DOMAIN 459..677
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
FT COILED 2..36
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 425..459
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 677 AA; 78014 MW; 16D5CCA740B33B2A CRC64;
MEKDDEKSKN QLLQEIKELR NQNSDLQKRL TEFHSNDNQV STLISDDIID FIPDILGIQD
TNHNIIKYNK AGYSFFNLKP EEVAGKKCYE IIGRNKPCKI CATSKVYKSK KPEHVVKYIE
EMDIWFDVRA YPIFDNNGNL TNVMEHLRDI TQEKKLENKI KDQRNNLEKI VYERTKQLEI
ERDKAQKYLD ISGAIIIVLD NNQRIELINN KGCEVLGYDK TELIGKNMYE NFVPREYMDK
VNNISNNLIQ GHEDNNNFIN PIIGKNGEER IISWYNSVLK DDNGSIIGTL SSGIDVTELI
NLKNSLQESK NQYKQLFEES PVGLLKCKSN GKIVDVNKRI LEILNSPSKE ETLKFNLLES
PHIKNSGFDE ELRKAFSNNR IVKNERKYIS FWGRKRWIYY KIVPLGDEEG NVNESIIALD
DITQRKETET QLLKYYDDLQ KANRELKSLS EMKNRFISNV SHELRTPITN IKGYSNLLNN
KKLGELNDKQ SKAVSVISQS CERLRWLIDT LIHINILESD NGIQHTQKIS LSSLLNNVVS
ENSVYFFDKG LNLTTNIDSN LPLVDANPEY LEQVFVHILD NACKFTPSGG KVDVHAFDDG
NLHIIVSDNG IGIDEESANN IFDLFYQKDD SSKRRYSGTG AGMYFCKKII EKHHGNIWVE
SKIKEGTDVH IILPKIS
//
