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Database: UniProt
Entry: D7FF03_HELP3
LinkDB: D7FF03_HELP3
Original site: D7FF03_HELP3 
ID   D7FF03_HELP3            Unreviewed;       307 AA.
AC   D7FF03;
DT   10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT   10-AUG-2010, sequence version 1.
DT   24-JAN-2024, entry version 63.
DE   RecName: Full=Aspartate carbamoyltransferase {ECO:0000256|HAMAP-Rule:MF_00001};
DE            EC=2.1.3.2 {ECO:0000256|HAMAP-Rule:MF_00001};
DE   AltName: Full=Aspartate transcarbamylase {ECO:0000256|HAMAP-Rule:MF_00001};
DE            Short=ATCase {ECO:0000256|HAMAP-Rule:MF_00001};
GN   Name=pyrB {ECO:0000256|HAMAP-Rule:MF_00001,
GN   ECO:0000313|EMBL:CBI66760.1};
GN   OrderedLocusNames=HPB8_1203 {ECO:0000313|EMBL:CBI66760.1};
OS   Helicobacter pylori (strain B8).
OC   Bacteria; Campylobacterota; Epsilonproteobacteria; Campylobacterales;
OC   Helicobacteraceae; Helicobacter.
OX   NCBI_TaxID=693745 {ECO:0000313|EMBL:CBI66760.1, ECO:0000313|Proteomes:UP000007091};
RN   [1] {ECO:0000313|EMBL:CBI66760.1, ECO:0000313|Proteomes:UP000007091}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=B8 {ECO:0000313|EMBL:CBI66760.1,
RC   ECO:0000313|Proteomes:UP000007091};
RX   PubMed=20507619; DOI=10.1186/1471-2164-11-335;
RA   Farnbacher M., Jahns T., Willrodt D., Daniel R., Haas R., Goesmann A.,
RA   Kurtz S., Rieder G.;
RT   "Sequencing, annotation, and comparative genome analysis of the gerbil-
RT   adapted Helicobacter pylori strain B8.";
RL   BMC Genomics 11:335-335(2010).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=carbamoyl phosphate + L-aspartate = H(+) + N-carbamoyl-L-
CC         aspartate + phosphate; Xref=Rhea:RHEA:20013, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:29991, ChEBI:CHEBI:32814, ChEBI:CHEBI:43474,
CC         ChEBI:CHEBI:58228; EC=2.1.3.2;
CC         Evidence={ECO:0000256|ARBA:ARBA00001363, ECO:0000256|HAMAP-
CC         Rule:MF_00001};
CC   -!- PATHWAY: Pyrimidine metabolism; UMP biosynthesis via de novo pathway;
CC       (S)-dihydroorotate from bicarbonate: step 2/3.
CC       {ECO:0000256|ARBA:ARBA00004852, ECO:0000256|HAMAP-Rule:MF_00001}.
CC   -!- SIMILARITY: Belongs to the aspartate/ornithine carbamoyltransferase
CC       superfamily. ATCase family. {ECO:0000256|HAMAP-Rule:MF_00001}.
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DR   EMBL; FN598874; CBI66760.1; -; Genomic_DNA.
DR   RefSeq; WP_001124635.1; NC_014256.1.
DR   AlphaFoldDB; D7FF03; -.
DR   KEGG; hpl:HPB8_1203; -.
DR   HOGENOM; CLU_043846_2_0_7; -.
DR   OMA; FPTEREY; -.
DR   UniPathway; UPA00070; UER00116.
DR   Proteomes; UP000007091; Chromosome.
DR   GO; GO:0016597; F:amino acid binding; IEA:InterPro.
DR   GO; GO:0004070; F:aspartate carbamoyltransferase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006207; P:'de novo' pyrimidine nucleobase biosynthetic process; IEA:InterPro.
DR   GO; GO:0044205; P:'de novo' UMP biosynthetic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0006520; P:amino acid metabolic process; IEA:InterPro.
DR   Gene3D; 3.40.50.1370; Aspartate/ornithine carbamoyltransferase; 2.
DR   HAMAP; MF_00001; Asp_carb_tr; 1.
DR   InterPro; IPR006132; Asp/Orn_carbamoyltranf_P-bd.
DR   InterPro; IPR006130; Asp/Orn_carbamoylTrfase.
DR   InterPro; IPR036901; Asp/Orn_carbamoylTrfase_sf.
DR   InterPro; IPR002082; Asp_carbamoyltransf.
DR   InterPro; IPR006131; Asp_carbamoyltransf_Asp/Orn-bd.
DR   NCBIfam; TIGR00670; asp_carb_tr; 1.
DR   PANTHER; PTHR45753:SF6; ASPARTATE CARBAMOYLTRANSFERASE; 1.
DR   PANTHER; PTHR45753; ORNITHINE CARBAMOYLTRANSFERASE, MITOCHONDRIAL; 1.
DR   Pfam; PF00185; OTCace; 1.
DR   Pfam; PF02729; OTCace_N; 1.
DR   PRINTS; PR00100; AOTCASE.
DR   PRINTS; PR00101; ATCASE.
DR   SUPFAM; SSF53671; Aspartate/ornithine carbamoyltransferase; 1.
DR   PROSITE; PS00097; CARBAMOYLTRANSFERASE; 1.
PE   3: Inferred from homology;
KW   Pyrimidine biosynthesis {ECO:0000256|ARBA:ARBA00022975, ECO:0000256|HAMAP-
KW   Rule:MF_00001};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|HAMAP-
KW   Rule:MF_00001}.
FT   DOMAIN          6..149
FT                   /note="Aspartate/ornithine carbamoyltransferase carbamoyl-P
FT                   binding"
FT                   /evidence="ECO:0000259|Pfam:PF02729"
FT   DOMAIN          159..303
FT                   /note="Aspartate/ornithine carbamoyltransferase Asp/Orn-
FT                   binding"
FT                   /evidence="ECO:0000259|Pfam:PF00185"
SQ   SEQUENCE   307 AA;  34120 MW;  637FABAE28D82908 CRC64;
     MPKKCRHLLQ TSDLSLDEIK LLLNKASVYA NDFNAVSLET KEKMYNKIIV ALFFENSTRT
     VSSFEIASLR LGAKIVKLNM QTSSTSKGET LTDTFKNIHA MQPDAIITRH AFSSAPFKLA
     EFSQCPLINA GSGVSAHPTQ ALLDLLTLYR HFGSLENLKG KKIAFIGDVK NSRVANSNIK
     LLQRLGLEIM LCAPSSMLPS VSLKTTHNIE EAIAFADILM SLRTQTERHN APIFASLKDY
     GNAYCITQQR LKAHAKNKEV IILHPGPVHR DIDIESAVLE DKRSKVLEQV KNGVAMRMAV
     LEFLLLD
//
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