ID D7FJ20_ECTSI Unreviewed; 1606 AA.
AC D7FJ20;
DT 10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT 10-AUG-2010, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=Calmodulin-binding WW domain protein {ECO:0000313|EMBL:CBJ49059.1};
GN ORFNames=Esi_0125_0068 {ECO:0000313|EMBL:CBJ49059.1};
OS Ectocarpus siliculosus (Brown alga) (Conferva siliculosa).
OC Eukaryota; Sar; Stramenopiles; Ochrophyta; PX clade; Phaeophyceae;
OC Ectocarpales; Ectocarpaceae; Ectocarpus.
OX NCBI_TaxID=2880 {ECO:0000313|EMBL:CBJ49059.1, ECO:0000313|Proteomes:UP000002630};
RN [1] {ECO:0000313|EMBL:CBJ49059.1, ECO:0000313|Proteomes:UP000002630}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ec32 / CCAP1310/4 {ECO:0000313|Proteomes:UP000002630};
RX PubMed=20520714; DOI=10.1038/nature09016;
RA Cock J.M., Sterck L., Rouze P., Scornet D., Allen A.E., Amoutzias G.,
RA Anthouard V., Artiguenave F., Aury J.M., Badger J.H., Beszteri B.,
RA Billiau K., Bonnet E., Bothwell J.H., Bowler C., Boyen C., Brownlee C.,
RA Carrano C.J., Charrier B., Cho G.Y., Coelho S.M., Collen J., Corre E.,
RA Da Silva C., Delage L., Delaroque N., Dittami S.M., Doulbeau S., Elias M.,
RA Farnham G., Gachon C.M., Gschloessl B., Heesch S., Jabbari K., Jubin C.,
RA Kawai H., Kimura K., Kloareg B., Kupper F.C., Lang D., Le Bail A.,
RA Leblanc C., Lerouge P., Lohr M., Lopez P.J., Martens C., Maumus F.,
RA Michel G., Miranda-Saavedra D., Morales J., Moreau H., Motomura T.,
RA Nagasato C., Napoli C.A., Nelson D.R., Nyvall-Collen P., Peters A.F.,
RA Pommier C., Potin P., Poulain J., Quesneville H., Read B., Rensing S.A.,
RA Ritter A., Rousvoal S., Samanta M., Samson G., Schroeder D.C., Segurens B.,
RA Strittmatter M., Tonon T., Tregear J.W., Valentin K., von Dassow P.,
RA Yamagishi T., Van de Peer Y., Wincker P.;
RT "The Ectocarpus genome and the independent evolution of multicellularity in
RT brown algae.";
RL Nature 465:617-621(2010).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the TPPP family.
CC {ECO:0000256|ARBA:ARBA00010994}.
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DR EMBL; FN647904; CBJ49059.1; -; Genomic_DNA.
DR STRING; 2880.D7FJ20; -.
DR EnsemblProtists; CBJ49059; CBJ49059; Esi_0125_0068.
DR eggNOG; ENOG502RKVS; Eukaryota.
DR InParanoid; D7FJ20; -.
DR OrthoDB; 56123at2759; -.
DR Proteomes; UP000002630; Chromosome LG18.
DR GO; GO:0015631; F:tubulin binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0046785; P:microtubule polymerization; IEA:InterPro.
DR Gene3D; 1.20.5.190; -; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR008907; TPP/p25.
DR InterPro; IPR000315; Znf_B-box.
DR PANTHER; PTHR22706:SF1; ABNORMAL SPINDLE-LIKE MICROCEPHALY-ASSOCIATED PROTEIN ISOFORM X1; 1.
DR PANTHER; PTHR22706; UNCHARACTERIZED; 1.
DR Pfam; PF00612; IQ; 3.
DR Pfam; PF05517; p25-alpha; 1.
DR SMART; SM00015; IQ; 11.
DR SUPFAM; SSF47473; EF-hand; 1.
DR PROSITE; PS50096; IQ; 9.
DR PROSITE; PS50119; ZF_BBOX; 2.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00024};
KW Reference proteome {ECO:0000313|Proteomes:UP000002630};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00024};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00024}.
FT DOMAIN 1034..1079
FT /note="B box-type"
FT /evidence="ECO:0000259|PROSITE:PS50119"
FT DOMAIN 1168..1209
FT /note="B box-type"
FT /evidence="ECO:0000259|PROSITE:PS50119"
FT REGION 164..228
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 435..462
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 164..217
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1606 AA; 181031 MW; E0EDDA1E6AB6D257 CRC64;
MAATAEVRVR QHAGCDDLDG EVTLPCILDR LSRLEHDSCS YHELLDDFAS RRRVGPVKKE
LPAKHVLDPA EEADEIVQRV EQAARNFSAQ KLDRKKPGGL YSTIGRRQVG LVETDIDDLT
ATITSRTEVL AAAKSTAVAK SLTEHSNGVL AGLLRPDKTT TLPTISPSCF QDPLDSSSPI
TGSPKRSPFS RSTTKIRRSN GRGPSEPAAT ATTAGASAEE SEEGLEMSER MKVIGVDESQ
HREDLADNLR RLRTLLGEPE DKVEARRSGS PSVLSVRELR AIGAAQRQRL QHTTKMEGAD
ALAVGRGTQQ GSTDEGVQQE RAADELGAKG NVLLRDLAKT LFSSMQFRAQ KEFLLLAFRK
WKVSTPSDTA CPDYSFPSSN QIHRAVKTVS GESVLAGYLG ATVLIQRSLR RTLAITEAAE
RRRLRDNQAK SSVDAAEVDS WGERSPTSAT EAVPVAGHTQ GATGCEERFR REGAVTRIQA
VWRSRVLKRN LSALVRIGKR TRAIRIQRAA RVYLAKKELH KRKEAFLIRY ADEIASAIKI
QSIVRRKIAW NRVDERRFQR SKEQLVSTMD AERALRNRTI EVPRIKAVAA REGAVLSAQG
KGMPYIIDPV ALKILLADKR RAINPWQEST DRKAATKIQA LFRSHRQVVR IRRMRVQRRR
QDAEARREAQ YRAANNLQRV FRGRRARVEA KSRRYGLRAV RVQKVWRGFL GKRAAADRRQ
RVQAATVLQR RLRGAQARSL AARVRREAVT TSAPAIAIQA TARRYLARRR RNKLVKAKQI
EWEMTTMAKE MSRFCVERAR LRKIAVKRSG EEGSGSFRLE GRAFNKLFAS TPGVFSSSFL
ATDVDLVFAR VKDKDEKTLT YAQFAAALNV VAATLFPKTK RFRDFLAFKA KAARLLELVE
GKVLKAPGAT EYRKFCQKAG ERFVFRSANK IQATIRGYLG RKRFRQKQLE SDKVARTALE
SLEVVKLQSL GRRYCARCRA IRLAQAKISK FIDPTTHLPY WLNATTGVTT WTKPKVFGAA
DVEHAMMVAT SKTEHLVICS VCDVRPVRRM CTSCRDSYCE ECFQALHGRG KRRAHVAPVI
HMCCVCKYQH ATRICETCTF KTSTTSAYCD VCFFNKHPGL DNLSKAEAAA IEEGRGGGGG
GGAKAWALTA ARKQEGWNHR WTPLVVTCVE CRRYAARWLC DDCEEVYCVG CYAFVHRHGT
KVNHGAEKLP YYPASLHMEY AMACRKRSRK ERDEEARSLW LEDQGRAKER AAVRIQARWR
GKIGRIEGLA HLKAGRARHR AEWRQRKKDD RKRNALWYEA LDLAGIVRRG FDFGTVDELK
DQAERGGIRL PGGHTVKTGH RCIYTDPAYV MGDFLKPKNI IRVQGELFKV ETVEADRIRV
DRVWNKRGSK RVLLYKMVLN PRQKLLLGAS RAFWSSQAVQ YGIQVTLVLE EDVINRMLRN
AAKYYKRKRR KRLYTLAKKT LKKSEEHVGS LKLKLNVAQF GLDNSLLSGD LDGENKAAAA
DDGAPETAES ALAWIEVMNE VRLKCARRPW GEFGAPFVNL QFIISELLSS RSWKEDLQTT
GRPLWRNTVT GEESSVPPKG MANIEKMTND LEKQKQMLRA KKAKKR
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