ID D7FLS8_ECTSI Unreviewed; 732 AA.
AC D7FLS8;
DT 10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT 10-AUG-2010, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE SubName: Full=Putative subunit of the Anaphase Promoting Complex {ECO:0000313|EMBL:CBJ29753.1};
GN Name=APC8-cdc23 {ECO:0000313|EMBL:CBJ29753.1};
GN ORFNames=Esi_0160_0056 {ECO:0000313|EMBL:CBJ29753.1};
OS Ectocarpus siliculosus (Brown alga) (Conferva siliculosa).
OC Eukaryota; Sar; Stramenopiles; Ochrophyta; PX clade; Phaeophyceae;
OC Ectocarpales; Ectocarpaceae; Ectocarpus.
OX NCBI_TaxID=2880 {ECO:0000313|EMBL:CBJ29753.1, ECO:0000313|Proteomes:UP000002630};
RN [1] {ECO:0000313|EMBL:CBJ29753.1, ECO:0000313|Proteomes:UP000002630}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ec32 / CCAP1310/4 {ECO:0000313|Proteomes:UP000002630};
RX PubMed=20520714; DOI=10.1038/nature09016;
RA Cock J.M., Sterck L., Rouze P., Scornet D., Allen A.E., Amoutzias G.,
RA Anthouard V., Artiguenave F., Aury J.M., Badger J.H., Beszteri B.,
RA Billiau K., Bonnet E., Bothwell J.H., Bowler C., Boyen C., Brownlee C.,
RA Carrano C.J., Charrier B., Cho G.Y., Coelho S.M., Collen J., Corre E.,
RA Da Silva C., Delage L., Delaroque N., Dittami S.M., Doulbeau S., Elias M.,
RA Farnham G., Gachon C.M., Gschloessl B., Heesch S., Jabbari K., Jubin C.,
RA Kawai H., Kimura K., Kloareg B., Kupper F.C., Lang D., Le Bail A.,
RA Leblanc C., Lerouge P., Lohr M., Lopez P.J., Martens C., Maumus F.,
RA Michel G., Miranda-Saavedra D., Morales J., Moreau H., Motomura T.,
RA Nagasato C., Napoli C.A., Nelson D.R., Nyvall-Collen P., Peters A.F.,
RA Pommier C., Potin P., Poulain J., Quesneville H., Read B., Rensing S.A.,
RA Ritter A., Rousvoal S., Samanta M., Samson G., Schroeder D.C., Segurens B.,
RA Strittmatter M., Tonon T., Tregear J.W., Valentin K., von Dassow P.,
RA Yamagishi T., Van de Peer Y., Wincker P.;
RT "The Ectocarpus genome and the independent evolution of multicellularity in
RT brown algae.";
RL Nature 465:617-621(2010).
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DR EMBL; FN648144; CBJ29753.1; -; Genomic_DNA.
DR AlphaFoldDB; D7FLS8; -.
DR STRING; 2880.D7FLS8; -.
DR EnsemblProtists; CBJ29753; CBJ29753; Esi_0160_0056.
DR eggNOG; KOG1155; Eukaryota.
DR InParanoid; D7FLS8; -.
DR OMA; ARMWIAM; -.
DR OrthoDB; 3131281at2759; -.
DR Proteomes; UP000002630; Chromosome LG09.
DR GO; GO:0005680; C:anaphase-promoting complex; IEA:InterPro.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 3.
DR InterPro; IPR007192; APC8.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR12558; CELL DIVISION CYCLE 16,23,27; 1.
DR PANTHER; PTHR12558:SF10; CELL DIVISION CYCLE PROTEIN 23 HOMOLOG; 1.
DR Pfam; PF04049; ANAPC8; 2.
DR Pfam; PF13414; TPR_11; 1.
DR Pfam; PF13181; TPR_8; 2.
DR SMART; SM00028; TPR; 5.
DR SUPFAM; SSF48452; TPR-like; 2.
DR PROSITE; PS50005; TPR; 4.
PE 4: Predicted;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Cell division {ECO:0000256|ARBA:ARBA00022618};
KW Mitosis {ECO:0000256|ARBA:ARBA00022776};
KW Reference proteome {ECO:0000313|Proteomes:UP000002630};
KW TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339}.
FT DOMAIN 2..104
FT /note="Cdc23"
FT /evidence="ECO:0000259|Pfam:PF04049"
FT DOMAIN 175..246
FT /note="Cdc23"
FT /evidence="ECO:0000259|Pfam:PF04049"
FT REPEAT 307..340
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 341..374
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 375..408
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 409..442
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REGION 108..171
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 533..732
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 114..132
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 534..558
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 580..600
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 732 AA; 77449 MW; 3C8EFDA44957F29A CRC64;
MDVGEFERAS QAFGNKSWPA AAAAGSVPGG LYSRARFLGW YSLFLAGERR REEESQLTDA
LQRRRLVNPH LKTLHAELSQ CDQAGTLDAF GLYIYAAVLK ALREEGRGGA GGTGGNTPTP
TTPHSSGGGG GANSLGGSGG GAFVTPRARA PSGGRGDATG GGGGTTSTEK TAVTTATAQE
VLARSLRLFP YNWSAWLDLA SLCLETDTFF LQHLLVEQHL SKDALAILDD LEPSFPCSSY
VLSQTAVAHY HLRNFDQGHD DFKELRRRDP LRMEGLDVFS NILYVKECKA ELSFLAHTTN
KSAPLRPETN CIIGNYYSLK GQHEKAVTYF LKALRLDRRC LSAWTLMGHE FIELKNSGAA
VESYRQAVDI NPKDYRAWYG LGQAYEILHM HLYAIYYYKR ATALRPYDAR MWIAMGQCLE
KLGKSAEAIS TYERAMANDD REGIALAQLA KLYDGAGRKD SAAKCYETML ANRSADGDNS
SAEEGMHFLC LYYKNKGDYT RASKMANGLL DYTGTSREAA LAVLREIRSI METRQHQAAE
SSALPQPHNA NNSHDDVSLD GGSGRPLFTP RAATGSSHHD GSGAGGSQLF NANNSGLGGS
VRGATRAAAG TFPTPTPRRP GRVRNGVSPG TGGGGGGAAG GGAGSGTPGY RLMGNSGGGT
SLAPRSPEDM SVAMSLGSSD EDDDGGALAR YSPGIATPVA TGHGGAGAGH DGSPEAGGDG
QGEESLSDIL SP
//
