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Database: UniProt
Entry: D7FMW8_ECTSI
LinkDB: D7FMW8_ECTSI
Original site: D7FMW8_ECTSI 
ID   D7FMW8_ECTSI            Unreviewed;      4347 AA.
AC   D7FMW8;
DT   10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT   10-AUG-2010, sequence version 1.
DT   22-NOV-2017, entry version 31.
DE   SubName: Full=Inositol triphosphate receptor (IP3R)/ Ryanodine receptor like protein {ECO:0000313|EMBL:CBJ30032.1};
GN   ORFNames=Esi_0171_0052 {ECO:0000313|EMBL:CBJ30032.1};
OS   Ectocarpus siliculosus (Brown alga) (Conferva siliculosa).
OC   Eukaryota; Stramenopiles; PX clade; Phaeophyceae; Ectocarpales;
OC   Ectocarpaceae; Ectocarpus.
OX   NCBI_TaxID=2880 {ECO:0000313|EMBL:CBJ30032.1, ECO:0000313|Proteomes:UP000002630};
RN   [1] {ECO:0000313|EMBL:CBJ30032.1, ECO:0000313|Proteomes:UP000002630}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Ec32 / CCAP1310/4 {ECO:0000313|Proteomes:UP000002630};
RX   PubMed=20520714; DOI=10.1038/nature09016;
RA   Cock J.M., Sterck L., Rouze P., Scornet D., Allen A.E., Amoutzias G.,
RA   Anthouard V., Artiguenave F., Aury J.M., Badger J.H., Beszteri B.,
RA   Billiau K., Bonnet E., Bothwell J.H., Bowler C., Boyen C.,
RA   Brownlee C., Carrano C.J., Charrier B., Cho G.Y., Coelho S.M.,
RA   Collen J., Corre E., Da Silva C., Delage L., Delaroque N.,
RA   Dittami S.M., Doulbeau S., Elias M., Farnham G., Gachon C.M.,
RA   Gschloessl B., Heesch S., Jabbari K., Jubin C., Kawai H., Kimura K.,
RA   Kloareg B., Kupper F.C., Lang D., Le Bail A., Leblanc C., Lerouge P.,
RA   Lohr M., Lopez P.J., Martens C., Maumus F., Michel G.,
RA   Miranda-Saavedra D., Morales J., Moreau H., Motomura T., Nagasato C.,
RA   Napoli C.A., Nelson D.R., Nyvall-Collen P., Peters A.F., Pommier C.,
RA   Potin P., Poulain J., Quesneville H., Read B., Rensing S.A.,
RA   Ritter A., Rousvoal S., Samanta M., Samson G., Schroeder D.C.,
RA   Segurens B., Strittmatter M., Tonon T., Tregear J.W., Valentin K.,
RA   von Dassow P., Yamagishi T., Van de Peer Y., Wincker P.;
RT   "The Ectocarpus genome and the independent evolution of
RT   multicellularity in brown algae.";
RL   Nature 465:617-621(2010).
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DR   EMBL; FN648224; CBJ30032.1; -; Genomic_DNA.
DR   Proteomes; UP000002630; Chromosome LG14.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005216; F:ion channel activity; IEA:InterPro.
DR   GO; GO:0006816; P:calcium ion transport; IEA:InterPro.
DR   Gene3D; 1.25.10.30; -; 1.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR035910; IP3R_RIH_dom_sf.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   PANTHER; PTHR13715; PTHR13715; 3.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002630};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000313|EMBL:CBJ30032.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002630};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   3830   3850       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4056   4074       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4109   4133       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4201   4220       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       60    144       Ins145_P3_rec. {ECO:0000259|Pfam:
FT                                PF08709}.
FT   DOMAIN     3436   3540       RIH_assoc. {ECO:0000259|Pfam:PF08454}.
FT   DOMAIN     4054   4230       Ion_trans. {ECO:0000259|Pfam:PF00520}.
SQ   SEQUENCE   4347 AA;  458877 MW;  E0932C73DB7104A3 CRC64;
     MLRVGERVLL LALSEERDKH PLGYLSSRLL MDAEGRSSFA TLDCSLTSFR DAPPAERSWE
     PVVVSDCVFR VAACVDRHDA TRASQSQRNL EPGNTVHRGM QPGTPVRYSK AVQLVHEFSG
     ALLCIDVQER AESEGFAMKV VLKAIDPPSG DGGSTDGYKN TWWEVKSPGN VRISQVLHYD
     EICLHSNRWD RSVRAHPTLL DRQRVTSATE VEGESGTEEA GAATGLSPTL PREKYPGAVH
     ASFSHSLLRV VPYDDCPSLP YSDEGLSIAT TSAATVMASA SGGWPGPDSS SSPHALAGSG
     TADTPVGGVA DDAGAIRGGD VVRLCHLRST GFLTCEVVTP EAFPRGGWAQ PEPRMVGQAG
     GGGGGRRGGG GGGVDGPVQG QASDGGVGGG PFLYISATPH RRLKLQNASS NCLWVLERTH
     CALGGRPLRG SCASAAGAAD PPQQHQQQGG NPTSSSVFST GGSGNARRNS LHQQQTAQHS
     GNSSAYTGGA AAAGAGYSPG DGGGGNRSGA TERQRWNSDS DYFPGGNEGG ARGGGGGGGS
     TGGASGTRPS SSFPGGGFGR DTYAEAVAKR RRRQGAGDPV EYVRIKHLAT MRYLCVGKKC
     DPVRGGGGVN AGGDAGASGT PATRRRGDSR RRGAAAADAA ATRVGMLTVD QHAAVPAATV
     FVIRPRRTAA AGAEGLVGPA AAEGAGADRW LGPEDLVHLQ HKNTGLFLSA LPLENTAKGG
     IGLTMVKSPL TTEYWRLARA PERERMATNH ILTAQAQLKA SLDSLLVEIE KMPPFDAAGK
     KNNTDGRAPA APPSAAYLYP PVPYARFIRP AALAVSHFHS VLSRGAAWWG GGGAGTKKFP
     PSVSSSRGHS LAGHSGGGDA PSAGGRGLMS MGERLGKASS SSRRISVGGR SGGEEAAARV
     IIGRKRERSR HNVLGGLSGG GGGGGGASGV SGGGASGALG GGVSSLMISL DEFHANPRLR
     FQLLLREQGI VVQLFESMWT IFREQDGILA RHLWWDDDAE ESASGSTTVS IGPPAFSATP
     RSGATRVGGT DVGGGSNTDE WEIRRDRSAA RHCLRQFVVQ AMALADFFAR DNPRGKAVLE
     NFTPLLRMLI GSGLGACEVL ATIRRDNPRT YAVVTPARIQ QILATLPESR DLANSMRLLR
     SICKVGHSLL PSIQRLVAVT VLVGVDTAAA AAAGRAAGGG SEFGSGRALG GGGGGGGGGG
     GSGRKDSDEG DGGGEHGVSV AASLEGEENH LLRNPRSLFR YELIRDMDVT TSDVDASGAA
     ASGTSTDRGN GSGGTLAGGA SVSRPSLTPS ASESGRGKAS SISSSVKSQR RRPSLRAASG
     TNFRSADGTK GIRVRLKRLV AGVSMGEQLR RRRELLNGET RVSSGEGVIF EAVQEGSGSA
     SRTVVRVLSR GGAGEPPVEG PWGPRGSGRG AGPSSAAGDL LELFVESVRL LASLCQERHK
     GNIALVRSLK GTTYKELMEV VRSETVPPTV RAAFAQLLEH CHLNVAPLLP RPPVRYVRLK
     DDDDEDTYDS SSDDDDDGDQ SSFSGRGRGR ANERKDSANP VDQGVAAVDA ADFAEGKSED
     TRKIDEGEEQ REHLRDALEF VQAFVKKHTR PGGTLQIDQW NSGGGDRFMD QHWDPIDVEE
     LSPGVDGVGS SSFLADSFHE AFDPTRRQKQ LQRQRRPSAS GKGVSRPDTT PALAAASSGT
     SVHTRMHAPP LSAMSKALQL TENLKLLGAV LSLLRLTLDL LGRQPLGTDP SAGLFRRLCS
     LLEFLEDVRE MRSEFLAAGG ARGGGEGAGG GDAGGGGGGG GGGGGGGRSG MFGGTSRRES
     SVGGGVGSGA KISSASKLLG SLADEDAVGI TDTEVSVMRV LTLLLGHELD KQLDKVLWLA
     RKYDKNENAF RFSFDASTDK MVATYKGKDI WSLVHNSGGA GLLAGREGEI NAHNLSNLSG
     TLLRLAVAGQ ESGRAGGPTL TARSFALLFR ISDQGNQLAR EARKVTQLTG RAASETHRGL
     NRAVMALRAF SRRRAGRPAM LADTVGNSNG RNVLVGGSSE RLAAQSPPPP PTTTKPLPRK
     GTGESGAPVK VTRTAAARGE EDGGTGASPP DEAGADVARA RSLSAIFSAA PPRLAPAPSA
     QDAPAAPVSA APTGLGTDLI SALQAEEKSV SEALGEVRRV LMAGREDADG AQAEVERVAA
     GVGLPAALLG ALRALRREDY AGAGAGGNGG SNWLSLAKEI MQLLRLLVEQ GPNPDLRRLL
     FSNFSLLLSF LDVGAPSPAA ASSSQQAVVV GGGGGGGDGR SGGRRLFFAS PVARLMGEVV
     NQDYVLVTSV SEEHLTQLAM AATRSREADL LVLLQKLVTC NGAPVQNMQR RVLVTLLREL
     SRTDFHAAFG WDDLRPSLQP PASRPQRNPR VQHQRAGSGG HDNSDLPRYS PDDGDGSTPP
     PPPVTSTLPR SPPAPVPADD HRTRAGGAEQ TPALGETTPG SSATAGAGWS GDGGGSGGRD
     YSGQRTAREE AQSTHEQESH WRRWGRVEDS ATSGLGFMSA LQRALILEQQ QRQQEAEETD
     DGSSGDDDGE DGWRGGGDRA KREAGGDRHA LELLSVIAAC CEGKNHFTEV QCRSMVSLEE
     LVTLVTRGAP GGALSGRGRG GDAATAAGGA VSSPESKAYD GGGGRISVVA ETKIPGEVGR
     RNAGDETGEE KRAQEEDDGG VEEQKQSLPQ RQQDSNGGNG DENGPSVTAA VPGAPQLVGA
     AQSSSASEEP GLPIRGDRLP SNSSLVGAST SSWFRDRPEE SGAGSGGGAG SAGGDGGERP
     LPAGVRWAFM WLLDSLFFNV KEPVEGLDRH PVVHALLENL LTTTQFCVRV PASKRWENEE
     IDFIISTAVP LLHNFFEGCW RDPLPFVTKT AVMLVSTLAV LFYALAEDVR SLAEDAGLKW
     RWQKVEGSEV DEGVWEGDCD KETKSRLEWR KRKLRSLRDL VFELYLSGDR RKRDLFSLFY
     AEKRRLEVDT TGGSDGGSRG GSGDVGGDSD ATGDGNGARG RGGGRGKSED RFNDLMVVIQ
     NLARIAEDSE TSGSDSALGD SEADHHHQQQ MEGGGTAGRP RGGSRDMSEA LARAYWSTSG
     DGATVRGSRT FSWTANVRSV RMTSSGGSRG FFRDQGHAGE DTWQSLRASA PDLHPRLPRG
     PGGGPGGGGR RGGSSTFPSF RVGGGGADPA GDRRGGAPRL QLSEHGVLPL LEASVTGSGE
     LEKLVSDLQQ SSRDDHVFGL HILRAVIETA PPVGDGSEGL PGMWQPGGGA DGGGGVSTNE
     STRGRKVDED AIRDNQEKAG RRLQQERIAG LGGGSTILLF VGGLSSSSTR DTAGDAFLLA
     VEMLKGGNKQ VQEHFYAVLR ESRQDEYFFE AVTNFIRASV TRLADCRRRR LVLKRRGAVE
     KKGAAASKAA AARAPTGSTR RQAKATIANM SITVVEPGAV GSGESGAYGG PGADGEDQAP
     PAALPAAGMA AGEGEEEVAS LSALMEFLRL LCENHYLDMQ DYMRRQPDNL RTYNMVTEVC
     ALLQGLEWVT LDDVRHWGID ARTIDLAFTV VRTLVEFAQG NEGNKRAIAT PSLTGSINDL
     FRKRFDGRDH GESVLAAHQR GECRTSPARL KHQAFVLLYS LIEGCHEPSV FFTLLHTLDF
     EAILGVLQDA REAFAVASRD YRMKERTYLK LRRARWRSGV LLVFKGWKRK LKAATEEHKR
     SEEQWESARR GCSTPVLFLR ALFDGGRADN PEKCAEEEAR FESFLDEWQG AVRSIEIKRE
     GRLEKMYFVV PEWCRAHWKK TPVIEMRELM KKRCARATSS PGWKLLKFYQ QGEGMLSQMA
     YLHTLQASSL HVVTGKEEMW SALTFLLALA INLSDIAASG ESEKEGDRVY LAGTVLGAAH
     VVISCLRLVA FMYNRQQKWL YEHNLPDLAM LRRVLRLGPQ RVGEDVSPRG QAARGDKQQI
     STSSAGVNTA ATPLVLSPSP SQEVTDPVGV AASLSRSGGG FADSRGVAGG GEGTNALGLR
     RGVQDRILRL AKEYSQESYD SNGSWGGGGW GSGGGGMSSY DSSSSDSDSE NREEAEMRAW
     GGGGGGGGRG VGGRGKEVGR VDRLTRMAVM LSSSKWNVLY VLVSLVGFVL SLRFEFKGRS
     ACYAFCLLDV SVRYRAMHRV LRAVSQNSAM LWQTAMLVVV VLFIFAAVGT AWFEDDFALA
     SAVEAVGDDD SAEGFSGCST LGECSITLFQ YALRGDLGTY LLLMTDQDEP GHRIRRFLYD
     VAYWVLVPLL LLNMVSGVIL DSFAQLRDEE AALKDELKSR CVVCGISRNE FDRGGNVFYD
     HVTHDHCMWN YVLVRAYLHF KPELEHTGQE SYVHKLQRGG PDGVPDVRYF PVGEAGVLEN
     ASSRGGRRRG EGALGGAEAA RGGTRVW
//
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