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Database: UniProt
Entry: D7FPY6_ECTSI
LinkDB: D7FPY6_ECTSI
Original site: D7FPY6_ECTSI 
ID   D7FPY6_ECTSI            Unreviewed;       975 AA.
AC   D7FPY6;
DT   10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT   10-AUG-2010, sequence version 1.
DT   07-JUN-2017, entry version 21.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   ORFNames=Esi_0002_0045 {ECO:0000313|EMBL:CBJ48318.1};
OS   Ectocarpus siliculosus (Brown alga) (Conferva siliculosa).
OC   Eukaryota; Stramenopiles; PX clade; Phaeophyceae; Ectocarpales;
OC   Ectocarpaceae; Ectocarpus.
OX   NCBI_TaxID=2880 {ECO:0000313|EMBL:CBJ48318.1, ECO:0000313|Proteomes:UP000002630};
RN   [1] {ECO:0000313|EMBL:CBJ48318.1, ECO:0000313|Proteomes:UP000002630}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Ec32 / CCAP1310/4 {ECO:0000313|Proteomes:UP000002630};
RX   PubMed=20520714; DOI=10.1038/nature09016;
RA   Cock J.M., Sterck L., Rouze P., Scornet D., Allen A.E., Amoutzias G.,
RA   Anthouard V., Artiguenave F., Aury J.M., Badger J.H., Beszteri B.,
RA   Billiau K., Bonnet E., Bothwell J.H., Bowler C., Boyen C.,
RA   Brownlee C., Carrano C.J., Charrier B., Cho G.Y., Coelho S.M.,
RA   Collen J., Corre E., Da Silva C., Delage L., Delaroque N.,
RA   Dittami S.M., Doulbeau S., Elias M., Farnham G., Gachon C.M.,
RA   Gschloessl B., Heesch S., Jabbari K., Jubin C., Kawai H., Kimura K.,
RA   Kloareg B., Kupper F.C., Lang D., Le Bail A., Leblanc C., Lerouge P.,
RA   Lohr M., Lopez P.J., Martens C., Maumus F., Michel G.,
RA   Miranda-Saavedra D., Morales J., Moreau H., Motomura T., Nagasato C.,
RA   Napoli C.A., Nelson D.R., Nyvall-Collen P., Peters A.F., Pommier C.,
RA   Potin P., Poulain J., Quesneville H., Read B., Rensing S.A.,
RA   Ritter A., Rousvoal S., Samanta M., Samson G., Schroeder D.C.,
RA   Segurens B., Strittmatter M., Tonon T., Tregear J.W., Valentin K.,
RA   von Dassow P., Yamagishi T., Van de Peer Y., Wincker P.;
RT   "The Ectocarpus genome and the independent evolution of
RT   multicellularity in brown algae.";
RL   Nature 465:617-621(2010).
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
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DR   EMBL; FN648375; CBJ48318.1; -; Genomic_DNA.
DR   HOGENOM; HOG000037059; -.
DR   InParanoid; D7FPY6; -.
DR   OMA; WTAYDAH; -.
DR   Proteomes; UP000002630; Chromosome LG02.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002630};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002630};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    520    544       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    564    583       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    652    672       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    679    703       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    780    798       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    909    934       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED      127    161       {ECO:0000256|SAM:Coils}.
FT   COILED      196    223       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   975 AA;  108449 MW;  B50AFFC6042FA417 CRC64;
     MFARRVPLTA VLRRVSTTDG SDSLFTARQP PVPSRRRVVQ LAATGNRQGR SRRPSLEGGS
     KEHTVLSLRE TESPLAGASS SRTMARWFRS EDMAYVSIIV NEDAAHTCIS DLGKLGMIQF
     TDLNPELTAF QRRYVAYIKR IDELERKLAF FGEEVKKFDL KVASAGTVES FVQSSSAQGV
     GSGAEAKSVL GGQALLQKLE ADLEALESHL VELNTYNERL TSEYNEKVEL QEVLLKTKGL
     FAAEMPHMQI EEQSMGARRY QDVERGSVQV SGGGVQPTRE SDMKFSYIAG VVGADDRSRF
     ERQLFRTTRG NCYVRFAEIE QPISDPTTGE QVMKLVFIIF YKAAAIESKI KKICEAFRAK
     RYDLPEMDDG EGVKKLMYDN YGEMHDARVV LLKNRDARMS LCATAADRLE SWTWTVLREK
     AVYHTLNTFK PDVRGILRGE GWVVQEGMGG VQMAVNRAHA EMDTGMPSMV EVMPKPWPTP
     PTYFKLNAFT IAFQEFVDTY GVPRYKEANP ALFTAASFPF LYGIMFGDIG HGTVIMFLGL
     FLVFTHGSVA GRRDLGELAG GLYLARYMIT MMGFFSVYAG LIYNDFFSLP LNLFGSSWVW
     SDGIDTEEGE EADSVSFYGD ADAVYPFGVD PAWHIAGNEL LFFNSMKMKT SVILGVTQMT
     FGVVLKAMNA LYFKESLDFF YEFIPMIIFV LSLFGYMIVL IFMKWSIDWD YRMYTATCFD
     GLTPQNVTCD SDSTTADMCP LDYGGSGDGC QPPNLITSLI NIALSPGTVD EPMYAGQTSV
     QTILLLLALG SIPVLLLAKP LTIRSRMKKA AARHDSFSSE SQLMAGEHNS SDKVDNGGHG
     AAGGDHGGHE EHDFSEIVIH QAIETIEFVL GMVSNTASYL RLWALSLAHT ELAAVFWEKT
     MLTTIQMGNA FAIFIGFAMF AGVTFGVILC MDVLECFLHA LRLHWVEFQT KFYKADGYKF
     APFSIAAIVK EAPVM
//
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