ID D7FR21_ECTSI Unreviewed; 2289 AA.
AC D7FR21;
DT 10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT 10-AUG-2010, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE RecName: Full=EF-hand domain-containing protein {ECO:0000259|PROSITE:PS50222};
GN ORFNames=Esi_0021_0178 {ECO:0000313|EMBL:CBJ26175.1};
OS Ectocarpus siliculosus (Brown alga) (Conferva siliculosa).
OC Eukaryota; Sar; Stramenopiles; Ochrophyta; PX clade; Phaeophyceae;
OC Ectocarpales; Ectocarpaceae; Ectocarpus.
OX NCBI_TaxID=2880 {ECO:0000313|EMBL:CBJ26175.1, ECO:0000313|Proteomes:UP000002630};
RN [1] {ECO:0000313|EMBL:CBJ26175.1, ECO:0000313|Proteomes:UP000002630}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ec32 / CCAP1310/4 {ECO:0000313|Proteomes:UP000002630};
RX PubMed=20520714; DOI=10.1038/nature09016;
RA Cock J.M., Sterck L., Rouze P., Scornet D., Allen A.E., Amoutzias G.,
RA Anthouard V., Artiguenave F., Aury J.M., Badger J.H., Beszteri B.,
RA Billiau K., Bonnet E., Bothwell J.H., Bowler C., Boyen C., Brownlee C.,
RA Carrano C.J., Charrier B., Cho G.Y., Coelho S.M., Collen J., Corre E.,
RA Da Silva C., Delage L., Delaroque N., Dittami S.M., Doulbeau S., Elias M.,
RA Farnham G., Gachon C.M., Gschloessl B., Heesch S., Jabbari K., Jubin C.,
RA Kawai H., Kimura K., Kloareg B., Kupper F.C., Lang D., Le Bail A.,
RA Leblanc C., Lerouge P., Lohr M., Lopez P.J., Martens C., Maumus F.,
RA Michel G., Miranda-Saavedra D., Morales J., Moreau H., Motomura T.,
RA Nagasato C., Napoli C.A., Nelson D.R., Nyvall-Collen P., Peters A.F.,
RA Pommier C., Potin P., Poulain J., Quesneville H., Read B., Rensing S.A.,
RA Ritter A., Rousvoal S., Samanta M., Samson G., Schroeder D.C., Segurens B.,
RA Strittmatter M., Tonon T., Tregear J.W., Valentin K., von Dassow P.,
RA Yamagishi T., Van de Peer Y., Wincker P.;
RT "The Ectocarpus genome and the independent evolution of multicellularity in
RT brown algae.";
RL Nature 465:617-621(2010).
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DR EMBL; FN648387; CBJ26175.1; -; Genomic_DNA.
DR STRING; 2880.D7FR21; -.
DR EnsemblProtists; CBJ26175; CBJ26175; Esi_0021_0178.
DR eggNOG; KOG2106; Eukaryota.
DR OMA; VWRWQET; -.
DR OrthoDB; 2959353at2759; -.
DR Proteomes; UP000002630; Chromosome LG14.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd00051; EFh; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 6.
DR InterPro; IPR024977; Apc4-like_WD40_dom.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR005108; HELP.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR13720:SF33; HELP DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR13720; WD-40 REPEAT PROTEIN; 1.
DR Pfam; PF12894; ANAPC4_WD40; 1.
DR Pfam; PF13499; EF-hand_7; 1.
DR Pfam; PF03451; HELP; 3.
DR Pfam; PF00400; WD40; 7.
DR SMART; SM00054; EFh; 2.
DR SMART; SM00320; WD40; 21.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 4.
DR PROSITE; PS00018; EF_HAND_1; 2.
DR PROSITE; PS50222; EF_HAND_2; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 5.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Reference proteome {ECO:0000313|Proteomes:UP000002630};
KW WD repeat {ECO:0000256|PROSITE-ProRule:PRU00221}.
FT DOMAIN 63..98
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 99..134
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT REPEAT 527..557
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 616..657
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 806..847
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 1476..1510
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 1719..1752
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 208..233
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 248..280
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 683..743
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 960..1076
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1758..1822
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 218..233
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 248..273
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 683..708
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 718..743
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 968..1013
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1028..1042
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1049..1071
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1758..1777
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2289 AA; 241672 MW; F51F04E291F18FAE CRC64;
MGQRHGKAVY DSAAKPFLNL SLAAVGTLWE TFNDVADGFG INLHEFLEIC SELGEELQLN
RAKLDKLSTA LFKLLDTDNN GLIDAIEFVS AMACASGMSV TDTLEFVLNC YDFDGTGRLT
IDEISLAFKS TVTGMCKLEG TGAGADAGLK ACPRDVDFEA AAMNAFERRA EGSDRFKVKM
REVIDFCQEQ PEIRSWLDYF DDPAEEEALA AAGSEGKEGG EEGGEDNDIR REGWFPVRTT
NETAVAEDNA FSSARAPQET TTTTTTAGGT AKGKKSATAT PPWMETVKSL VPASFSGQTI
DKTPPDIGAS LEWIHGYNGS TCRNNVRYSA GGEVIYHACR ACVSYNATDH RQRFNLDHTD
DICSFAMHPS GRLAATGEVG TEPKIIIWDT ATMQTVKVIK GFHRRAVTLL AFSENGALLA
SVGQDDNHCL AVHDWEKGKL QHTGPTDMRA VLGCCFEADG GVVTCGDKHA LFWKKERQCF
VKKKGVFGRK ATAQMLICCS RLQGKVITGA ASGHLYVWSG RNCVRSVRGH YGSVTAMFSG
PYGLISGGKD MRVRLWSPKM EPGATFDMSA FGPCPIVHSL CLSNDGTKLL VGVKGCEIYE
VSAADGSDVA GGPVTTSHFD GQLTGLARHP QRAEYATAGS DGTVRIWDAL TRSLLRMTRL
DSAASCVDYS PDGELLIVGF GARNRSTTTP SSGSSTTESS TAKSGSSGSK GRRGIGGGSG
KNNTSSSKGL GSEAGSSDSG GGNAKTGGFI VLNEADFITV FEARDAKQGI IEVRWSPDRD
TVVLGGEDSN LYLYATGENY DLIATAAKHK HPVTSVDFSK DGDWIRSTCK GGQLHIWDTN
KGNHQSNITK YKDVEWSTET CAFTWATRGI FTGTEGDGAR ISCTDRSPNG LVVAVGDGYS
RLRLYRHPCP GDRPPPALFH ELRGHGSGGV SRARFLRGGE VLVTLGESDR CVLQWKLSGA
GAGDSRSGEL KDSAEAVAEE ESDGYILDLK DGSDLDRGSD FETAAEERRR VPAYGGARKR
RRAAAVSDQG PTETTNTAAG TGFDGGKASL PPPPRPWEQA TVAPSRPPPT DKSAPADGVE
LERIHGYRGR DSRSNAVYAG ADEVGGGGGC NRAVYTSAAA GVSLDLTNHT QNFQLGHSGD
ATCLAALPDG LLVATGDVSR RPTIIVWKPD TGEAVKTLSG FHRRAITALS FSRDGRHLAS
LGCDDDHSLA IYDWENSLLR ATAKGGRRKA LDVAWNSAGT RLVTCGLRHV SFWNFAGGRN
LLHSRGVFGG KGRKQTLPCC VFVGDTAVVG TGDGHLYVFE NGATTLTRSV KAHTGSVYTL
HPVFSAAPVK AAAASDEQLG YDGSEGQGFW SGGKDGLVKF YNGQLQGVKE FSVATIASNG
VPGGAAGALK ALAGGGGMGK KRLPGAGGSS VSLDPAVRSV FTSRDGRKLL VGTRGGELYE
MSTADGSDAA AVGAGGASGR GSGGGPLTAG HGRGQVWGLS AHPTERLYAT CGDDGSVRIW
SLDDRRVVGS ISTDCSCRAI CYSPDGSALA VGCGGGKGKA DATKSGTFLV LKSENLSLRH
EGKDADDWIR DVNYSSDGAR LAVASNDCKV YIYATKDGFT KLSTIASHQS FVTHVDFSSD
GNYVQSADGA SSLLFADAAT GIQIPSATAM KDIEWGTWTL PFGWAARGVW PIAGNDPGTE
ISCARRSGDS SLLAAGDNFG RLRVFKYPVP IPGSCCSEYR GHCAAVRRVC WSAGDTHLLS
CGVDGSVMQW RMIAEPDAID SGDEAQRSGE DSELEGDGGL RCCSSRKQPQ QQTAMLEEPA
DAADPRTSGG GEAAGGDVAA AGGGETAAAS VGAAMAGVSP SKAKMPWVAA MVPPSNMKMS
DTTAPELRTR LDAVHGCRAE DLRGCVWYNH EEGIVYPVAA LCVIYDPRTG RQSYHESHLG
DVISLTVSSC RRFAASGDAA DPPLVHVWDA VTGAGVVCGG AGGETSGLLP SLHRVGVALL
AFSCDGHWLA SMGHDPEHTL AVYTSPSGQW WDAFPVATAK AGFTRFLCLV FTGQEAFPLL
AGGIKTVSFF DHTDGSRGLR RKRGVFGFRK KIQPVLCAVK MGEDQTTLTG TVTGNLYSWK
AHRVHRSSAG HAGPVYCCAR AGVKGYLTAG KDGFIMLWDA ELQKLKQYGV FESHPASAML
HSICSVGSAC KFVTCTRAGE VYEISKDSGR LLLLADGHGK GQLRGLATHP TDPDVYATVG
DDAFVRVWSL SLRRATLKMK VDSAARSLAF SPSGKHLVVG LGGDRDAMVK EGAVIVLSAE
TLEILEETP
//
