ID D7FR41_ECTSI Unreviewed; 1043 AA.
AC D7FR41;
DT 10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT 10-AUG-2010, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE SubName: Full=Voltage-gated Ion Channel (VIC) Superfamily {ECO:0000313|EMBL:CBJ26108.1};
GN ORFNames=Esi_0021_0051 {ECO:0000313|EMBL:CBJ26108.1};
OS Ectocarpus siliculosus (Brown alga) (Conferva siliculosa).
OC Eukaryota; Sar; Stramenopiles; Ochrophyta; PX clade; Phaeophyceae;
OC Ectocarpales; Ectocarpaceae; Ectocarpus.
OX NCBI_TaxID=2880 {ECO:0000313|EMBL:CBJ26108.1, ECO:0000313|Proteomes:UP000002630};
RN [1] {ECO:0000313|EMBL:CBJ26108.1, ECO:0000313|Proteomes:UP000002630}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ec32 / CCAP1310/4 {ECO:0000313|Proteomes:UP000002630};
RX PubMed=20520714; DOI=10.1038/nature09016;
RA Cock J.M., Sterck L., Rouze P., Scornet D., Allen A.E., Amoutzias G.,
RA Anthouard V., Artiguenave F., Aury J.M., Badger J.H., Beszteri B.,
RA Billiau K., Bonnet E., Bothwell J.H., Bowler C., Boyen C., Brownlee C.,
RA Carrano C.J., Charrier B., Cho G.Y., Coelho S.M., Collen J., Corre E.,
RA Da Silva C., Delage L., Delaroque N., Dittami S.M., Doulbeau S., Elias M.,
RA Farnham G., Gachon C.M., Gschloessl B., Heesch S., Jabbari K., Jubin C.,
RA Kawai H., Kimura K., Kloareg B., Kupper F.C., Lang D., Le Bail A.,
RA Leblanc C., Lerouge P., Lohr M., Lopez P.J., Martens C., Maumus F.,
RA Michel G., Miranda-Saavedra D., Morales J., Moreau H., Motomura T.,
RA Nagasato C., Napoli C.A., Nelson D.R., Nyvall-Collen P., Peters A.F.,
RA Pommier C., Potin P., Poulain J., Quesneville H., Read B., Rensing S.A.,
RA Ritter A., Rousvoal S., Samanta M., Samson G., Schroeder D.C., Segurens B.,
RA Strittmatter M., Tonon T., Tregear J.W., Valentin K., von Dassow P.,
RA Yamagishi T., Van de Peer Y., Wincker P.;
RT "The Ectocarpus genome and the independent evolution of multicellularity in
RT brown algae.";
RL Nature 465:617-621(2010).
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DR EMBL; FN648387; CBJ26108.1; -; Genomic_DNA.
DR AlphaFoldDB; D7FR41; -.
DR STRING; 2880.D7FR41; -.
DR EnsemblProtists; CBJ26108; CBJ26108; Esi_0021_0051.
DR OMA; ACEYAFK; -.
DR Proteomes; UP000002630; Chromosome LG14.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005216; F:monoatomic ion channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 2.
DR InterPro; IPR005821; Ion_trans_dom.
DR PANTHER; PTHR46726; TWO PORE CHANNEL 3; 1.
DR PANTHER; PTHR46726:SF1; TWO PORE CHANNEL 3; 1.
DR Pfam; PF00520; Ion_trans; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002630};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 218..237
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 288..309
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 478..500
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 512..531
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 571..593
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 666..688
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 164..320
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT REGION 704..750
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 779..843
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 858..944
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 961..1031
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 704..719
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 720..734
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 877..892
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 893..915
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 927..941
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1043 AA; 113555 MW; F46B903A55C3BE4A CRC64;
MRSSLTKNFA VLSTSTSAYT TCVAPSRLFG CWCFGGVRRS SREPLTGSPA RATHEDRSQL
PEVQPLVAYD VDKHEVASIY VKDALAGRES PTCIHDQNSL RALKLVRNKA WNQLLNICTI
AHLMLPIVEI QRCLPCMGMQ KIPESLDSNS LHTGWRPTLL GSMWLECLLC LLYVYDLYKV
ALARWSRVTL PFLFISRRTY LKHFVGGVIR VLPRMLPVAF LMSFVVFFYA FIGYVLYRDE
PRSSSLLQDL DLFSQPSSSA MTFLRIFTSI PFMLDVEHIY AGTKGIRVMG LSYGVIMVIF
LGALVPAVAN RNFQYQSKES YNWVKEQRKL ALTRAFMLLR REEDRTVGRE DWVRLMACLR
PDCNAGHTSA LFDAAKKAED ETVSLGGEDD RNRLSKGGFF MLCALGTASF SRARKDDAGS
RRSGSKWKRI RQRLDAALSW SMPGSNFPLS RQVLNVAVVV QGYQIVLEGD DPERRPTWAY
PLGGFLIAYF CVQASLWMIV DGARLYIRQW RHALGMCLNL IGVAYYMGLW FDGTGWHSFY
QILQASRVVI LWNVLHRLGS TSSEVATRLE FVFPAVLRAS FVLFSVTYSY SVLAFDMYCA
TPLGVEPVDS VADHSMMQRW AYYKDVISFA SLHQSFAAMT DVIMLSNWPL FMDAAGDVGN
VVTAKLFFYS FKVLTFYFVM PVMLGFIVQS YMAAHIPGAD SANNKPALSS SSRAVSDSLS
FSRRSHRDGG GRGGAEDGRG GSASPLSSRV KSILETTGAS SIRTIGEVGG VGGGASRLTR
ELGGGAGPAA SLSSSGRSYG DGGEGAASGG AVGDMAGSRS GKASPKARAG GKDGASTTIL
DGSKFATFAG DAVDVDTLLE EGARGDGGSD SGGEDGDGEG GGLDDDDESS SSDDSSAPVV
VTSQARSMSS TFWGAEQEKD HQRRGSSQAS TEMQESLSRM EAENASLRAL VDSMQMDLQM
ANARLYDEMQ TPSRDRSPSP GRTPSRRGSG VDGSAHPGKP PLPLSFISPD SMAPLRKRVG
SGTSSLGGME AIAEIEDEEV GIV
//
