ID D7FSM5_ECTSI Unreviewed; 1048 AA.
AC D7FSM5;
DT 10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT 10-AUG-2010, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=Pleckstrin homology (PH) domain-containing protein {ECO:0000313|EMBL:CBJ31166.1};
GN ORFNames=Esi_0236_0043 {ECO:0000313|EMBL:CBJ31166.1};
OS Ectocarpus siliculosus (Brown alga) (Conferva siliculosa).
OC Eukaryota; Sar; Stramenopiles; Ochrophyta; PX clade; Phaeophyceae;
OC Ectocarpales; Ectocarpaceae; Ectocarpus.
OX NCBI_TaxID=2880 {ECO:0000313|EMBL:CBJ31166.1, ECO:0000313|Proteomes:UP000002630};
RN [1] {ECO:0000313|EMBL:CBJ31166.1, ECO:0000313|Proteomes:UP000002630}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ec32 / CCAP1310/4 {ECO:0000313|Proteomes:UP000002630};
RX PubMed=20520714; DOI=10.1038/nature09016;
RA Cock J.M., Sterck L., Rouze P., Scornet D., Allen A.E., Amoutzias G.,
RA Anthouard V., Artiguenave F., Aury J.M., Badger J.H., Beszteri B.,
RA Billiau K., Bonnet E., Bothwell J.H., Bowler C., Boyen C., Brownlee C.,
RA Carrano C.J., Charrier B., Cho G.Y., Coelho S.M., Collen J., Corre E.,
RA Da Silva C., Delage L., Delaroque N., Dittami S.M., Doulbeau S., Elias M.,
RA Farnham G., Gachon C.M., Gschloessl B., Heesch S., Jabbari K., Jubin C.,
RA Kawai H., Kimura K., Kloareg B., Kupper F.C., Lang D., Le Bail A.,
RA Leblanc C., Lerouge P., Lohr M., Lopez P.J., Martens C., Maumus F.,
RA Michel G., Miranda-Saavedra D., Morales J., Moreau H., Motomura T.,
RA Nagasato C., Napoli C.A., Nelson D.R., Nyvall-Collen P., Peters A.F.,
RA Pommier C., Potin P., Poulain J., Quesneville H., Read B., Rensing S.A.,
RA Ritter A., Rousvoal S., Samanta M., Samson G., Schroeder D.C., Segurens B.,
RA Strittmatter M., Tonon T., Tregear J.W., Valentin K., von Dassow P.,
RA Yamagishi T., Van de Peer Y., Wincker P.;
RT "The Ectocarpus genome and the independent evolution of multicellularity in
RT brown algae.";
RL Nature 465:617-621(2010).
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DR EMBL; FN648416; CBJ31166.1; -; Genomic_DNA.
DR AlphaFoldDB; D7FSM5; -.
DR STRING; 2880.D7FSM5; -.
DR EnsemblProtists; CBJ31166; CBJ31166; Esi_0236_0043.
DR eggNOG; KOG4424; Eukaryota.
DR InParanoid; D7FSM5; -.
DR OrthoDB; 53554at2759; -.
DR Proteomes; UP000002630; Chromosome LG29.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR12673:SF248; DH DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR12673; FACIOGENITAL DYSPLASIA PROTEIN; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002630}.
FT DOMAIN 2..194
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 221..321
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 326..435
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 449..490
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 521..601
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 629..1002
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1024..1048
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 326..364
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 471..490
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 568..591
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 653..680
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 700..724
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 730..760
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 794..808
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 824..841
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 941..960
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1048 AA; 111835 MW; ECA3256F397747B1 CRC64;
MLTVQVRDEI ISSEETYVKE LRTLVMVFLR PLEKWAAEGM NGLDVPAGSV SEIFSNVAAI
LEFNERFLSD LAGRHGEEVD GRRRGIGTTL RRQSLDMFKP YSVYVKNYPQ SLKTLAACEE
FSEFNAFIRG CEHQDACHGL DLKAYLIQPV QRVPRYRLLI IQLLKHTKES HPDWADLNAA
LETVSSTVTK LNEGARDKER FVRALELQYE FREDFLKPSS HLVKEGFLLK VCNGGPRRYK
FVLFSHMLVY GTEASLRAKL QRDHRKYKVH GRIPLHECLV LDYGSSDSFA IARSSGKSFV
AMAVSAEAKQ AWLDAFEESF AGIKDNAQQD DGNQGQRSLP QQQPTRRGSK NRGAPSSPTS
EANSSRRASE DDWTLALPPA TRQEDDGRVG AGNANSSAGH SAEGGMIGRD GEECPPPLSP
PARPTKPHLG FPSGGATLAQ TVAASMAMPG RWSLPNGGGG GGGGRMSLAS HATSGGGSSP
RSAQSSFSRR AGVQVWVPVH GRTEMHEISL RGLPAGSTSG LFKVQEGGAS NDDLNNNDDD
KYASGDTKGG GDLPPNGPKR KPLATTFPGA RSATTRLAAS TSRQTTRSPS PGRHYEGDWV
GGTVIAAGGG GGTARGTYGG SGGNAAEGVD WRVGGGSEVG ADGSADVDGG RDGGGLARGR
HDSTGLADRA ETEGRGRPRR RLPAMPSAQA VAEMQMLPFS DEGGNSSDSG SNDDDPSSIQ
AVAASWRLTG DRGKFRKMLA KFEAGPRTTP ADEEKGNADE ETQAAAAAGG RRKQAVEPDL
GWGDSVKTSR GEQQTATKRQ RQEEGGRENG ENEDDAEEDN ERFAYISSSV STSSSSLETE
HVNPLALMRD PVCVRPSEML NNPTTPRAFS AATAPSRDAA GANAKGAEGA PPGKKECPSF
PGTRGEEATR SSNSRRSSRF LPRARSWTAK KRRSPQRAGN SDNDDGESNT GGSRSNSPRR
ASAGMLGALQ RSFRDRLKTN RLLSSPPRTT TRKRWSKSDE AEKKGLAGLF LARARGTAAA
AAAAAADGRR NGGCPPDSQQ ATPVSDPE
//
