ID D7FZH6_ECTSI Unreviewed; 4053 AA.
AC D7FZH6;
DT 10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT 10-AUG-2010, sequence version 1.
DT 24-JAN-2024, entry version 52.
DE SubName: Full=WD repeat domain-containing protein, putative {ECO:0000313|EMBL:CBJ49286.1};
GN ORFNames=Esi_0371_0015 {ECO:0000313|EMBL:CBJ49286.1};
OS Ectocarpus siliculosus (Brown alga) (Conferva siliculosa).
OC Eukaryota; Sar; Stramenopiles; Ochrophyta; PX clade; Phaeophyceae;
OC Ectocarpales; Ectocarpaceae; Ectocarpus.
OX NCBI_TaxID=2880 {ECO:0000313|EMBL:CBJ49286.1, ECO:0000313|Proteomes:UP000002630};
RN [1] {ECO:0000313|EMBL:CBJ49286.1, ECO:0000313|Proteomes:UP000002630}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ec32 / CCAP1310/4 {ECO:0000313|Proteomes:UP000002630};
RX PubMed=20520714; DOI=10.1038/nature09016;
RA Cock J.M., Sterck L., Rouze P., Scornet D., Allen A.E., Amoutzias G.,
RA Anthouard V., Artiguenave F., Aury J.M., Badger J.H., Beszteri B.,
RA Billiau K., Bonnet E., Bothwell J.H., Bowler C., Boyen C., Brownlee C.,
RA Carrano C.J., Charrier B., Cho G.Y., Coelho S.M., Collen J., Corre E.,
RA Da Silva C., Delage L., Delaroque N., Dittami S.M., Doulbeau S., Elias M.,
RA Farnham G., Gachon C.M., Gschloessl B., Heesch S., Jabbari K., Jubin C.,
RA Kawai H., Kimura K., Kloareg B., Kupper F.C., Lang D., Le Bail A.,
RA Leblanc C., Lerouge P., Lohr M., Lopez P.J., Martens C., Maumus F.,
RA Michel G., Miranda-Saavedra D., Morales J., Moreau H., Motomura T.,
RA Nagasato C., Napoli C.A., Nelson D.R., Nyvall-Collen P., Peters A.F.,
RA Pommier C., Potin P., Poulain J., Quesneville H., Read B., Rensing S.A.,
RA Ritter A., Rousvoal S., Samanta M., Samson G., Schroeder D.C., Segurens B.,
RA Strittmatter M., Tonon T., Tregear J.W., Valentin K., von Dassow P.,
RA Yamagishi T., Van de Peer Y., Wincker P.;
RT "The Ectocarpus genome and the independent evolution of multicellularity in
RT brown algae.";
RL Nature 465:617-621(2010).
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DR EMBL; FN648566; CBJ49286.1; -; Genomic_DNA.
DR STRING; 2880.D7FZH6; -.
DR EnsemblProtists; CBJ49286; CBJ49286; Esi_0371_0015.
DR eggNOG; KOG0383; Eukaryota.
DR eggNOG; KOG0644; Eukaryota.
DR eggNOG; KOG1633; Eukaryota.
DR InParanoid; D7FZH6; -.
DR OrthoDB; 124870at2759; -.
DR Proteomes; UP000002630; Chromosome LG24.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd04369; Bromodomain; 1.
DR Gene3D; 1.20.920.10; Bromodomain-like; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 2.
DR InterPro; IPR001487; Bromodomain.
DR InterPro; IPR036427; Bromodomain-like_sf.
DR InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR16266:SF17; BRWD3; 1.
DR PANTHER; PTHR16266; WD REPEAT DOMAIN 9; 1.
DR Pfam; PF00439; Bromodomain; 1.
DR Pfam; PF00628; PHD; 1.
DR SMART; SM00297; BROMO; 1.
DR SMART; SM00249; PHD; 2.
DR SUPFAM; SSF47370; Bromodomain; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 2.
DR PROSITE; PS50014; BROMODOMAIN_2; 1.
DR PROSITE; PS01359; ZF_PHD_1; 2.
DR PROSITE; PS50016; ZF_PHD_2; 2.
PE 4: Predicted;
KW Bromodomain {ECO:0000256|PROSITE-ProRule:PRU00035};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000002630};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00146}.
FT DOMAIN 1679..1725
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 3384..3434
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 3800..3870
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT REGION 1..260
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 290..754
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 817..1233
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1253..1350
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1541..1615
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1748..2052
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2287..2504
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2933..2969
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2991..3320
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3439..3470
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3483..3540
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3887..4053
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 2792..2928
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 295..313
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 383..409
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 599..624
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 678..692
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 730..747
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 875..889
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 906..926
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 940..968
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 980..1004
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1021..1037
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1121..1140
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1150..1216
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1301..1318
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1820..1834
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1846..1862
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1863..1903
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2003..2052
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2457..2488
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2934..2952
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3274..3288
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3905..3927
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3997..4053
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4053 AA; 409937 MW; C0FAF5C3EAA6554F CRC64;
MDGDPRDGAV PVDSGSNGLA AGTVAGASPR PDRSEPGSVS PAGFAGLSTD PSVGGSKQHL
GLAVVAQQET KDDEPGDVDG SGNGTQHGNA ELAAAAAAMP LDGKPPPMPA GSRHPQPPSA
DGERSTGDGT PAATDGSPAG VAGLRTSHGA PPPTAPPLPA TPASSSKSGG AMKLGGGASM
GPNISSAPRG MGGRHRHLEG GHGDAAGDSP PAAEASVAAT AGTPASSSAT QGPADDFGDI
LAGGHGPTPT AVASMEAVTE EGPDACVSMA SVARQTSPSP SLMEVDSLLA FPRGYGTPSP
PPPAAPVPPP AGRPSETAME AEEEMLLPRQ PPTAGGTLSA SRDEPGAWTG EEGGGGAACP
RDRALLSQLP TAAPPACSES DRAPQESGGS KESLTLPQGV RSSAEPIAAR SSSPLHPPGP
GGATGKVLDD FASPVAPVAA EQGGAAIGDR PTGRASVATP QGWLERDAAK RRPVDATPRV
GAGAAGSDRT RSEAMDAVKS VGPPSLADSP VSRAGKGQED EAVESRNKMV AQGVAAAGSE
PPLPPPQLAP SSAEARSLSP GEVTTPRAAL DPVEGRVDAR LGVEQAPSRG GGGVQAMDVD
GPQQQQQQPS SAGMSGQQDR GFRSLNGEVY TGAFGSRASE GSAGGGDGGA GDEATDGAAG
GVAGDVPGGS RPGQGRDPPG RSSEEKEGAG EGPVGDVPRG VAGRRGRDAQ PLSGLAPGVV
LPALEGRTSS EAAPAQTSSS SPAIPTPFEG NSVGMLAAGA ANPCDFSGQS LADQLLADDP
PEMMVVGEGF PASERTALVG GGAPGASGGE AAVNAGGVSA LGRRTNGDEA LAGPRRSSTA
AEPAGTAALD RQRVGLKEAG SRREGGRNGR GLSLQAVAQG PTASSSGAGL SPRFGGGAIG
VNHFSDAPVA NTSYNSAQSF GGSGSTSPRG GAGLHAAGAG AATSSSSAIT PFPSASAPAS
SSSSLANGGP MHRAVAAAGN SFATHTSRTL PPPLSMTPGV SAGSSPRQAP AGWRSGPPGG
TSNDARVQQN SWLSNDGANG GGGGGISPRG FGQQPVTRGS HHQLQPEMPP PAPPVAAPPE
LDGGDGQAQE AAPAASGDSL SGPGAAACAG ADDMDVDEEE ARRDGTERSG DSRKQSSSSD
TAEVDRSGGG GGASEKEGEA AEERLQGEDD GRDHGVEEEK GGEREESDEA ARRKAQGEKE
LAEKEAASKA EAGAKRKARA AAAAAAEAAE AAAEKRARRL RVFLVLKRLR EDAEERKRSG
RLAQPRGGGA GAGAGAAAAL DDPAWAAEED PFQEQEPVIA VPRLRGHEGK KAKARQDAGR
SGEGAGGGPA EKGAGASGCP PLGQRRLQRR LGCARRHAAL AQHPGGAGLR LSTLLKADAP
AEDPSRGGCA GGSSWLGARL ARMRRVEGEE WAAWQRRVGE EEASNPGEAA GPPLPFGFVP
RLVHRALGAY ALIRTFSRPF RLTPASSVSF LRALSLRLRT PLLDAIHCEL LRRVLCLLRG
RAGNWAKSSA AQRELDWKYL DQVTWPAYFV EFVQTMEEQR QREDAKAAAE AAAADAEQHG
MMSVSGEEEE DASLSGDSDD FSGKRRRRRR RRRRGGGNGG GSGSEEEEEE EEEEMDSLET
LCLAFQAGEH HLLPLEMKVQ ALEYLVDRAM ECPWFEKEID NRVRTPPEAF VVDADDGKVF
DCVICGQVGN LLCCDNCPRA YHPRCVGGKQ GIDSVNWSCW ECLIEDSARD GVRVPRVSTS
MGPVWVIGGY VFRPTPPPPP SSRKKDGAGG GGGGGKSWEA AAEEAEEAEA AAIVKAAEQA
AEGNGSPEDP PGEAGWQDED GVSESSSPSA TTTRRAPAAG GDEGSGSEGK DSDSDDDGPS
TARQVRVTRS RLKATTGEPE ASATTKPSSS SSSSASSSGS EDSESEASEA EKYAAKKALS
RKAPTRVCRS RGSPPPKPAP SDVDEQGVED AAVVASADKK SRAGKGRASA AGRSASDDDD
DEAGGEAAEE ESPAGGGARD PGEEASQEAE AYARAAAERK AKAEARTKAA AEAKAAKETE
ARRKREARQA AERAAAEAAA EAKAKARALL IASSNPLEYV NRYAKAVPCP GMPAHKEAAP
PLELSQESHF WHAWPLGAVG VPHPLLPGDP VANPAEGEGL VACAHLEPVA RLLLQLEKSF
GGLLFGTQWT SAWGLGGQWP MEVRAAGSVQ ALGRLAQELV EALPARVFRE SWQTPYELKV
SRAYKTEVEA AKAAKAAREA AAEAXXXXXX XXXXXXXXXX XXXXXEREGA AAVKAAAAAA
AAAEARAREE GGAADRNQTD TTGAQAGTWM ANGVTFDDPS PPGSSVPGRR GSGSGLPPQP
SAEPSPTAAE AAAGGSSGAP PADADSAEYR SPKKQRRRSS RPSVPPVELV VSPASMSPLR
SSRGKRKASM GGGRESFGVG TGGGGAGGGE DGDEDAVVPG DASMKSRAGP QQDVGRGVRP
DARRHGGGQG QREGRREQHA RELGVGETLL RGRRFFPPTS RKQPPARLAR AMARRGTHRP
IPGFCYVSPA GTSSAAVDGA KVPVSALWHA RVARCRSAAE LAVHLRSLQV VIDQDLVDQA
TASGGLGVRA ARGGGGGGGG EDQIHVVDER WGSAVGEVEV LLRIWAAGRR SREREIWVRV
SELRPRALLL WVEWRSLAKR EAELAEVRRR QGRRQREEKE KHERAQQVVR HRQARAEHFK
MAFYSILKAH ETAVAGLLEE AMAVGAEAPD ALRLGQARKG AVEKLTANYV RRQETSGPPD
SEKMRWGAMV PRLHDQVMAP LIEVEQNMHA SLRRKVEDAA RARLQMQMAR EQEAARQREM
QARQQEQNRI WQAAAREREE QRRRQAEQRA AAREAKRLEK LRVREELKDM RVEARSEREK
ALEMQLRRVK VAQTQAVEAQ LRQALNSLQR HEIEYRRVLA LLKEAEKRGD VSSRATLKQQ
YPSNNNTADL ASRLLGEDQE GDSPDELVDG TAAAAAAAAV AVAAAPTVGV LGTSPWGAAP
LPGGGAGNPR GGGTSGTGGG GGGGGGGQAR PGAKKAAGKK TPKPKTPASK AGASKAAGAA
KAGGAKSGAG GGAAKAGASS KTGAAAAAAA SKGSSAASKA SKAAAAGKAG AGAKASSSKS
PSAAGAGGAA PKGPGSKSSS AGPPKPSGGG GKAAGSKAGQ QAGAKASSAG GSGKASKAKA
AGSKASATPN ASSAAAAATA GGGGGGGGGG GASAPAKGSS AAASKTPGSK APGSKAPGSK
APGSKGPGSK APASKAPASK AAAKAAAGAA GSKTGAATNK SSSKSKKAAA TPALGPRAQP
GMRPPGHFSP ANGFGGPAAA GGGVASPFAQ KAAAMPAMPA GTGGAFQPGA AAAVVSATGG
AGAPVAGGGA AAAAAAGGGG GGGEVYCVCR TADVTGTMLE CDFCQDWFHV RCVGLTEQDC
DRFSKYACPL CTKNKGKKST LSKKKRKVPP NNNPAAAAAH PSSLLAAGSG GAGAGAPAAV
GGGDGYAALP AQKNKPRAPG GGGGGAGGVG ARSALAGGGG APQSAPGGGG GRGTIEAMPP
VPLADKSVLL RTRRDWLSNS APNSAGPYVP QEGDEVFFFP AGYAAFSEKH PDPREHLRST
SHAFRKVDRG GVACRVARVD FELPARGDDS FDPPVVAAVV TLMPASGSMG GEHEVSMRPS
DRADFLVPRR KVMQALNEGY RPGDTVSVRY SEGQSYEGRI LVIDDGSNSG GGPGFSRPQP
RPWWEGVTVR WEAGGTGTVS AWELSWPKHV LPLVKQRRLD SGLHEDPAAA WARQAGAERG
LLSSEQCTAA LASLERVLRQ QRDVFVAFMD PVTDEIAPNY SMEIALPIHL GLIQQRLQRK
YYRRAEGVFA DLRLLETNCR TYNPAGSLIV DQCRAAMNMA EGALRNSLRS SGGVGVPRSG
GAAAGKGSSS GSPAGQPSSS KKKKKSTTGG GGSGGGGDRR AGAGGDRGGG GTRHPAFAAA
APAAPAAPAG GSSSSAGGAA ARGGGGGGEG GSTFSRAPTF PAPTNAAGNN TSSVGPRPQF
KDNTASSRPQ YGNDVSGGGE QGTNKQLIYS RCE
//
