ID   D7GW05_9FIRM            Unreviewed;      1254 AA.
AC   D7GW05;
DT   10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT   10-AUG-2010, sequence version 1.
DT   24-JAN-2024, entry version 50.
DE   SubName: Full=Phosphoribosylformylglycinamidine synthase {ECO:0000313|EMBL:CBL41997.1};
DE            EC=6.3.5.3 {ECO:0000313|EMBL:CBL41997.1};
GN   ORFNames=CK3_24420 {ECO:0000313|EMBL:CBL41997.1};
OS   butyrate-producing bacterium SS3/4.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales.
OX   NCBI_TaxID=245014 {ECO:0000313|EMBL:CBL41997.1, ECO:0000313|Proteomes:UP000008961};
RN   [1] {ECO:0000313|EMBL:CBL41997.1, ECO:0000313|Proteomes:UP000008961}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SS3/4 {ECO:0000313|EMBL:CBL41997.1,
RC   ECO:0000313|Proteomes:UP000008961};
RG   metaHIT consortium -- http://www.metahit.eu/;
RA   Pajon A., Turner K., Parkhill J., Duncan S., Flint H.;
RT   "The genome sequence of Clostridiales sp. SS3/4.";
RL   Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:CBL41997.1, ECO:0000313|Proteomes:UP000008961}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SS3/4 {ECO:0000313|EMBL:CBL41997.1,
RC   ECO:0000313|Proteomes:UP000008961};
RA   Pajon A.;
RL   Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; FP929062; CBL41997.1; -; Genomic_DNA.
DR   AlphaFoldDB; D7GW05; -.
DR   KEGG; bprs:CK3_24420; -.
DR   PATRIC; fig|245014.3.peg.1034; -.
DR   HOGENOM; CLU_003100_2_0_9; -.
DR   BioCyc; BBAC245014:G1314-2104-MONOMER; -.
DR   Proteomes; UP000008961; Chromosome.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004642; F:phosphoribosylformylglycinamidine synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006164; P:purine nucleotide biosynthetic process; IEA:UniProtKB-KW.
DR   CDD; cd02203; PurL_repeat1; 1.
DR   CDD; cd02204; PurL_repeat2; 1.
DR   Gene3D; 3.40.50.880; -; 1.
DR   Gene3D; 3.90.650.10; PurM-like C-terminal domain; 2.
DR   Gene3D; 3.30.1330.10; PurM-like, N-terminal domain; 2.
DR   InterPro; IPR029062; Class_I_gatase-like.
DR   InterPro; IPR010141; FGAM_synthase.
DR   InterPro; IPR041609; PurL_linker.
DR   InterPro; IPR010918; PurM-like_C_dom.
DR   InterPro; IPR036676; PurM-like_C_sf.
DR   InterPro; IPR036921; PurM-like_N_sf.
DR   NCBIfam; TIGR01857; FGAM-synthase; 1.
DR   PANTHER; PTHR10099; PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE; 1.
DR   PANTHER; PTHR10099:SF1; PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE; 1.
DR   Pfam; PF02769; AIRS_C; 1.
DR   Pfam; PF18072; FGAR-AT_linker; 1.
DR   Pfam; PF13507; GATase_5; 1.
DR   SMART; SM01211; GATase_5; 1.
DR   SUPFAM; SSF52317; Class I glutamine amidotransferase-like; 1.
DR   SUPFAM; SSF56042; PurM C-terminal domain-like; 2.
DR   SUPFAM; SSF55326; PurM N-terminal domain-like; 2.
PE   4: Predicted;
KW   Ligase {ECO:0000313|EMBL:CBL41997.1};
KW   Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Purine biosynthesis {ECO:0000256|ARBA:ARBA00022755}.
FT   DOMAIN          179..228
FT                   /note="Phosphoribosylformylglycinamidine synthase linker"
FT                   /evidence="ECO:0000259|Pfam:PF18072"
FT   DOMAIN          442..593
FT                   /note="PurM-like C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF02769"
SQ   SEQUENCE   1254 AA;  138744 MW;  2FE8F4ED74C840F7 CRC64;
     MSVKRVFVEK KPEYAIKARE LREEIESYLD ITGVTGVRVL VRYDIENISE DVYKEALGTI
     FSEPPVDDVF EETFPHSADD VVFSVEYLPG QFDQRADSAE QCVKLLNENE EPVIRSAMTY
     VISGKLSAEE TAAIKSFCIN PVDSREASEE IPETLVTVFD VPEDVAVFDG FKDMDEAALK
     KLYSSLNLAM TFKDFLHIQN YYKNEEHRDP SVTEIRVLDT YWSDHCRHTT FSTELKNVTF
     TEGDYKKPIE DTYNQYLADH KEIYKGRDDK FVCLMDLAIM GMKKLRKEGK LEDLEVSDEI
     NACSIVVPVE IDGKTEEWLV NFKNETHNHP TEIEPFGGAA TCLGGAIRDP LSGRTYVYQA
     MRITGAADPT KPLNQTLKGK LPQRKIVTEA AHGYSSYGNQ IGLATGYVKE LYHPGYVAKR
     MEIGAVMAAA PRKNVIRETS DPGDVIILLG GRTGRDGIGG ATGSSKVHTE ASIEVCGAEV
     QKGNAPTERK IQRMFRRPEV SKLIKKCNDF GAGGVSVAIG ELADGLLIDL DKVPKKYAGL
     DGTELAISES QERMAVVVDP KDVDTFLGYA KEENLEAVTV ATVTESPRLV LTWRGKTIVD
     LSRAFLDTNG AHQETDVTLE VPNHEGTPFE KKEVGDVKEK WLKMLGSLNV CSQKGLVEMF
     DSSIGASTVM MPYGGKYQQT EIQTMVAKLP VLEGKCDAVT MMSYGFDPYL SSWSPYHGAI
     YAVLTSVAKI AAAGGDYRKI RFTFQEYFRR MSSEPARWSQ PFAALLGAYN AQLGFGLPSI
     GGKDSMSGTF DEESGKEIDV PPTLVSFAVD VASAKNMISP EFKKAGNKIV VFEIEKDSYD
     LPDYARIMDG YDKLHEDIKA GRVISAYAAE ANGIAEAVSK MAFGNHLGVK IEHDVDPRDF
     FAPAWGNIVC EVPADKVGEL QMSYRVIGEV TDKAAFEYGN VSVTLDEALK TWDAALEDVF
     PTESDVRKEE VKNEVFKAEN VVICNHKIGT PTVFIPVFPG TNCEYDSTKA FERAGAKVIT
     KVFKNMSAED IRDSVEVYRK SIEQSQIVMF PGGFSAGDEP EGSAKFFATA FRNEVLKDEI
     MKLLNERDGL MLGICNGFQA LIKLGLVPEG KIVEQKPDSP TLTYNTIGRH VSKMVNLKVV
     SNKSPWLAGA ELGGIYTNPV SHGEGRFVAP KEWIDKLFTN GQVATQYVDL NGVPTMDEYW
     NPNGSFMAIE GITSPDGRVY GKMGHAERRG DYVAKNITGE QDLKLFESGV KYFK
//