ID D7IG97_9BACE Unreviewed; 637 AA.
AC D7IG97;
DT 10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT 10-AUG-2010, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE SubName: Full=Arabinan endo-1,5-alpha-L-arabinosidase A {ECO:0000313|EMBL:EFI03190.1};
GN ORFNames=HMPREF9007_03395 {ECO:0000313|EMBL:EFI03190.1};
OS Bacteroides sp. 1_1_14.
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC Bacteroides.
OX NCBI_TaxID=469585 {ECO:0000313|EMBL:EFI03190.1, ECO:0000313|Proteomes:UP000003951};
RN [1] {ECO:0000313|EMBL:EFI03190.1, ECO:0000313|Proteomes:UP000003951}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1_1_14 {ECO:0000313|EMBL:EFI03190.1,
RC ECO:0000313|Proteomes:UP000003951};
RG The Broad Institute Genome Sequencing Platform;
RA Ward D., Earl A., Feldgarden M., Gevers D., Young S.K., Zeng Q.,
RA Koehrsen M., Alvarado L., Berlin A., Bochicchio J., Borenstein D.,
RA Chapman S.B., Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J.,
RA Griggs A., Gujja S., Heilman E., Heiman D., Hepburn T., Howarth C., Jen D.,
RA Larson L., Mehta T., Park D., Pearson M., Roberts A., Saif S., Shea T.,
RA Shenoy N., Sisk P., Stolte C., Sykes S., Thomson T., Walk T., White J.,
RA Yandava C., Strauss J., Daigneault M., McDonald J., Ambrose C.E.,
RA Allen-Vercoe E., Haas B., Nusbaum C., Birren B.;
RT "The Genome Sequence of Bacteroides sp. strain 1_1_14.";
RL Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Glycan metabolism; L-arabinan degradation.
CC {ECO:0000256|ARBA:ARBA00004834}.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 43 family.
CC {ECO:0000256|ARBA:ARBA00009865}.
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DR EMBL; GG774708; EFI03190.1; -; Genomic_DNA.
DR AlphaFoldDB; D7IG97; -.
DR HOGENOM; CLU_440676_0_0_10; -.
DR Proteomes; UP000003951; Unassembled WGS sequence.
DR GO; GO:0004553; F:hydrolase activity, hydrolyzing O-glycosyl compounds; IEA:InterPro.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:UniProtKB-KW.
DR CDD; cd18616; GH43_ABN-like; 1.
DR CDD; cd18827; GH43_XlnD-like; 1.
DR InterPro; IPR006710; Glyco_hydro_43.
DR InterPro; IPR023296; Glyco_hydro_beta-prop_sf.
DR PANTHER; PTHR43301; ARABINAN ENDO-1,5-ALPHA-L-ARABINOSIDASE; 1.
DR PANTHER; PTHR43301:SF3; ARABINOSIDASE-RELATED; 1.
DR Pfam; PF04616; Glyco_hydro_43; 2.
DR SUPFAM; SSF75005; Arabinanase/levansucrase/invertase; 2.
PE 3: Inferred from homology;
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..637
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003097553"
FT ACT_SITE 348
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR606710-1"
FT ACT_SITE 509
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR606710-1"
FT SITE 462
FT /note="Important for catalytic activity, responsible for
FT pKa modulation of the active site Glu and correct
FT orientation of both the proton donor and substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR606710-2"
SQ SEQUENCE 637 AA; 71563 MW; 1B7263003749182B CRC64;
MKLRHLFLFC VICCSVSISA QNKSKLPKTS GNPIFPGWYA DPEGIVFGDE YWIYPTYSAA
YDDQIFMDAF SSKDLVNWTK HPKVLSKENI SWLRRALWAP AVIHANDKYY FFFGANDIQN
NNELGGIGVA VADNPAGPFK DALGKPLIDK IVNGAQPIDQ FVFKDDDGQY YMYYGGWGHC
NMVKMAPDLL SIVPFEDGTI YKEVTPQNYV EGPFMLKHNG KYYFMWSEGG WGGPDYSVAY
AIADSPFGPF ERVGKILQQD TNIATGAGHH SVVKGPGADE WYIIYHRRPL GETAANSRAT
CIDRMYFNKD GKIEPVRMTF EGVGASPLAT PVRAKTYANP VINFSLPDPT IIKGDDEYYY
LYATESIKNV PIHRSRDLVN WYYVGTAFTD ATRPNFEPKG RIWAPDINKI GDKYVMYYSM
STWGGEWTCG IGIATADKPE GPFTDLGKLF RSNEINIQNC IDPFYIEDNG KKYLFWGSFH
GIYGTELTED GLSLKKGAPI EQIAGTAYEG TYIHKRGGYY YLFASIGRCC EGLKSTYTTV
VGRSKNLFGP YVDKKGRSMS DNHHEILIQK NKAFVGPGHN SELVTDKKGN DWMFYHAVSV
ANPEGRVLMM DRVQWKGGWP FVKGAVPSLE TAAPDFR
//
