ID D7K2X4_9BACE Unreviewed; 774 AA.
AC D7K2X4;
DT 10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT 10-AUG-2010, sequence version 1.
DT 24-JAN-2024, entry version 46.
DE RecName: Full=beta-N-acetylhexosaminidase {ECO:0000256|ARBA:ARBA00012663};
DE EC=3.2.1.52 {ECO:0000256|ARBA:ARBA00012663};
GN ORFNames=HMPREF9010_02311 {ECO:0000313|EMBL:EFI41205.1};
OS Bacteroides sp. 3_1_23.
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC Bacteroides.
OX NCBI_TaxID=457390 {ECO:0000313|EMBL:EFI41205.1, ECO:0000313|Proteomes:UP000003808};
RN [1] {ECO:0000313|EMBL:EFI41205.1, ECO:0000313|Proteomes:UP000003808}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=3_1_23 {ECO:0000313|EMBL:EFI41205.1,
RC ECO:0000313|Proteomes:UP000003808};
RG The Broad Institute Genome Sequencing Platform;
RA Ward D., Earl A., Feldgarden M., Gevers D., Young S.K., Zeng Q.,
RA Koehrsen M., Alvarado L., Berlin A., Bochicchio J., Borenstein D.,
RA Chapman S.B., Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J.,
RA Griggs A., Gujja S., Heilman E., Heiman D., Hepburn T., Howarth C., Jen D.,
RA Larson L., Mehta T., Park D., Pearson M., Roberts A., Saif S., Shea T.,
RA Shenoy N., Sisk P., Stolte C., Sykes S., Thomson T., Walk T., White J.,
RA Yandava C., Strauss J., Daigneault M., McDonald J., Ambrose C.E.,
RA Allen-Vercoe E., Haas B., Nusbaum C., Birren B.;
RT "The Genome Sequence of Bacteroides sp. strain 3_1_23.";
RL Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 20 family.
CC {ECO:0000256|ARBA:ARBA00006285}.
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DR EMBL; GG774949; EFI41205.1; -; Genomic_DNA.
DR RefSeq; WP_008648809.1; NZ_GG774949.1.
DR AlphaFoldDB; D7K2X4; -.
DR HOGENOM; CLU_007082_5_0_10; -.
DR Proteomes; UP000003808; Unassembled WGS sequence.
DR GO; GO:0004563; F:beta-N-acetylhexosaminidase activity; IEA:UniProtKB-EC.
DR GO; GO:0102148; F:N-acetyl-beta-D-galactosaminidase activity; IEA:UniProtKB-EC.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR CDD; cd06563; GH20_chitobiase-like; 1.
DR Gene3D; 3.30.379.10; Chitobiase/beta-hexosaminidase domain 2-like; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR InterPro; IPR025705; Beta_hexosaminidase_sua/sub.
DR InterPro; IPR000421; FA58C.
DR InterPro; IPR026876; Fn3_assoc_repeat.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR015883; Glyco_hydro_20_cat.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR InterPro; IPR029018; Hex-like_dom2.
DR InterPro; IPR015882; HEX_bac_N.
DR PANTHER; PTHR22600; BETA-HEXOSAMINIDASE; 1.
DR PANTHER; PTHR22600:SF21; BETA-HEXOSAMINIDASE A; 1.
DR Pfam; PF00754; F5_F8_type_C; 1.
DR Pfam; PF13287; Fn3_assoc; 1.
DR Pfam; PF00728; Glyco_hydro_20; 1.
DR Pfam; PF02838; Glyco_hydro_20b; 1.
DR PRINTS; PR00738; GLHYDRLASE20.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR SUPFAM; SSF55545; beta-N-acetylhexosaminidase-like domain; 1.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..774
FT /note="beta-N-acetylhexosaminidase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003100322"
FT DOMAIN 29..157
FT /note="Beta-hexosaminidase bacterial type N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02838"
FT DOMAIN 161..515
FT /note="Glycoside hydrolase family 20 catalytic"
FT /evidence="ECO:0000259|Pfam:PF00728"
FT DOMAIN 647..749
FT /note="F5/8 type C"
FT /evidence="ECO:0000259|Pfam:PF00754"
FT ACT_SITE 344
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR625705-1"
SQ SEQUENCE 774 AA; 88020 MW; 6B2627A8BB4A103E CRC64;
MKKYILIILI LLSPLTAFLQ ADNLTSPLIS IVPRPTQIVP GRGNFTFSAQ TVFAVENQEQ
AVIARNFIDL FTHAAGITPA LNVGREEGQV RFVTDSSLKS EAYLLEITPE QILIKASDTK
GFFYALQSIR QLLPAAIESE QPVRNVDWRV PAMTVQDEPR FGFRGLLLDP VRCFIPKKNV
LRIIDCMAML KINKLHFHLT DDNGWRIEIK KYPRLTEIGA WRVDRTDVPF HSRRNPERGE
PTPIGGFYTQ EDIREIVAYA ADRQIEVIPE IDVPAHSNSA LAAYPQLACP VVKDFVGVLP
GLGGRNSEII YCAGNDSVFT FLQDVFDEIL ELFPSRYIHV GGDEARKTNW EKCPLCQKRM
KKQRLANEED LQGYFMKRIS DYLRKKGREV IGWDELTNSS FLPEESIILG WQGMGTAALK
AAEKGHRFIM TPARVLYLIR YQGPQWFEPV TYFGNNTLKD VFDYEPVQKD WKPEYESLLM
GVQACMWTEF CNKPEDVDYL LFPRLAALAE VAWTPAGTKD WSGFLKRMDA YNAHIAEKGI
VYARSMYNIQ QTVTPVDGHL EVNLECIRPD VEIHYTLNGS NPAMSSHRYD GPIRVTKTQM
VKAATFMNGK QMGETLELQL TWNKATAKPL LGNKKNEMLL VNGLRGSLKY TDFEWCNWNQ
NDSISFTIDL QGREILNKFT IGCITNYGMG AHKPKMIRVE VSDDNRTYHT MGELNFSPKE
IYLEGTFRND YSIDMGGVSA RYVRVTAEGA GICPDEHVCP GQEARVYFDE VIIE
//
