ID D7KBH7_ARALL Unreviewed; 521 AA.
AC D7KBH7;
DT 10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT 10-AUG-2010, sequence version 1.
DT 24-JAN-2024, entry version 49.
DE SubName: Full=Glucose-methanol-choline oxidoreductase family protein {ECO:0000313|EMBL:EFH66301.1};
GN ORFNames=ARALYDRAFT_334713 {ECO:0000313|EMBL:EFH66301.1};
OS Arabidopsis lyrata subsp. lyrata (Lyre-leaved rock-cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=81972 {ECO:0000313|Proteomes:UP000008694};
RN [1] {ECO:0000313|Proteomes:UP000008694}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. MN47 {ECO:0000313|Proteomes:UP000008694};
RX PubMed=21478890; DOI=10.1038/ng.807;
RA Hu T.T., Pattyn P., Bakker E.G., Cao J., Cheng J.-F., Clark R.M.,
RA Fahlgren N., Fawcett J.A., Grimwood J., Gundlach H., Haberer G.,
RA Hollister J.D., Ossowski S., Ottilar R.P., Salamov A.A., Schneeberger K.,
RA Spannagl M., Wang X., Yang L., Nasrallah M.E., Bergelson J.,
RA Carrington J.C., Gaut B.S., Schmutz J., Mayer K.F.X., Van de Peer Y.,
RA Grigoriev I.V., Nordborg M., Weigel D., Guo Y.-L.;
RT "The Arabidopsis lyrata genome sequence and the basis of rapid genome size
RT change.";
RL Nat. Genet. 43:476-481(2011).
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974,
CC ECO:0000256|PIRSR:PIRSR000137-2};
CC -!- SIMILARITY: Belongs to the GMC oxidoreductase family.
CC {ECO:0000256|ARBA:ARBA00010790}.
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DR EMBL; GL348713; EFH66301.1; -; Genomic_DNA.
DR RefSeq; XP_002890042.1; XM_002889996.1.
DR AlphaFoldDB; D7KBH7; -.
DR STRING; 81972.D7KBH7; -.
DR EnsemblPlants; fgenesh1_pg.C_scaffold_1001278; fgenesh1_pg.C_scaffold_1001278; fgenesh1_pg.C_scaffold_1001278.
DR GeneID; 9328856; -.
DR Gramene; fgenesh1_pg.C_scaffold_1001278; fgenesh1_pg.C_scaffold_1001278; fgenesh1_pg.C_scaffold_1001278.
DR KEGG; aly:9328856; -.
DR eggNOG; KOG1238; Eukaryota.
DR HOGENOM; CLU_026750_0_0_1; -.
DR OrthoDB; 52047at2759; -.
DR Proteomes; UP000008694; Unassembled WGS sequence.
DR GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR GO; GO:0016614; F:oxidoreductase activity, acting on CH-OH group of donors; IEA:InterPro.
DR Gene3D; 3.30.410.40; -; 1.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR012132; GMC_OxRdtase.
DR InterPro; IPR000172; GMC_OxRdtase_N.
DR InterPro; IPR007867; GMC_OxRtase_C.
DR PANTHER; PTHR45968:SF19; GLUCOSE-METHANOL-CHOLINE (GMC) OXIDOREDUCTASE FAMILY PROTEIN; 1.
DR PANTHER; PTHR45968; OSJNBA0019K04.7 PROTEIN; 1.
DR Pfam; PF05199; GMC_oxred_C; 1.
DR Pfam; PF00732; GMC_oxred_N; 1.
DR PIRSF; PIRSF000137; Alcohol_oxidase; 2.
DR SUPFAM; SSF54373; FAD-linked reductases, C-terminal domain; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR PROSITE; PS00624; GMC_OXRED_2; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR000137-3};
KW FAD {ECO:0000256|PIRSR:PIRSR000137-2};
KW Flavoprotein {ECO:0000256|PIRSR:PIRSR000137-2};
KW Reference proteome {ECO:0000313|Proteomes:UP000008694};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..521
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003100769"
FT DOMAIN 269..283
FT /note="Glucose-methanol-choline oxidoreductase N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS00624"
FT BINDING 65..66
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR000137-2"
FT BINDING 112
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR000137-2"
FT BINDING 225
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR000137-2"
FT BINDING 443
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000137-2"
FT BINDING 473
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR000137-2"
FT DISULFID 397..436
FT /evidence="ECO:0000256|PIRSR:PIRSR000137-3"
SQ SEQUENCE 521 AA; 57788 MW; EAFE6D363BF5963F CRC64;
MSHFVFLFII FMFINLSEGA QMPYMTTDPK EVSGKSFDYI VVGGGTAGCS LAATLSEKYS
VLVIERGGSP FGDPLVEERR YFGYSLLNTD EYSSVAQSFT SVDGIENYRG RVLGGSSAIN
GGFYSRASDE FVKKTGWDKD LVQDCYKWVE SKVVFMPELT QWQSVVQFGF LEAGFYPYNG
YSLEHTQGTK IGGSIYDQCG KRHTSADLLG FGKPNYITVL LNATVQSIIF DANKTRAVGV
RFMESDENSN KSYKAHVEKH RGEVILTAGA LGSPQILLLS GIGPENHLKD FDIPVIVNLK
EVGRKMSDNP AISLLVDRFS QNRTLEPPQV AAIAEGYKFI LESAVLPTDI TTTRISIAAK
IAFPKSKGRL KLNSTNPMEN PAVKFNYLKN KEDLDACQEM VLHLQHVARS ECVTFFLGTQ
AQDKLVAGDE DLKNFCKQNV RTYYHYHGGC IVGPVVDEAY KVNGVKRLRV IDGSTFEESP
GTNPMATVLM LGRYQGIKIL KEREEQENMF LSPQGSPQPQ P
//
