ID D7KMI6_ARALL Unreviewed; 345 AA.
AC D7KMI6;
DT 10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT 10-AUG-2010, sequence version 1.
DT 24-JAN-2024, entry version 55.
DE SubName: Full=Oxidoreductase {ECO:0000313|EMBL:EFH68915.1};
GN ORFNames=ARALYDRAFT_888493 {ECO:0000313|EMBL:EFH68915.1};
OS Arabidopsis lyrata subsp. lyrata (Lyre-leaved rock-cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=81972 {ECO:0000313|Proteomes:UP000008694};
RN [1] {ECO:0000313|Proteomes:UP000008694}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. MN47 {ECO:0000313|Proteomes:UP000008694};
RX PubMed=21478890; DOI=10.1038/ng.807;
RA Hu T.T., Pattyn P., Bakker E.G., Cao J., Cheng J.-F., Clark R.M.,
RA Fahlgren N., Fawcett J.A., Grimwood J., Gundlach H., Haberer G.,
RA Hollister J.D., Ossowski S., Ottilar R.P., Salamov A.A., Schneeberger K.,
RA Spannagl M., Wang X., Yang L., Nasrallah M.E., Bergelson J.,
RA Carrington J.C., Gaut B.S., Schmutz J., Mayer K.F.X., Van de Peer Y.,
RA Grigoriev I.V., Nordborg M., Weigel D., Guo Y.-L.;
RT "The Arabidopsis lyrata genome sequence and the basis of rapid genome size
RT change.";
RL Nat. Genet. 43:476-481(2011).
CC -!- COFACTOR:
CC Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
CC Evidence={ECO:0000256|PIRSR:PIRSR604574-2};
CC Note=Binds 1 Fe(2+) ion per subunit. {ECO:0000256|PIRSR:PIRSR604574-2};
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DR EMBL; GL348713; EFH68915.1; -; Genomic_DNA.
DR RefSeq; XP_002892656.1; XM_002892610.1.
DR AlphaFoldDB; D7KMI6; -.
DR SMR; D7KMI6; -.
DR STRING; 81972.D7KMI6; -.
DR EnsemblPlants; scaffold_101287.1; scaffold_101287.1; scaffold_101287.1.
DR GeneID; 9325960; -.
DR Gramene; scaffold_101287.1; scaffold_101287.1; scaffold_101287.1.
DR KEGG; aly:9325960; -.
DR eggNOG; KOG2731; Eukaryota.
DR HOGENOM; CLU_029471_2_0_1; -.
DR OrthoDB; 47845at2759; -.
DR Proteomes; UP000008694; Unassembled WGS sequence.
DR GO; GO:0051213; F:dioxygenase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR Gene3D; 2.60.120.590; Alpha-ketoglutarate-dependent dioxygenase AlkB-like; 1.
DR InterPro; IPR004574; Alkb.
DR InterPro; IPR027450; AlkB-like.
DR InterPro; IPR037151; AlkB-like_sf.
DR InterPro; IPR005123; Oxoglu/Fe-dep_dioxygenase.
DR PANTHER; PTHR16557; ALKYLATED DNA REPAIR PROTEIN ALKB-RELATED; 1.
DR PANTHER; PTHR16557:SF11; ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB; 1.
DR Pfam; PF13532; 2OG-FeII_Oxy_2; 1.
DR SUPFAM; SSF51197; Clavaminate synthase-like; 1.
DR PROSITE; PS51471; FE2OG_OXY; 1.
PE 4: Predicted;
KW Dioxygenase {ECO:0000256|ARBA:ARBA00022964};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Iron {ECO:0000256|PIRSR:PIRSR604574-2};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR604574-2};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000008694}.
FT DOMAIN 225..345
FT /note="Fe2OG dioxygenase"
FT /evidence="ECO:0000259|PROSITE:PS51471"
FT BINDING 243
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PIRSR:PIRSR604574-2"
FT BINDING 245
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PIRSR:PIRSR604574-2"
FT BINDING 299
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PIRSR:PIRSR604574-2"
SQ SEQUENCE 345 AA; 39046 MW; DF942861C92354C9 CRC64;
MYESANVSDD ADRTAFRRAE KKYKLYYEKD SKFSRRKKLP KPIDLSELLD FKLISQDFNN
NGVLPDGIRV SKVDSSPVFC IENRPGFYFI PGALSLEEQC KWIKESLTNF PQPPNRTNHN
AIYGPIADLF DSAKDNKVLV QEDLTNNKWK FYEEDDIAKA KQSSCKSVSA SVLLRKLRWS
TLGLQFDWSK RNYDVSLPHN NIPDALCQLA KTHAAIAMPD GEEFRPEGAI VNYFGIGDTL
GGHLDDMEAD WSKPIVSMSL GCKAIFLLGG KSKDDPPHAM YLRSGDVVLM AGEARECFHG
VPRIFTDEKN AEIGALESEL SHESGHFFTE YIKTSRININ IRQVF
//
