ID D7KNW0_ARALL Unreviewed; 900 AA.
AC D7KNW0;
DT 10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT 10-AUG-2010, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN ORFNames=ARALYDRAFT_892639 {ECO:0000313|EMBL:EFH70820.1};
OS Arabidopsis lyrata subsp. lyrata (Lyre-leaved rock-cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=81972 {ECO:0000313|Proteomes:UP000008694};
RN [1] {ECO:0000313|Proteomes:UP000008694}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. MN47 {ECO:0000313|Proteomes:UP000008694};
RX PubMed=21478890; DOI=10.1038/ng.807;
RA Hu T.T., Pattyn P., Bakker E.G., Cao J., Cheng J.-F., Clark R.M.,
RA Fahlgren N., Fawcett J.A., Grimwood J., Gundlach H., Haberer G.,
RA Hollister J.D., Ossowski S., Ottilar R.P., Salamov A.A., Schneeberger K.,
RA Spannagl M., Wang X., Yang L., Nasrallah M.E., Bergelson J.,
RA Carrington J.C., Gaut B.S., Schmutz J., Mayer K.F.X., Van de Peer Y.,
RA Grigoriev I.V., Nordborg M., Weigel D., Guo Y.-L.;
RT "The Arabidopsis lyrata genome sequence and the basis of rapid genome size
RT change.";
RL Nat. Genet. 43:476-481(2011).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
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DR EMBL; GL348713; EFH70820.1; -; Genomic_DNA.
DR RefSeq; XP_002894561.1; XM_002894515.1.
DR AlphaFoldDB; D7KNW0; -.
DR STRING; 81972.D7KNW0; -.
DR EnsemblPlants; scaffold_105433.1; scaffold_105433.1; scaffold_105433.1.
DR Gramene; scaffold_105433.1; scaffold_105433.1; scaffold_105433.1.
DR eggNOG; ENOG502QUW9; Eukaryota.
DR HOGENOM; CLU_000288_114_2_1; -.
DR Proteomes; UP000008694; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-EC.
DR Gene3D; 2.60.120.430; Galactose-binding lectin; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR021720; Malectin_dom.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR PANTHER; PTHR48006:SF94; LEUCINE-RICH REPEAT TRANSMEMBRANE PROTEIN KINASE; 1.
DR PANTHER; PTHR48006; LEUCINE-RICH REPEAT-CONTAINING PROTEIN DDB_G0281931-RELATED; 1.
DR Pfam; PF00560; LRR_1; 3.
DR Pfam; PF11721; Malectin; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW Reference proteome {ECO:0000313|Proteomes:UP000008694};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..900
FT /note="non-specific serine/threonine protein kinase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003101466"
FT TRANSMEM 617..639
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 673..900
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 875..900
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 702
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 900 AA; 98325 MW; 587B24B78FC75667 CRC64;
MLRLRRSLFL LLTVWFLYSS GSVHVVVRAQ NQNGATTHPD EVIVETTARA LNSIFATWKI
QAPKEWNISG ELCSGAAIND VTIDDKDHNP LIKCGCTFVN STICRITALK VYARDVVGPI
PQELWTLIFL TNLNLAQNFL TGSLSPAIGN LTLMQWMTFG INALSGPVPK EIGRLTDLRS
LSIGSNNFSG SIPAEIGNCT KLQQIYIGSS GLNGEIPLSL ANLVELTVAW IMDLEVTGRI
PDFIGNWTKL TTLRIMGTGL SGPIPSSFSN LTSLSQLVLR NNNLTGTIPS NIGDYSSLLQ
VDLSFNKLHG PIPASLFNLS QLTHLFLGNN TLNGSLPTQK RQSLINIDVS YNDLSGSLPS
WISLPNLKLN LVANNFTLEG LDNSVLSGLN CLQKNFACNR GKGIYYNFSI NCGGPEIRSA
SGALYEKEDM DLGPASFVVS AAQRWAASSV GNFAGSSRNK YRETSQSQFI NTLDSELFQS
ARLSASSLRY YGLGLENGGY TVTLQFAEIQ IQGSNSWKGI GRRRFDIYVQ GRLVEKDFDI
RRTAGGSSVR AVQREYKTNV SENHLEVHLF WAGKGTCCIP IQGAYGPLIS AVSATPDFTP
TVANRPPSKE KNMTGTIVGV IVAVGLLSIL AGVVIFIILK SRKPYTDDEE ILSMDIKPYT
FTYSILKSAT QDFDPSNKLG EGAFGVVYKG TLNDGREIAV KKLSSVGSRH GKGQFVAEIV
AISSVLHRNL VKLYGCCFEG DQRLLVYEYL SNGSLDDALF VSGRKNSDEN LEEGKKYLLE
WAWNLHEKSR DVELIDDELG EYNMEEVKCM IGVALLCTQS SHALRPPMSR VVAMLSGDAE
VNDATSKPGH LIDSIYDDTT SSSYSGFQTK DTSFSTSFVT PGPRDSDSKP MLGFKIKEGR
//
