ID D7KT96_ARALL Unreviewed; 359 AA.
AC D7KT96;
DT 10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT 10-AUG-2010, sequence version 1.
DT 24-JAN-2024, entry version 60.
DE RecName: Full=Methyltransferase {ECO:0000256|RuleBase:RU362025};
DE EC=2.1.1.- {ECO:0000256|RuleBase:RU362025};
GN Name=SMT3 {ECO:0000313|EMBL:EFH65316.1};
GN ORFNames=ARALYDRAFT_895486 {ECO:0000313|EMBL:EFH65316.1};
OS Arabidopsis lyrata subsp. lyrata (Lyre-leaved rock-cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=81972 {ECO:0000313|Proteomes:UP000008694};
RN [1] {ECO:0000313|Proteomes:UP000008694}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. MN47 {ECO:0000313|Proteomes:UP000008694};
RX PubMed=21478890; DOI=10.1038/ng.807;
RA Hu T.T., Pattyn P., Bakker E.G., Cao J., Cheng J.-F., Clark R.M.,
RA Fahlgren N., Fawcett J.A., Grimwood J., Gundlach H., Haberer G.,
RA Hollister J.D., Ossowski S., Ottilar R.P., Salamov A.A., Schneeberger K.,
RA Spannagl M., Wang X., Yang L., Nasrallah M.E., Bergelson J.,
RA Carrington J.C., Gaut B.S., Schmutz J., Mayer K.F.X., Van de Peer Y.,
RA Grigoriev I.V., Nordborg M., Weigel D., Guo Y.-L.;
RT "The Arabidopsis lyrata genome sequence and the basis of rapid genome size
RT change.";
RL Nat. Genet. 43:476-481(2011).
CC -!- PATHWAY: Steroid biosynthesis; sterol biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004938}.
CC -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC superfamily. Erg6/SMT family. {ECO:0000256|PROSITE-ProRule:PRU01022,
CC ECO:0000256|RuleBase:RU362025}.
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DR EMBL; GL348714; EFH65316.1; -; Genomic_DNA.
DR RefSeq; XP_002889057.1; XM_002889011.1.
DR AlphaFoldDB; D7KT96; -.
DR STRING; 81972.D7KT96; -.
DR EnsemblPlants; scaffold_202560.1; scaffold_202560.1; scaffold_202560.1.
DR GeneID; 9325120; -.
DR Gramene; scaffold_202560.1; scaffold_202560.1; scaffold_202560.1.
DR KEGG; aly:9325120; -.
DR eggNOG; KOG1269; Eukaryota.
DR HOGENOM; CLU_039068_5_2_1; -.
DR OrthoDB; 716003at2759; -.
DR UniPathway; UPA00766; -.
DR Proteomes; UP000008694; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0008757; F:S-adenosylmethionine-dependent methyltransferase activity; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0016126; P:sterol biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR013216; Methyltransf_11.
DR InterPro; IPR030384; MeTrfase_SMT.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR013705; Sterol_MeTrfase_C.
DR PANTHER; PTHR44742; -; 1.
DR PANTHER; PTHR44742:SF5; 24-METHYLENESTEROL C-METHYLTRANSFERASE 3; 1.
DR Pfam; PF08241; Methyltransf_11; 1.
DR Pfam; PF08498; Sterol_MT_C; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS51685; SAM_MT_ERG6_SMT; 1.
PE 3: Inferred from homology;
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603, ECO:0000256|PROSITE-
KW ProRule:PRU01022}; Reference proteome {ECO:0000313|Proteomes:UP000008694};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691,
KW ECO:0000256|PROSITE-ProRule:PRU01022};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PROSITE-
KW ProRule:PRU01022}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 6..27
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 77..354
FT /note="SAM-dependent methyltransferase Erg6/SMT-type"
FT /evidence="ECO:0000259|PROSITE:PS51685"
SQ SEQUENCE 359 AA; 40269 MW; 8AA78F8995608D03 CRC64;
MDSVALYCTA GLIAGALYWF ICVLGPAERK GKRALDLSGG SINAENVKDN YNQYWSFFRR
PKEIETAEKV PDFVDTFYNL VTDIYEWGWG QSFHFSPHIP GKSHKDATRI HEEMAVDLIN
VKPGQKILDA GCGVGGPMRA IAAHSKAQVT GITINEYQVQ RAKLHNKKAG LDSLCNVVCG
NFLKMPFDEN TFDGAYSIEA TCHAPKLEEV YSEIFRVMKP GSLFVSYEWV TTEKYRDEDE
EHKDVIQGIE RGDALPGLRS YIDIAATAKK VGFEVVKEKD LAKPPSKPWW NRLKMGRLAY
WRNHVVVVIL SAIGVAPKGT VDVHKMLFKT ADYLTRGGET GIFSPMHMIL CRKPEKASE
//
