ID   D7LBQ3_ARALL            Unreviewed;       350 AA.
AC   D7LBQ3;
DT   10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT   10-AUG-2010, sequence version 1.
DT   24-JAN-2024, entry version 58.
DE   RecName: Full=methenyltetrahydrofolate cyclohydrolase {ECO:0000256|ARBA:ARBA00012776};
DE            EC=3.5.4.9 {ECO:0000256|ARBA:ARBA00012776};
GN   ORFNames=ARALYDRAFT_482876 {ECO:0000313|EMBL:EFH56017.1};
OS   Arabidopsis lyrata subsp. lyrata (Lyre-leaved rock-cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=81972 {ECO:0000313|Proteomes:UP000008694};
RN   [1] {ECO:0000313|Proteomes:UP000008694}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. MN47 {ECO:0000313|Proteomes:UP000008694};
RX   PubMed=21478890; DOI=10.1038/ng.807;
RA   Hu T.T., Pattyn P., Bakker E.G., Cao J., Cheng J.-F., Clark R.M.,
RA   Fahlgren N., Fawcett J.A., Grimwood J., Gundlach H., Haberer G.,
RA   Hollister J.D., Ossowski S., Ottilar R.P., Salamov A.A., Schneeberger K.,
RA   Spannagl M., Wang X., Yang L., Nasrallah M.E., Bergelson J.,
RA   Carrington J.C., Gaut B.S., Schmutz J., Mayer K.F.X., Van de Peer Y.,
RA   Grigoriev I.V., Nordborg M., Weigel D., Guo Y.-L.;
RT   "The Arabidopsis lyrata genome sequence and the basis of rapid genome size
RT   change.";
RL   Nat. Genet. 43:476-481(2011).
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DR   EMBL; GL348716; EFH56017.1; -; Genomic_DNA.
DR   RefSeq; XP_002879758.1; XM_002879712.1.
DR   AlphaFoldDB; D7LBQ3; -.
DR   STRING; 81972.D7LBQ3; -.
DR   EnsemblPlants; fgenesh2_kg.4__1936__AT2G38660.3; fgenesh2_kg.4__1936__AT2G38660.3; fgenesh2_kg.4__1936__AT2G38660.3.
DR   Gramene; fgenesh2_kg.4__1936__AT2G38660.3; fgenesh2_kg.4__1936__AT2G38660.3; fgenesh2_kg.4__1936__AT2G38660.3.
DR   eggNOG; KOG0089; Eukaryota.
DR   HOGENOM; CLU_034045_1_2_1; -.
DR   Proteomes; UP000008694; Unassembled WGS sequence.
DR   GO; GO:0004477; F:methenyltetrahydrofolate cyclohydrolase activity; IEA:UniProtKB-EC.
DR   GO; GO:0004488; F:methylenetetrahydrofolate dehydrogenase (NADP+) activity; IEA:InterPro.
DR   GO; GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
DR   CDD; cd01080; NAD_bind_m-THF_DH_Cyclohyd; 1.
DR   Gene3D; 3.40.50.10860; Leucine Dehydrogenase, chain A, domain 1; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   HAMAP; MF_01576; THF_DHG_CYH; 1.
DR   InterPro; IPR046346; Aminoacid_DH-like_N_sf.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR000672; THF_DH/CycHdrlase.
DR   InterPro; IPR020630; THF_DH/CycHdrlase_cat_dom.
DR   InterPro; IPR020867; THF_DH/CycHdrlase_CS.
DR   InterPro; IPR020631; THF_DH/CycHdrlase_NAD-bd_dom.
DR   PANTHER; PTHR48099:SF10; BIFUNCTIONAL PROTEIN FOLD 1, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR48099; C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC-RELATED; 1.
DR   Pfam; PF00763; THF_DHG_CYH; 1.
DR   Pfam; PF02882; THF_DHG_CYH_C; 1.
DR   PRINTS; PR00085; THFDHDRGNASE.
DR   SUPFAM; SSF53223; Aminoacid dehydrogenase-like, N-terminal domain; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   PROSITE; PS00767; THF_DHG_CYH_2; 1.
PE   3: Inferred from homology;
KW   One-carbon metabolism {ECO:0000256|ARBA:ARBA00022563};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008694}.
FT   DOMAIN          64..179
FT                   /note="Tetrahydrofolate dehydrogenase/cyclohydrolase
FT                   catalytic"
FT                   /evidence="ECO:0000259|Pfam:PF00763"
FT   DOMAIN          182..347
FT                   /note="Tetrahydrofolate dehydrogenase/cyclohydrolase
FT                   NAD(P)-binding"
FT                   /evidence="ECO:0000259|Pfam:PF02882"
SQ   SEQUENCE   350 AA;  37779 MW;  A586FCB942B96349 CRC64;
     MIARKALASA HTKAIRLTTR DVHCFSSILV SPPLVSLDLP ENWIPYSDPP PPVSFETEQK
     TVVIDGNVIA EEIRTKISSE VRKMKKAVGK VPGLAVVLVG QQRDSQTYVR NKIKACEETG
     IKSILAELPE DCTEGQILSI LKKFNEDTSI HGILVQLPLP QHLDESKILN MVRLEKDVDG
     FHPLNVGNLA MRGREPLFVS CTPKGCVELL IRAGVEIAGK NAVVIGRSNI VGLPMSLLLQ
     RHDATVSTVH AFTKDPEQIT RKADIVIAAA GIPSLVRGSW LKPGAVVIDV GTSPVEDSSC
     EFGYRLVGDV CYEEALGVAS AITPVPGGVG PMTITMLLCN TLDAAKRIFL
//