ID D7LFK4_ARALL Unreviewed; 1002 AA.
AC D7LFK4;
DT 10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT 10-AUG-2010, sequence version 1.
DT 24-JAN-2024, entry version 63.
DE RecName: Full=26S proteasome non-ATPase regulatory subunit 1 homolog {ECO:0000256|PIRNR:PIRNR015947};
GN ORFNames=ARALYDRAFT_482209 {ECO:0000313|EMBL:EFH55668.1};
OS Arabidopsis lyrata subsp. lyrata (Lyre-leaved rock-cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=81972 {ECO:0000313|Proteomes:UP000008694};
RN [1] {ECO:0000313|Proteomes:UP000008694}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. MN47 {ECO:0000313|Proteomes:UP000008694};
RX PubMed=21478890; DOI=10.1038/ng.807;
RA Hu T.T., Pattyn P., Bakker E.G., Cao J., Cheng J.-F., Clark R.M.,
RA Fahlgren N., Fawcett J.A., Grimwood J., Gundlach H., Haberer G.,
RA Hollister J.D., Ossowski S., Ottilar R.P., Salamov A.A., Schneeberger K.,
RA Spannagl M., Wang X., Yang L., Nasrallah M.E., Bergelson J.,
RA Carrington J.C., Gaut B.S., Schmutz J., Mayer K.F.X., Van de Peer Y.,
RA Grigoriev I.V., Nordborg M., Weigel D., Guo Y.-L.;
RT "The Arabidopsis lyrata genome sequence and the basis of rapid genome size
RT change.";
RL Nat. Genet. 43:476-481(2011).
CC -!- FUNCTION: Acts as a regulatory subunit of the 26S proteasome which is
CC involved in the ATP-dependent degradation of ubiquitinated proteins.
CC {ECO:0000256|PIRNR:PIRNR015947}.
CC -!- SUBUNIT: Component of the 19S regulatory particle (RP/PA700) base
CC subcomplex of the 26S proteasome. The 26S proteasome is composed of a
CC core protease (CP), known as the 20S proteasome, capped at one or both
CC ends by the 19S regulatory particle (RP/PA700).
CC {ECO:0000256|PIRNR:PIRNR015947}.
CC -!- SIMILARITY: Belongs to the proteasome subunit S1 family.
CC {ECO:0000256|ARBA:ARBA00006308, ECO:0000256|PIRNR:PIRNR015947}.
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DR EMBL; GL348716; EFH55668.1; -; Genomic_DNA.
DR RefSeq; XP_002879409.1; XM_002879363.1.
DR AlphaFoldDB; D7LFK4; -.
DR STRING; 81972.D7LFK4; -.
DR EnsemblPlants; fgenesh2_kg.4__1269__AT2G32730.1; fgenesh2_kg.4__1269__AT2G32730.1; fgenesh2_kg.4__1269__AT2G32730.1.
DR GeneID; 9317307; -.
DR Gramene; fgenesh2_kg.4__1269__AT2G32730.1; fgenesh2_kg.4__1269__AT2G32730.1; fgenesh2_kg.4__1269__AT2G32730.1.
DR KEGG; aly:9317307; -.
DR eggNOG; KOG2062; Eukaryota.
DR HOGENOM; CLU_002323_0_0_1; -.
DR OrthoDB; 151732at2759; -.
DR Proteomes; UP000008694; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0008540; C:proteasome regulatory particle, base subcomplex; IEA:UniProtKB-UniRule.
DR GO; GO:0030234; F:enzyme regulator activity; IEA:UniProtKB-UniRule.
DR GO; GO:0042176; P:regulation of protein catabolic process; IEA:UniProtKB-UniRule.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR016642; 26S_Psome_Rpn2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR002015; Proteasome/cyclosome_rpt.
DR InterPro; IPR048570; PSMD1_RPN2_N.
DR InterPro; IPR040623; RPN2_C.
DR PANTHER; PTHR10943; 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10943:SF2; 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 1; 1.
DR Pfam; PF13646; HEAT_2; 1.
DR Pfam; PF01851; PC_rep; 1.
DR Pfam; PF18004; RPN2_C; 1.
DR Pfam; PF21505; RPN2_N; 1.
DR PIRSF; PIRSF015947; 26S_Psome_Rpn2; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Proteasome {ECO:0000256|ARBA:ARBA00022942, ECO:0000256|PIRNR:PIRNR015947};
KW Reference proteome {ECO:0000313|Proteomes:UP000008694};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 780..803
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 8..353
FT /note="26S proteasome non-ATPase regulatory subunit 1/RPN2
FT N-terminal"
FT /evidence="ECO:0000259|Pfam:PF21505"
FT DOMAIN 796..959
FT /note="26S proteasome regulatory subunit RPN2 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF18004"
FT REGION 858..903
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 962..1002
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 962..981
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1002 AA; 108776 MW; 11A3955A510F16ED CRC64;
MATPMVSSAG GLLAMLNEPH PALKLHALSY LNNLVDQFWP EISTSVPIIE SLYEDEEFDL
HQRQLAALLV SKVFYYLGEL NDSLSYALGA GPLFDVSEDS DYVHTLLAKA IDEYASLRSK
AVESNEMVDI DPRLEAIVER MLGKCISDGK YQQAMGIAIE CRRLDKLEEA ITKSDNVQGT
LSYCINVSHS FVNRREYRHE VLSLLVKVYQ KLPSPDYLSI CQCLMFLDEP QGVASILEKL
LRSESKDDAL LALQIAFDLV ENEHQAFLLS VRDRLPAPKT RPVEATQAVE TTTAPNENPL
GDVQMADETP AQTIVHETDP VDATYAERLT KIKGILSGET SIQLTLQFLY SHNKSDLLIL
KTIKQSVEMR NSVCHSATIY ANAIMHAGTT VDTFLRENLD WLSRATNWAK FSATAGLGVI
HRGHLQQGRS LMAPYLPQGG AGGGGSPYSE GGALYALGLI HANHGEGIKQ FLRDSLRSTN
VEVIQHGACL GLGLSALGTA DEEIYDDVKS VLYTDSAVAG EAAGISMGLL LVGTATEKAS
EMLAYAHETQ HEKIIRGLAL GIALTVYGRE EGADTLIEQM TRDQDPIIRY GGMYALALAY
SGTANNKAIR QLLHFAVSDV SDDVRRTAVL ALGFVLYSDP EQTPRIVSLL SESYNPHVRY
GAALAVGISC AGTGLSEAIS LLEPLTSDVV DFVRQGALIA MAMVMVQISE ASDSRVGAFR
RQLEKIILDK HEDTMSKMGA ILASGILDAG GRNVTIRLLS KTKHDKVTAV IGLAVFSQFW
YWYPLIYFIS LAFSPTAFIG LNYDLKVPKF EFMSHAKPSL FEYPKPTTVP TANTAVKLPT
AVLSTSVKAK ARAKKEAEQK AIAEKTSGPE KPVNESGSGK GKASTEKEGD SMQVDSPAAV
EKKAAEPEPA FEILVNPARV VPAQEKYIKL LEDSRYVPVK LAPSGFVLLK DLRQHEPEVL
SLTDAPTSTA SPATGAAAQG TTASAMAVDD EPQPPQAFDY AS
//
