ID D7M0D4_ARALL Unreviewed; 1212 AA.
AC D7M0D4;
DT 10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT 10-AUG-2010, sequence version 1.
DT 24-JAN-2024, entry version 63.
DE RecName: Full=ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase {ECO:0000256|ARBA:ARBA00011982};
DE EC=3.2.2.6 {ECO:0000256|ARBA:ARBA00011982};
GN ORFNames=ARALYDRAFT_327329 {ECO:0000313|EMBL:EFH51000.1};
OS Arabidopsis lyrata subsp. lyrata (Lyre-leaved rock-cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=81972 {ECO:0000313|Proteomes:UP000008694};
RN [1] {ECO:0000313|Proteomes:UP000008694}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. MN47 {ECO:0000313|Proteomes:UP000008694};
RX PubMed=21478890; DOI=10.1038/ng.807;
RA Hu T.T., Pattyn P., Bakker E.G., Cao J., Cheng J.-F., Clark R.M.,
RA Fahlgren N., Fawcett J.A., Grimwood J., Gundlach H., Haberer G.,
RA Hollister J.D., Ossowski S., Ottilar R.P., Salamov A.A., Schneeberger K.,
RA Spannagl M., Wang X., Yang L., Nasrallah M.E., Bergelson J.,
RA Carrington J.C., Gaut B.S., Schmutz J., Mayer K.F.X., Van de Peer Y.,
RA Grigoriev I.V., Nordborg M., Weigel D., Guo Y.-L.;
RT "The Arabidopsis lyrata genome sequence and the basis of rapid genome size
RT change.";
RL Nat. Genet. 43:476-481(2011).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + NAD(+) = ADP-D-ribose + H(+) + nicotinamide;
CC Xref=Rhea:RHEA:16301, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:17154, ChEBI:CHEBI:57540, ChEBI:CHEBI:57967; EC=3.2.2.6;
CC Evidence={ECO:0000256|ARBA:ARBA00000404};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16302;
CC Evidence={ECO:0000256|ARBA:ARBA00000404};
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DR EMBL; GL348718; EFH51000.1; -; Genomic_DNA.
DR RefSeq; XP_002874741.1; XM_002874695.1.
DR AlphaFoldDB; D7M0D4; -.
DR STRING; 81972.D7M0D4; -.
DR EnsemblPlants; fgenesh1_pm.C_scaffold_6002549; fgenesh1_pm.C_scaffold_6002549; fgenesh1_pm.C_scaffold_6002549.
DR GeneID; 9310808; -.
DR Gramene; fgenesh1_pm.C_scaffold_6002549; fgenesh1_pm.C_scaffold_6002549; fgenesh1_pm.C_scaffold_6002549.
DR KEGG; aly:9310808; -.
DR eggNOG; ENOG502SI7S; Eukaryota.
DR HOGENOM; CLU_001561_0_3_1; -.
DR OrthoDB; 664773at2759; -.
DR Proteomes; UP000008694; Unassembled WGS sequence.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0042742; P:defense response to bacterium; IEA:EnsemblPlants.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR045344; C-JID.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR011713; Leu-rich_rpt_3.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11017:SF479; DISEASE RESISTANCE-LIKE PROTEIN DSC1; 1.
DR PANTHER; PTHR11017; LEUCINE-RICH REPEAT-CONTAINING PROTEIN; 1.
DR Pfam; PF20160; C-JID; 1.
DR Pfam; PF07725; LRR_3; 1.
DR Pfam; PF13855; LRR_8; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF01582; TIR; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52075; Outer arm dynein light chain 1; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS51450; LRR; 1.
DR PROSITE; PS50104; TIR; 1.
PE 4: Predicted;
KW Plant defense {ECO:0000256|ARBA:ARBA00022821};
KW Reference proteome {ECO:0000313|Proteomes:UP000008694}.
FT DOMAIN 9..165
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
SQ SEQUENCE 1212 AA; 137621 MW; 02F37E083FDBDF9C CRC64;
MESSTPPSAE FDVFLSFRGF DTRNNFTGHL QKALRLRGID SFIDDRLHRG DNLTALFDRI
EKSKIAIIIF STNYANSAWC LRELVKILEC RNRNQQLVVP IFYKVEKSDV KIQELTFPGV
SPEEISSWKA ALVSASNILG YVVKEISTSE ANLVDEIAVD TFKKLNDLAP SGNEGLVGIE
SRLKNLEKLL SWEDLDSVHI IGIVGMVGIG KTTLADCLYG RMRGRFDGSC FLTNIRENSG
RSGLEYLLQK LFSTVLNDRD LEIGAPGNAH ERFERRLKSK RLLIVLDDVN DEKQIRYLMG
HCKWYQGGSR IIITTRDCKL IETIKGRKYV LPKLNDREAL KLFSLNAFND SCPSKEFEGL
TNMVLDYAKG HPLALKVLGS DLCERDNLYW EAKLDRLKCR SHGDIYEVLE TSYEELTIEQ
KNVFLDIACF FRSENVDYVT SLLNSHGVDV SSVIKDLVDK CLITLSDNRI EMHDMLQTMG
KEISLKAETI GIRDFTWLSR HGNQCQWHIR LWDSEDICDI LTKGQGTDKI RGIFLDTSKL
RAMRLSAKAL KGMYNLKYLK IYDSHCSRGC EVEFKLHLRK GLDYLPNELT YLHWHGYPLQ
SIPLDFDPKN LVDLKLPHSQ LAEIWDDEKD AGMLKWVDLS HSLNLHQCLG LANAQNLERL
NLEGCTSLKK LPTTINGLEK LVYLNLRDCT SLRSLPKGLK TQSLQTLILS GCSRLKKFPL
ISENVEVLLL DGTAIKSLPE SIETLRRLAL LNLKNCKKLK HLSSDLYKLK CLQELILSGC
SRLEVFPEIK EDMESLEILL MDDTAITEMP KMMHLSNIQT FSLCGTSSQV SVSMFFMPPT
LGCSRLTDLY LSRCSLYKLP DNIGGLSSLQ SLCLSGNNIE NLPESFNQLH NLKWFDLKFC
KMLKSLPVLP QNLQYLDAHE CESLETLENP LTPLTVGERI HSMFIFSNCY KLNQDAQSLV
GHARIKSQLM ANASVKRYYR GFIPEPLVGI CYAATDIPSW FCHQRLGRSL EIPLPPHWCD
TDFVGLALSV VVSFMDYEDS AKRFSVKCCG KFENQDGSFT RFDFTLAGWN EPCGSLSHEP
RKLASDHVFM GYNSCFHVKN LHGESKNCCY TKASFEFYVT DDETRKKIET CEVIKCGMSL
VYVPEDDDCM LLKKTNIVQL SLKSGPSCTE PTCSYGLDDV MDDVRPKRGL CQFVGGGEPD
CKRTKEEKIT VR
//