ID   D7MUS6_ARALL            Unreviewed;      1064 AA.
AC   D7MUS6;
DT   10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT   10-AUG-2010, sequence version 1.
DT   27-MAR-2024, entry version 63.
DE   RecName: Full=TIR domain-containing protein {ECO:0000259|Pfam:PF01582};
GN   ORFNames=ARALYDRAFT_916966 {ECO:0000313|EMBL:EFH39760.1};
OS   Arabidopsis lyrata subsp. lyrata (Lyre-leaved rock-cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=81972 {ECO:0000313|Proteomes:UP000008694};
RN   [1] {ECO:0000313|Proteomes:UP000008694}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. MN47 {ECO:0000313|Proteomes:UP000008694};
RX   PubMed=21478890; DOI=10.1038/ng.807;
RA   Hu T.T., Pattyn P., Bakker E.G., Cao J., Cheng J.-F., Clark R.M.,
RA   Fahlgren N., Fawcett J.A., Grimwood J., Gundlach H., Haberer G.,
RA   Hollister J.D., Ossowski S., Ottilar R.P., Salamov A.A., Schneeberger K.,
RA   Spannagl M., Wang X., Yang L., Nasrallah M.E., Bergelson J.,
RA   Carrington J.C., Gaut B.S., Schmutz J., Mayer K.F.X., Van de Peer Y.,
RA   Grigoriev I.V., Nordborg M., Weigel D., Guo Y.-L.;
RT   "The Arabidopsis lyrata genome sequence and the basis of rapid genome size
RT   change.";
RL   Nat. Genet. 43:476-481(2011).
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DR   EMBL; GL348720; EFH39760.1; -; Genomic_DNA.
DR   RefSeq; XP_002863501.1; XM_002863455.1.
DR   AlphaFoldDB; D7MUS6; -.
DR   EnsemblPlants; scaffold_800366.1; scaffold_800366.1; scaffold_800366.1.
DR   Gramene; scaffold_800366.1; scaffold_800366.1; scaffold_800366.1.
DR   eggNOG; ENOG502SI7S; Eukaryota.
DR   HOGENOM; CLU_001561_0_0_1; -.
DR   Proteomes; UP000008694; Unassembled WGS sequence.
DR   GO; GO:0006952; P:defense response; IEA:InterPro.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 3.
DR   Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR   InterPro; IPR044974; Disease_R_plants.
DR   InterPro; IPR025875; Leu-rich_rpt_4.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR000157; TIR_dom.
DR   InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR11017:SF549; DISEASE RESISTANCE PROTEIN RPP2A; 1.
DR   PANTHER; PTHR11017; LEUCINE-RICH REPEAT-CONTAINING PROTEIN; 1.
DR   Pfam; PF12799; LRR_4; 1.
DR   Pfam; PF01582; TIR; 1.
DR   PRINTS; PR00364; DISEASERSIST.
DR   SUPFAM; SSF52058; L domain-like; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000008694}.
FT   DOMAIN          71..153
FT                   /note="TIR"
FT                   /evidence="ECO:0000259|Pfam:PF01582"
SQ   SEQUENCE   1064 AA;  120764 MW;  EE8CCA595EF5F411 CRC64;
     MSESMEGSDP QLQVSERRKI WTAELHDRFV DVVNALGGSE RGSEPSLLLR YDLVTDTKTR
     IRDLNTLNGV FILLFSKTYA SAESMDKLVT LMEYQKENGV LIIPIFFKVT PSEVQDPKGF
     TKETFSQLDN SVQAGRVQKW REVIDELAHN DECKWIAGNR QVLVQCKVNG LYEMQKLSEY
     ESSETFSLSL PGRYDSMLNS ELVRYASGIP LVLGVLGSFA TNQCKFSEKE QLQMLRQNPP
     TEILEAFRRS FDGLNDNEKN MFLDLACFFR GENRNHVIQI LDGCGYFTDL GIYGLIDESL
     IDPLENKIEM SNVFQDMGRF VVCEESKEPG KRSRLWDANE IANVLTSNSG TEAVEGIFLD
     MSDLTCELSP TIFDRTYRLR LLKLHCAISE NRGTICLPRG LYSLPDELRL LHWESYPLRS
     LPRENLEKLK KIILSHSRQL IKIPRLSKAL NLEHIDLEGC TSLVKVSSSI HHLDKLVFLN
     LKDCSRLRTL PVMIHLESLE VLNLSGCSDL KEIQDFSPNL KELYLAGTAI RELPSSIEKL
     TRLVTLDLDN CNQLQKLPQG MSNLKAMVTL KLSGCSNLKS LPNLDAIYLR GTQHLNTEIT
     MEVPKSLVHH SSIHQSRLDH CETLDKLIPD LCLKNAAIQK SLAASVYRQI AGIRQENWQW
     STIKLQPLSI FHFLASRLYA LVSLCLSNAC LVDLPKEICG LPSVNILDLG GNGFSKIPES
     IKLLPKLHSL RLRHCKNLKS LPELPQSLVL LNVHGCVSMK SVPWSFERLQ CTFSNCFNLS
     PEVIRRFLAK ALGIVKNMNR EKHQKLITVT AFSICAPASV GLKSSTDVLA SEGLKSSMQN
     GSFVVIHLTS SLRKTFLGFA MSVVVSFRDN YYNAAGFSIR CTCIRKMKNG LSHRLERVFQ
     FWAPKEASKI KKDHIFVFYD TIIPSYAREG NNVYNIFDEL VGFEFYPVNN QNEVLADSCE
     VKNCGVYVVT DASVDTSLVK KRFSPTNRER IGKRPLASAM DPRGFSSYRE PLPRFKRGRY
     RRSVETAILK IRKRKREEGF YVSNQRCESE TFLISNLTLF LLKK
//