ID D7NTR3_HUMAN Unreviewed; 303 AA.
AC D7NTR3;
DT 10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT 10-AUG-2010, sequence version 1.
DT 24-JAN-2024, entry version 58.
DE RecName: Full=Bone morphogenetic protein 3 {ECO:0000256|ARBA:ARBA00013361};
DE Flags: Fragment;
GN Name=BMP3 {ECO:0000313|EMBL:ACT09865.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|EMBL:ACT09865.1};
RN [1] {ECO:0000313|EMBL:ACT09865.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=1415 {ECO:0000313|EMBL:ACT09865.1}, 1416
RC {ECO:0000313|EMBL:ACT09866.1}, 456 {ECO:0000313|EMBL:ACT09894.1}, 912
RC {ECO:0000313|EMBL:ACT09940.1}, and 982 {ECO:0000313|EMBL:ACT09949.1};
RA Wu D.-D., Jin W., Zhang Y.-P.;
RL Submitted (MAY-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ACT09865.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=1415 {ECO:0000313|EMBL:ACT09865.1}, 1416
RC {ECO:0000313|EMBL:ACT09866.1}, 456 {ECO:0000313|EMBL:ACT09894.1}, 912
RC {ECO:0000313|EMBL:ACT09940.1}, and 982 {ECO:0000313|EMBL:ACT09949.1};
RX PubMed=20532035; DOI=10.1371/journal.pone.0010959;
RA Wu D.D., Jin W., Hao X.D., Tang N.L., Zhang Y.P.;
RT "Evidence for positive selection on the Osteogenin (BMP3) gene in human
RT populations.";
RL PLoS ONE 5:E10959-E10959(2010).
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
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DR EMBL; GQ291788; ACT09865.1; -; Genomic_DNA.
DR EMBL; GQ291789; ACT09866.1; -; Genomic_DNA.
DR EMBL; GQ291817; ACT09894.1; -; Genomic_DNA.
DR EMBL; GQ291863; ACT09940.1; -; Genomic_DNA.
DR EMBL; GQ291872; ACT09949.1; -; Genomic_DNA.
DR PeptideAtlas; D7NTR3; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR11848:SF144; BONE MORPHOGENETIC PROTEIN 3; 1.
DR PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|RuleBase:RU000354}; Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 254..303
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
FT REGION 214..247
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ACT09865.1"
FT NON_TER 303
FT /evidence="ECO:0000313|EMBL:ACT09865.1"
SQ SEQUENCE 303 AA; 34980 MW; 5BB536FB5E2EF703 CRC64;
TLERKGLYIF NLTSLTKSEN ILSATLYFCI GELGNISLSC PVSGGCSHHA QRKHIQIDLS
AWTLKFSRNQ SQLLGHLSVD MAKSHRDIMS WLSKDITQFL RKAKENEEFL IGFNIXSKGR
QLPKRRLPFP EPYILVYAND AAISEPESVV SSLQGHRNFP TGTVPKWDSH IRAALSIERR
KKRSTGVLLP LQNNELPGAE YQYKKDEVWE ERKPYKTLQA QAPEKSKNKK KQRKGPHRKS
QTLQFDEQTL KKARRKQWIE PRNCARRYLK VDFADIGWSE WIISPKSFDA YYCSGACQFP
MPK
//
