ID   D7PPM4_ACRPL            Unreviewed;       451 AA.
AC   D7PPM4;
DT   10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT   10-AUG-2010, sequence version 1.
DT   27-MAR-2024, entry version 39.
DE   SubName: Full=Caspase 8 {ECO:0000313|EMBL:ADG23096.1};
GN   Name=casp8 {ECO:0000313|EMBL:ADG23096.1};
OS   Acropora palmata (Elkhorn coral).
OC   Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Scleractinia;
OC   Astrocoeniina; Acroporidae; Acropora.
OX   NCBI_TaxID=6131 {ECO:0000313|EMBL:ADG23096.1};
RN   [1] {ECO:0000313|EMBL:ADG23096.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Sakamaki K., Kimura H.;
RT   "Isolation of caspase 8 from the stony coral, Acropora palmata.";
RL   Submitted (FEB-2010) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the peptidase C14A family.
CC       {ECO:0000256|ARBA:ARBA00010134, ECO:0000256|RuleBase:RU003971}.
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DR   EMBL; GU808361; ADG23096.1; -; mRNA.
DR   AlphaFoldDB; D7PPM4; -.
DR   GO; GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR   CDD; cd00045; DED; 2.
DR   Gene3D; 3.40.50.1460; -; 2.
DR   Gene3D; 1.10.533.10; Death Domain, Fas; 2.
DR   InterPro; IPR029030; Caspase-like_dom_sf.
DR   InterPro; IPR011029; DEATH-like_dom_sf.
DR   InterPro; IPR001875; DED_dom.
DR   InterPro; IPR011600; Pept_C14_caspase.
DR   InterPro; IPR002138; Pept_C14_p10.
DR   InterPro; IPR001309; Pept_C14_p20.
DR   InterPro; IPR015917; Pept_C14A.
DR   PANTHER; PTHR48169:SF3; CASP8 AND FADD-LIKE APOPTOSIS REGULATOR A-RELATED; 1.
DR   PANTHER; PTHR48169; DED DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF01335; DED; 2.
DR   Pfam; PF00656; Peptidase_C14; 1.
DR   SMART; SM00115; CASc; 1.
DR   SMART; SM00031; DED; 2.
DR   SUPFAM; SSF52129; Caspase-like; 1.
DR   SUPFAM; SSF47986; DEATH domain; 2.
DR   PROSITE; PS50207; CASPASE_P10; 1.
DR   PROSITE; PS50208; CASPASE_P20; 1.
DR   PROSITE; PS50168; DED; 2.
PE   2: Evidence at transcript level;
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          7..85
FT                   /note="DED"
FT                   /evidence="ECO:0000259|PROSITE:PS50168"
FT   DOMAIN          107..183
FT                   /note="DED"
FT                   /evidence="ECO:0000259|PROSITE:PS50168"
FT   DOMAIN          293..334
FT                   /note="Caspase family p20"
FT                   /evidence="ECO:0000259|PROSITE:PS50208"
FT   DOMAIN          366..448
FT                   /note="Caspase family p10"
FT                   /evidence="ECO:0000259|PROSITE:PS50207"
SQ   SEQUENCE   451 AA;  50798 MW;  12E663E1B0E18C91 CRC64;
     MTMAEGELNS ILFILSNGMG AHDLQNLKHL CHGKIPLGDL EKAQSARDVF RIMRQKLLIR
     PGKLDLLESM LKQIGRADLA KKLQSGGGAD TTMESEGALR RNSLEANYRG FLMTLSDELT
     KENVESLKFI ADLPYGIEER IQNGRDFFKY LQHAGNVGPN LLSHLEDLFG KIHRRDLALK
     VREFQDQQMG VNTINTNKIG VAPVGNMIPR PCPAVSPVTE KQPTMHQMSD VKSPTMVLMS
     PADFSKPSQP SEPSEPRYPV QAMANVTELV DPLQRIGIDQ EDAMPSYPMN QRPRGIALII
     GNEHFGGSTL LRDWQGNEKD IEHLQELWSF LNFQACRGEA FDDGAVMQAD ATEVSPEDAL
     RRNAEPNESH FLLGYATPPG YVSWRSQIHG SWYVSKLCEV FRKYCQQFDV TSVMVKVNDE
     VSEAFTQRGY KQCPAPVVTL RKRIYFNNNW D
//