ID D7R6D4_BIOGL Unreviewed; 1445 AA.
AC D7R6D4;
DT 10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT 10-AUG-2010, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE SubName: Full=Thioester-containing protein 1.2 {ECO:0000313|EMBL:ADE45339.1};
GN Name=TEP1 {ECO:0000313|EMBL:ADE45339.1};
OS Biomphalaria glabrata (Bloodfluke planorb) (Freshwater snail).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Heterobranchia; Euthyneura; Panpulmonata; Hygrophila; Lymnaeoidea;
OC Planorbidae; Biomphalaria.
OX NCBI_TaxID=6526 {ECO:0000313|EMBL:ADE45339.1};
RN [1] {ECO:0000313|EMBL:ADE45339.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Brazil {ECO:0000313|EMBL:ADE45339.1};
RX PubMed=20838648;
RA Mone Y., Gourbal B., Duval D., Du Pasquier L., Kieffer-Jaquinod S.,
RA Mitta G.;
RT "A large repertoire of parasite epitopes matched by a large repertoire of
RT host immune receptors in an invertebrate host/parasite model.";
RL PLoS Negl. Trop. Dis. 4:E813-E813(2010).
CC -!- SIMILARITY: Belongs to the protease inhibitor I39 (alpha-2-
CC macroglobulin) family. {ECO:0000256|ARBA:ARBA00010952}.
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DR EMBL; HM038103; ADE45339.1; -; mRNA.
DR VEuPathDB; VectorBase:BGLB021854; -.
DR GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR Gene3D; 1.50.10.20; -; 1.
DR Gene3D; 2.20.130.20; -; 1.
DR Gene3D; 2.60.120.1540; -; 1.
DR Gene3D; 2.60.40.1930; -; 2.
DR Gene3D; 2.60.40.1940; -; 1.
DR Gene3D; 6.20.50.160; -; 1.
DR Gene3D; 2.60.40.690; Alpha-macroglobulin, receptor-binding domain; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR InterPro; IPR009048; A-macroglobulin_rcpt-bd.
DR InterPro; IPR036595; A-macroglobulin_rcpt-bd_sf.
DR InterPro; IPR011625; A2M_N_BRD.
DR InterPro; IPR047565; Alpha-macroglob_thiol-ester_cl.
DR InterPro; IPR011626; Alpha-macroglobulin_TED.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR001599; Macroglobln_a2.
DR InterPro; IPR019742; MacrogloblnA2_CS.
DR InterPro; IPR002890; MG2.
DR InterPro; IPR041555; MG3.
DR InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR PANTHER; PTHR11412:SF179; LD23292P; 1.
DR PANTHER; PTHR11412; MACROGLOBULIN / COMPLEMENT; 1.
DR Pfam; PF00207; A2M; 1.
DR Pfam; PF07703; A2M_BRD; 1.
DR Pfam; PF07677; A2M_recep; 1.
DR Pfam; PF01835; MG2; 1.
DR Pfam; PF17791; MG3; 1.
DR Pfam; PF07678; TED_complement; 1.
DR SMART; SM01360; A2M; 1.
DR SMART; SM01359; A2M_N_2; 1.
DR SMART; SM01361; A2M_recep; 1.
DR SMART; SM01419; Thiol-ester_cl; 1.
DR SUPFAM; SSF49410; Alpha-macroglobulin receptor domain; 1.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 1.
DR PROSITE; PS00477; ALPHA_2_MACROGLOBULIN; 1.
PE 2: Evidence at transcript level;
KW Protease inhibitor {ECO:0000256|ARBA:ARBA00022690};
KW Serine protease inhibitor {ECO:0000256|ARBA:ARBA00022900};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..1445
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003105489"
FT DOMAIN 463..599
FT /note="Alpha-2-macroglobulin bait region"
FT /evidence="ECO:0000259|SMART:SM01359"
FT DOMAIN 718..808
FT /note="Alpha-2-macroglobulin"
FT /evidence="ECO:0000259|SMART:SM01360"
FT DOMAIN 1342..1426
FT /note="Alpha-macroglobulin receptor-binding"
FT /evidence="ECO:0000259|SMART:SM01361"
SQ SEQUENCE 1445 AA; 160273 MW; EC4F0BABEB4C6262 CRC64;
MRMKLNLILF VFYLVFQECQ GGKYFISAPR NVVPGTAYDI SVDILKQDID NVTVEAILQD
YSFSIPEGPR SLLTANGTFS PGVRGTLSMP IDFNLHCSYC RILLKGYNPL QFEQDIFIQI
SSDILSILIQ TDKAIYKPKE RVNFRILAAY YNLQLYTGTF HYEILDPYDN KINVLSGVSG
TFGVVEGFFD LSDQPSFGTW KINVRTETVS GAESQFFEVA EYDLPRFQVD VGLPPFALLS
DTTLSGSVEA KYTFGQPVYG LVLLQIGENV DTIDKCNVNR KVTEISFEIK GKGNFSVPLE
DIRRSVHLNE KKKIKITAFV TEASTGIKLN GSSVITYYGN RYQIKFLEMT PAVFKPGLQY
TAYVQVTTPD GLPPTDSNLS LSVYTSVTYQ MTVPDQELYS PSSFSGSYPL PGQNMSLPAN
GILSIDIDIP LNATSIDIKV SLNKETTAEK RISKSYSMSN NYLQLSLLSK LVKAESDVLI
KITSTEAIDS LAYEIRSRSD HVKSGVLELS GQREFNATFK VEPSWAPIAQ LLMYYIRRDS
NEVVTDSLAF NVEGMFKNKV NVAFKENETD INKNVSLELS ADSDSQIYVL AVDQSVLLLK
TGNDLTPNKV KDSFISKFHK GAIPTDSNFA LSYSGSSINE VFSNMGLVIA TDLNIFAPFR
PIALGRFPSS GFDRQGMMGA PMAMSFRDDN AMESASFEMD VATSTKPVER VRSFFPESWL
WTSVKSINGH ATLTTTVPDT ITSWIVSAFA TNSDTGLGVA PTTSKLRVFR PFFVSLTYPR
SVTRNEQFIV QATVFNYLPV DLMVTVSLKE NPFLTPITPG PGNQASNIQV RANEQGIVYF
SLSALTVGSL DIEVSARSNM AADAIVRQIL IKHEGAPVVY NNPILINLSN NQSTFEKNIA
FTLPDSLVPE SQRIRVKVTG DLIGSTVQSL TSLLTLPTGC GEQSLVKFTP NIHIGRYLKA
TNQLSEELNK KIIDLLNDGY QRQLTYKRYD NGFSAFGNYD ISSSTWLTAL VVTSFAEAQE
FIFVDKEIIL KASMLLIDRQ NIDGSFNEFG KVLDRNTQGT TAGPALTAFV LVALLKAKEL
ADVQDCKNNN KCRYYLLGNA TLNATRNLER LMLADSIDDQ FSLAVASYAF AEAKSQLAQS
TFEKLLTFVK QEGGLEYWSA NSTVNNEELN RFINWRPPRL QARPIDILIT SYAILTYSSL
GRLDEALPSV RWLTLQKNAQ GGFVSTQDTV VGLQALSSYG SKSFRPDTNI TIYVSDMNTH
LTMNVNSENA LSLQIQEIQS NSQDFSITAS GSGLALLDIE YSFNVLKELS KPVFDVNTVL
LDDKLDSFNI MVCTKFLMKH DTGMVVQELS IPSGFVPDLS TLGQVAGVKR SERKGSIVAI
YFDKISGSSL CYSIVMTREA KVAKSQKSYV RTYDYYEPAN QATVFYQPRT LRDSTVCDVC
LNCCP
//
