ID D7RFJ5_AMYOR Unreviewed; 422 AA.
AC D7RFJ5;
DT 10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT 10-AUG-2010, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=Putative ketosynthase alpha subunit {ECO:0000313|EMBL:ADI71443.1};
GN Name=bexA {ECO:0000313|EMBL:ADI71443.1};
OS Amycolatopsis orientalis subsp. vinearia.
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Amycolatopsis.
OX NCBI_TaxID=797057 {ECO:0000313|EMBL:ADI71443.1};
RN [1] {ECO:0000313|EMBL:ADI71443.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=BA-07585 {ECO:0000313|EMBL:ADI71443.1};
RX PubMed=20443562; DOI=10.1021/ja1014037;
RA Sasaki E., Ogasawara Y., Liu H.W.;
RT "A biosynthetic pathway for BE-7585A, a 2-thiosugar-containing angucycline-
RT type natural product.";
RL J. Am. Chem. Soc. 132:7405-7417(2010).
CC -!- PATHWAY: Antibiotic biosynthesis. {ECO:0000256|ARBA:ARBA00004792}.
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP
CC synthases family. {ECO:0000256|ARBA:ARBA00008467,
CC ECO:0000256|RuleBase:RU003694}.
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DR EMBL; HM055942; ADI71443.1; -; Genomic_DNA.
DR AlphaFoldDB; D7RFJ5; -.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR CDD; cd00834; KAS_I_II; 1.
DR Gene3D; 3.40.47.10; -; 2.
DR InterPro; IPR000794; Beta-ketoacyl_synthase.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR11712:SF336; 3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11712; POLYKETIDE SYNTHASE-RELATED; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
PE 3: Inferred from homology;
KW Antibiotic biosynthesis {ECO:0000256|ARBA:ARBA00023194};
KW Transferase {ECO:0000256|RuleBase:RU003694}.
FT DOMAIN 3..417
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
SQ SEQUENCE 422 AA; 44201 MW; E353452DD5D5C0B3 CRC64;
MTARRVVVTG VGVTAPGGVG AKDFWSLLSE GRTATRRISF FDPSPFRSQV AAEIDFDAEL
LGLGPQEIRR MDRAAQLAVV TAREAAADSG LEFAGLPPHR VGVTVGSAVG ATTGLDQEYR
TVSDGGRLEL VDHEYAVPHL YNYFVPSSFA AEVAWTVGAG GPVSVVSTGC TSGLDAVGHA
TELIREGSAD VVLAGATDAP ISPITVACFD AIKATTPRND DPEHASRPFD GTRNGFVLGE
GSAMFVLEEL ESARRRGAQV YAEVAGFASR CNAYHMTGLR PDGREMAEAI RVALGEARLA
PDAVDYVNAH GSGTRQNDRH ETAAFKLSLG EHAHRVPISS VKSMVGHSLG AIGSIEVAAS
VLAMRENVVP PTANLHIADP ECDLDYVPVT AREHRTDTVL SVGSGFGGFQ SAIVLTRPGA
AA
//
