ID   D7SC44_9REOV            Unreviewed;       172 AA.
AC   D7SC44;
DT   10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT   10-AUG-2010, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   SubName: Full=Nonstructural protein 4 {ECO:0000313|EMBL:ADI61937.1};
DE   Flags: Fragment;
OS   Human rotavirus A.
OC   Viruses; Riboviria; Orthornavirae; Duplornaviricota; Resentoviricetes;
OC   Reovirales; Sedoreoviridae; Rotavirus; Rotavirus A.
OX   NCBI_TaxID=10941 {ECO:0000313|EMBL:ADI61937.1};
RN   [1] {ECO:0000313|EMBL:ADI61937.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=PR1759/2005 {ECO:0000313|EMBL:ADI61937.1};
RX   PubMed=21525221; DOI=10.1128/JCM.01358-10;
RA   Medici M.C., Abelli L.A., Martinelli M., Corradi D., Dodi I., Tummolo F.,
RA   Albonetti V., Martella V., Dettori G., Chezzi C.;
RT   "Clinical and molecular observations of two fatal cases of rotavirus-
RT   associated enteritis in children in Italy.";
RL   J. Clin. Microbiol. 49:2733-2739(2011).
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DR   EMBL; HM245012; ADI61937.1; -; Genomic_RNA.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.5.430; -; 1.
DR   HAMAP; MF_04091; ROTA_NSP4; 1.
DR   InterPro; IPR002107; Rotavirus_NSP4.
DR   Pfam; PF01452; Rota_NSP4; 1.
DR   SUPFAM; SSF58030; Rotavirus nonstructural proteins; 1.
PE   3: Inferred from homology;
KW   Activation of host autophagy by virus {ECO:0000256|ARBA:ARBA00023050};
KW   Calcium {ECO:0000256|ARBA:ARBA00022837};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Enterotoxin {ECO:0000256|ARBA:ARBA00022861};
KW   Host-virus interaction {ECO:0000256|ARBA:ARBA00023050};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Toxin {ECO:0000256|ARBA:ARBA00022656};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        26..43
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   COILED          82..109
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:ADI61937.1"
FT   NON_TER         172
FT                   /evidence="ECO:0000313|EMBL:ADI61937.1"
SQ   SEQUENCE   172 AA;  19885 MW;  FFFBE0E31D0F73BC CRC64;
     LADLNYTLSV ITLMNDTLHS IIQDPGMAYF PYIASVLTVL FTLHKASIPT MKIALKTSKC
     SYKVIKYCIV TIINTLLKLA GYKEQVTTKD EIEQQMDRIV KEMRRQLEMI DKLTTREIEQ
     VELLKRIHDS LITRPVDVID MTKEFNQKNI KTLDEWESGK NPYEPIEVTA SM
//