GenomeNet

Database: UniProt
Entry: D7W947_9CORY
LinkDB: D7W947_9CORY
Original site: D7W947_9CORY 
ID   D7W947_9CORY            Unreviewed;       533 AA.
AC   D7W947;
DT   05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2010, sequence version 1.
DT   25-OCT-2017, entry version 45.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377,
GN   ECO:0000313|EMBL:EFK55327.1};
GN   ORFNames=HMPREF0291_10585 {ECO:0000313|EMBL:EFK55327.1};
OS   Corynebacterium genitalium ATCC 33030.
OC   Bacteria; Actinobacteria; Corynebacteriales; Corynebacteriaceae;
OC   Corynebacterium.
OX   NCBI_TaxID=585529 {ECO:0000313|EMBL:EFK55327.1, ECO:0000313|Proteomes:UP000004208};
RN   [1] {ECO:0000313|EMBL:EFK55327.1, ECO:0000313|Proteomes:UP000004208}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 33030 {ECO:0000313|EMBL:EFK55327.1,
RC   ECO:0000313|Proteomes:UP000004208};
RA   Muzny D., Qin X., Buhay C., Dugan-Rocha S., Ding Y., Chen G.,
RA   Hawes A., Holder M., Jhangiani S., Johnson A., Khan Z., Li Z., Liu W.,
RA   Liu X., Perez L., Shen H., Wang Q., Watt J., Xi L., Xin Y., Zhou J.,
RA   Deng J., Jiang H., Liu Y., Qu J., Song X.-Z., Zhang L., Villasana D.,
RA   Johnson A., Liu J., Liyanage D., Lorensuhewa L., Robinson T., Song A.,
RA   Song B.-B., Dinh H., Thornton R., Coyle M., Francisco L., Jackson L.,
RA   Javaid M., Korchina V., Kovar C., Mata R., Mathew T., Ngo R.,
RA   Nguyen L., Nguyen N., Okwuonu G., Ongeri F., Pham C., Simmons D.,
RA   Wilczek-Boney K., Hale W., Jakkamsetti A., Pham P., Ruth R.,
RA   San Lucas F., Warren J., Zhang J., Zhao Z., Zhou C., Zhu D., Lee S.,
RA   Bess C., Blankenburg K., Forbes L., Fu Q., Gubbala S., Hirani K.,
RA   Jayaseelan J.C., Lara F., Munidasa M., Palculict T., Patil S.,
RA   Pu L.-L., Saada N., Tang L., Weissenberger G., Zhu Y., Hemphill L.,
RA   Shang Y., Youmans B., Ayvaz T., Ross M., Santibanez J., Aqrawi P.,
RA   Gross S., Joshi V., Fowler G., Nazareth L., Reid J., Worley K.,
RA   Petrosino J., Highlander S., Gibbs R.;
RL   Submitted (JUN-2010) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00735475}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00911680}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:EFK55327.1}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; ACLJ02000001; EFK55327.1; -; Genomic_DNA.
DR   RefSeq; WP_005287692.1; NZ_CM000961.1.
DR   ProteinModelPortal; D7W947; -.
DR   STRING; 585529.HMPREF0291_10585; -.
DR   EnsemblBacteria; EFK55327; EFK55327; HMPREF0291_10585.
DR   eggNOG; ENOG4105CI4; Bacteria.
DR   eggNOG; COG0593; LUCA.
DR   OrthoDB; POG091H02FF; -.
DR   Proteomes; UP000004208; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747950};
KW   Complete proteome {ECO:0000313|Proteomes:UP000004208};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00911664};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00747996};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00911684};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747895};
KW   Reference proteome {ECO:0000313|Proteomes:UP000004208}.
FT   DOMAIN      224    352       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      436    505       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     232    239       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   533 AA;  59954 MW;  D564F7EE834B75AF CRC64;
     MAFDQQALDA LWQDVVTELL NLSERPNSPV PTFTPGDRAY LRLVRPVMLV EGYCILSVPH
     SAAKNVVENQ LGPYIVEILT HHLNRPCNIA VSVDAAAPEP APEPEPPVQH TAPNPTPWFP
     TYSEQARQFP APIAGEQLPM GLDELARIHA QQQEQHAIEE SARQQAAHPV VEVPQRIQRE
     KPAHDPNRET SLNPKYTFEN FVIGSSNRFA NGAAVAVAEN PARAYNPLFI WGGSGLGKTH
     LLHAAGNYSR VLQPDLRIKY VSSEEFTNDY INSVRDDRQE SFKRRYRDLD ILMVDDIQFL
     EGKEGTQEEF FHTFNALHQA NKQIILSSDR PPKQLTTLED RLRTRFEGGL ITDVQPPDLE
     TRIAILMKKA AADGTQVDDE VLELIASKFE SSIRELEGAL IRVSAYSSLI KEPITLDVAQ
     IALRDILPDE GDIKITATTI KEVAAEYFRV SLDKLTGAGK TRTVAHARQL AMYLCRELTD
     LSLPKIGQEF GGKDHTTVMY ADRKIRKEMT ENRETYDEIQ ELTQIIKTRV RSQ
//
DBGET integrated database retrieval system