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Database: UniProt
Entry: D8A7M9_ECOMS
LinkDB: D8A7M9_ECOMS
Original site: D8A7M9_ECOMS 
ID   D8A7M9_ECOMS            Unreviewed;       181 AA.
AC   D8A7M9;
DT   05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2010, sequence version 1.
DT   24-JAN-2024, entry version 51.
DE   RecName: Full=Leucine-responsive regulatory protein {ECO:0000256|ARBA:ARBA00039227};
GN   Name=lrp {ECO:0000313|EMBL:EFK20840.1};
GN   ORFNames=HMPREF9530_02533 {ECO:0000313|EMBL:EFK20840.1};
OS   Escherichia coli (strain MS 21-1).
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=749527 {ECO:0000313|EMBL:EFK20840.1, ECO:0000313|Proteomes:UP000005688};
RN   [1] {ECO:0000313|EMBL:EFK20840.1, ECO:0000313|Proteomes:UP000005688}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MS 21-1 {ECO:0000313|EMBL:EFK20840.1,
RC   ECO:0000313|Proteomes:UP000005688};
RA   Weinstock G., Sodergren E., Clifton S., Fulton L., Fulton B., Courtney L.,
RA   Fronick C., Harrison M., Strong C., Farmer C., Delahaunty K., Markovic C.,
RA   Hall O., Minx P., Tomlinson C., Mitreva M., Hou S., Chen J., Wollam A.,
RA   Pepin K.H., Johnson M., Bhonagiri V., Zhang X., Suruliraj S., Warren W.,
RA   Chinwalla A., Mardis E.R., Wilson R.K.;
RL   Submitted (JUN-2010) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Mediates a global response to leucine. Exogenous leucine
CC       affects the expression of a number of different operons; lrp mediates
CC       this effect for at least some of these operons. For example it is
CC       regulator of the branched-chain amino acid transport genes.
CC       {ECO:0000256|ARBA:ARBA00037041}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EFK20840.1}.
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DR   EMBL; ADTR01000245; EFK20840.1; -; Genomic_DNA.
DR   AlphaFoldDB; D8A7M9; -.
DR   HOGENOM; CLU_091233_0_0_6; -.
DR   Proteomes; UP000005688; Unassembled WGS sequence.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   CDD; cd00090; HTH_ARSR; 1.
DR   Gene3D; 3.30.70.920; -; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR011991; ArsR-like_HTH.
DR   InterPro; IPR000485; AsnC-type_HTH_dom.
DR   InterPro; IPR011008; Dimeric_a/b-barrel.
DR   InterPro; IPR019888; Tscrpt_reg_AsnC-like.
DR   InterPro; IPR019887; Tscrpt_reg_AsnC/Lrp_C.
DR   InterPro; IPR019885; Tscrpt_reg_HTH_AsnC-type_CS.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR30154; LEUCINE-RESPONSIVE REGULATORY PROTEIN; 1.
DR   PANTHER; PTHR30154:SF0; LEUCINE-RESPONSIVE REGULATORY PROTEIN; 1.
DR   Pfam; PF01037; AsnC_trans_reg; 1.
DR   Pfam; PF13412; HTH_24; 1.
DR   PRINTS; PR00033; HTHASNC.
DR   SMART; SM00344; HTH_ASNC; 1.
DR   SUPFAM; SSF54909; Dimeric alpha+beta barrel; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS00519; HTH_ASNC_1; 1.
DR   PROSITE; PS50956; HTH_ASNC_2; 1.
PE   4: Predicted;
KW   Activator {ECO:0000256|ARBA:ARBA00023159};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT   DOMAIN          29..90
FT                   /note="HTH asnC-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50956"
SQ   SEQUENCE   181 AA;  20826 MW;  05ACA826FF3630C2 CRC64;
     MFQGQTGVGK EYRETIIMVD SKKRPGKDLD RIDRNILNEL QKDGRISNVE LSKRVGLSPT
     PCLERVRRLE RQGFIQGYTA LLNPHYLDAS LLVFVEITLN RGAPDVFEQF NTAVQKLEEI
     QECHLVSGDF DYLLKTRVPD MSAYRKLLGE TLLRLPGVND TRTYVVMEEV KQSNRLVIKT
     R
//
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