ID   D8EZS0_9DELT            Unreviewed;      1023 AA.
AC   D8EZS0;
DT   05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2010, sequence version 1.
DT   27-MAR-2024, entry version 39.
DE   SubName: Full=Adenylate and Guanylate cyclase catalytic domain protein {ECO:0000313|EMBL:EFK11009.1};
GN   ORFNames=NPH_4997 {ECO:0000313|EMBL:EFK11009.1};
OS   delta proteobacterium NaphS2.
OC   Bacteria; Deltaproteobacteria.
OX   NCBI_TaxID=88274 {ECO:0000313|EMBL:EFK11009.1, ECO:0000313|Proteomes:UP000003834};
RN   [1] {ECO:0000313|EMBL:EFK11009.1, ECO:0000313|Proteomes:UP000003834}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NaphS2 {ECO:0000313|EMBL:EFK11009.1,
RC   ECO:0000313|Proteomes:UP000003834};
RX   PubMed=21124915; DOI=10.1371/journal.pone.0014072;
RA   Didonato R.J., Young N.D., Butler J.E., Chin K.J., Hixson K.K., Mouser P.,
RA   Lipton M.S., Deboy R., Methe B.A.;
RT   "Genome Sequence of the Deltaproteobacterial Strain NaphS2 and Analysis of
RT   Differential Gene Expression during Anaerobic Growth on Naphthalene.";
RL   PLoS ONE 5:E14072-E14072(2010).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EFK11009.1}.
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DR   EMBL; ADZZ01000144; EFK11009.1; -; Genomic_DNA.
DR   AlphaFoldDB; D8EZS0; -.
DR   OrthoDB; 9806735at2; -.
DR   Proteomes; UP000003834; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProt.
DR   GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd07302; CHD; 1.
DR   Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR   InterPro; IPR001054; A/G_cyclase.
DR   InterPro; IPR007890; CHASE2.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   PANTHER; PTHR43081:SF16; ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC; 1.
DR   PANTHER; PTHR43081; ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC-RELATED; 1.
DR   Pfam; PF05226; CHASE2; 1.
DR   Pfam; PF00211; Guanylate_cyc; 1.
DR   SMART; SM01080; CHASE2; 1.
DR   SMART; SM00044; CYCc; 1.
DR   SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR   PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000003834};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        606..623
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        630..649
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        655..676
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          718..877
FT                   /note="Guanylate cyclase"
FT                   /evidence="ECO:0000259|PROSITE:PS50125"
SQ   SEQUENCE   1023 AA;  115968 MW;  4587D9194EA7988B CRC64;
     MLKKAVIVLL IGLSVFAVMH FISSKTRLFL GIERNLLNGL FFLREPEVHE TNPLVSQEVI
     LLGFDEDAIA SIGKWPWKRD VHARMLNNLE KFSPRTVMFD VVFVKNETIP PFLSKKLTPE
     PKLLLKVEKA FNEMDQAFAE ALKEYNNVFL DVQLVENPRP DLPKAYLNRI FFNEQILKDY
     SLPLKNNQSL LVFHSLEPVL SEFISSAHPA IVNVLADDDD VTRMFPLYYT YKMSDGTVRN
     LFTATLLLVK QYYRVHNEDI SITPDRIVLS NAKIPILDPL THQLHVFEKD FNWVKHKILN
     PVAPEGYPYN QNLFRLLLNR LKMKIAFDKK PAPFPIHVLK GTGGFEILEG WEVFDAAREG
     KAETVQFVVY EKGTIEINTP VPGFSYINYA GTEKRYIMDE KTGVPKIYTT VPTKSYGNVH
     AMASLPEIPL LNASGRIEAD YETRPLEKWY MAFCEKRSYT AYHQAAGDLG DDVQDDVRLK
     DYLNRNSEIG KYFFYSYYFS NADAPAGMLR ALIEQYPGFG TEIGQDPADF LTDERVVQDL
     MATYMDQFQL YYHKFVFAGA TARILGDIQQ TPYGAMNGIN TLINAFNTII TQNQLTFSAH
     VPNLDLLLLL GLCLFCSFAY GFTSIRFSSV IFILLVLGTL TISFALFSIK NLVLTTTPLV
     FSNVLIFGGI IVLKVLTEQK DKKFLKTTFS SYLAPEIIDE MYRNKTMPTL GGEARPITAY
     FTDIQGFSTF SEKLTADQLV ELINEYLSAM TDILIGNMGT LDKYEGDAII AFFGAPMDVP
     DHALRACRVA VSMQGKLAEL RRKWAKEKQD SHEPNRNTKG LAAHEWKTGD KWPLIVHSMK
     MRIGINTGEI VVGNMGSAMR MNYTMMGDPV NLAARLEEAG KQYGVFILVS EDTLKCEIAD
     DRGTLKQVFD MVEVRFIDTI AVVGKSEPVR VYELCAMKGG LTANEKELIA VFDRAMGHYL
     KMNWNGAIRD FEKASNMERI PDGKTTPSTT PSRVYMDRCR TYKENPPVAP GEVWDGVCRL
     TKK
//