ID D8FWT4_9CYAN Unreviewed; 417 AA.
AC D8FWT4;
DT 05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2010, sequence version 1.
DT 24-JAN-2024, entry version 55.
DE SubName: Full=Precorrin-6Y C(5,15)-methyltransferase (Decarboxylating) {ECO:0000313|EMBL:CBN54824.1};
DE EC=2.1.1.132 {ECO:0000313|EMBL:CBN54824.1};
GN Name=cobL {ECO:0000313|EMBL:CBN54824.1};
GN ORFNames=OSCI_1100003 {ECO:0000313|EMBL:CBN54824.1};
OS Kamptonema sp. PCC 6506.
OC Bacteria; Cyanobacteriota; Cyanophyceae; Oscillatoriophycideae;
OC Oscillatoriales; Microcoleaceae; Kamptonema.
OX NCBI_TaxID=272129 {ECO:0000313|EMBL:CBN54824.1, ECO:0000313|Proteomes:UP000004532};
RN [1] {ECO:0000313|EMBL:CBN54824.1, ECO:0000313|Proteomes:UP000004532}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PCC 6506 {ECO:0000313|EMBL:CBN54824.1,
RC ECO:0000313|Proteomes:UP000004532};
RX PubMed=20675499; DOI=10.1128/JB.00704-10;
RA Mejean A., Mazmouz R., Mann S., Calteau A., Medigue C., Ploux O.;
RT "The genome sequence of the cyanobacterium Oscillatoria sp. PCC 6506
RT reveals several gene clusters responsible for the biosynthesis of toxins
RT and secondary metabolites.";
RL J. Bacteriol. 192:5264-5265(2010).
CC -!- PATHWAY: Cofactor biosynthesis; adenosylcobalamin biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004953}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CBN54824.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CACA01000106; CBN54824.1; -; Genomic_DNA.
DR RefSeq; WP_007354047.1; NZ_CACA01000106.1.
DR AlphaFoldDB; D8FWT4; -.
DR OrthoDB; 9780707at2; -.
DR UniPathway; UPA00148; -.
DR Proteomes; UP000004532; Unassembled WGS sequence.
DR GO; GO:0046025; F:precorrin-6Y C5,15-methyltransferase (decarboxylating) activity; IEA:UniProtKB-EC.
DR GO; GO:0008276; F:protein methyltransferase activity; IEA:InterPro.
DR GO; GO:0009236; P:cobalamin biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd02440; AdoMet_MTases; 1.
DR CDD; cd11644; Precorrin-6Y-MT; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR000878; 4pyrrol_Mease.
DR InterPro; IPR035996; 4pyrrol_Methylase_sf.
DR InterPro; IPR014777; 4pyrrole_Mease_sub1.
DR InterPro; IPR012818; CbiE.
DR InterPro; IPR006365; Cbl_synth_CobL.
DR InterPro; IPR014008; Cbl_synth_MTase_CbiT.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR NCBIfam; TIGR02467; CbiE; 1.
DR NCBIfam; TIGR02469; CbiT; 1.
DR PANTHER; PTHR43182; COBALT-PRECORRIN-6B C(15)-METHYLTRANSFERASE (DECARBOXYLATING); 1.
DR PANTHER; PTHR43182:SF1; COBALT-PRECORRIN-7 C(5)-METHYLTRANSFERASE; 1.
DR Pfam; PF00590; TP_methylase; 1.
DR PIRSF; PIRSF036428; CobL; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR SUPFAM; SSF53790; Tetrapyrrole methylase; 1.
PE 4: Predicted;
KW Cobalamin biosynthesis {ECO:0000256|ARBA:ARBA00022573};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:CBN54824.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000004532};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:CBN54824.1}.
FT DOMAIN 19..200
FT /note="Tetrapyrrole methylase"
FT /evidence="ECO:0000259|Pfam:PF00590"
SQ SEQUENCE 417 AA; 44668 MW; 5264201B28805E73 CRC64;
MTSQVSTQSL IPSPQQKWLS VVGIGEDGLS GLSAIAQSLI DRAKIIVGGA RHLAMLPKDD
REKLVWASPI EATIDEIIRR QGQPVCILAS GDPMCHGIGV TLTRRIPISQ ITIIPAASAF
SLACARLGWP LAEIETFSLT NRPIAAIASA FYPGARLLVL SADKHTPAKV AAMLTERGFG
DSQIAILERM GGELERVIEG IAATWEATDL ADLNTIAMAV IATPGTFPLP RISGLPDIAF
HHDGQLTKRE VRAITLSTLA PIPGELLWDV GAGCGSIAIE WMRSHRHCRA IAIERHQTRL
QYIADNAAAL GVPSLKIVAG EAPEALKDLP QPDAVFIGGG ATTDTLFETC WNALRSHGRL
VVNAVTIESE LKVLQWHSEY GGELIRISID RTVAIGSFLG WKPSAPITQW IAVKPAS
//
