ID D8G017_9CYAN Unreviewed; 470 AA.
AC D8G017;
DT 05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2010, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE SubName: Full=Adenylate and Guanylate cyclase catalytic domain protein {ECO:0000313|EMBL:CBN55957.1};
GN ORFNames=OSCI_2590012 {ECO:0000313|EMBL:CBN55957.1};
OS Kamptonema sp. PCC 6506.
OC Bacteria; Cyanobacteriota; Cyanophyceae; Oscillatoriophycideae;
OC Oscillatoriales; Microcoleaceae; Kamptonema.
OX NCBI_TaxID=272129 {ECO:0000313|EMBL:CBN55957.1, ECO:0000313|Proteomes:UP000004532};
RN [1] {ECO:0000313|Proteomes:UP000004532}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PCC 6506 {ECO:0000313|Proteomes:UP000004532};
RX PubMed=20675499; DOI=10.1128/JB.00704-10;
RA Mejean A., Mazmouz R., Mann S., Calteau A., Medigue C., Ploux O.;
RT "The genome sequence of the cyanobacterium Oscillatoria sp. PCC 6506
RT reveals several gene clusters responsible for the biosynthesis of toxins
RT and secondary metabolites.";
RL J. Bacteriol. 192:5264-5265(2010).
CC -!- SIMILARITY: Belongs to the adenylyl cyclase class-4/guanylyl cyclase
CC family. {ECO:0000256|RuleBase:RU000405}.
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DR EMBL; CACA01000225; CBN55957.1; -; Genomic_DNA.
DR RefSeq; WP_007355172.1; NZ_CACA01000225.1.
DR AlphaFoldDB; D8G017; -.
DR OrthoDB; 456159at2; -.
DR Proteomes; UP000004532; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProt.
DR GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd07302; CHD; 1.
DR CDD; cd06225; HAMP; 1.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR018297; A/G_cyclase_CS.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR PANTHER; PTHR11920:SF335; GUANYLATE CYCLASE 32E; 1.
DR PANTHER; PTHR11920; GUANYLYL CYCLASE; 1.
DR Pfam; PF00211; Guanylate_cyc; 1.
DR SMART; SM00044; CYCc; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR PROSITE; PS00452; GUANYLATE_CYCLASE_1; 1.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
PE 3: Inferred from homology;
KW Lyase {ECO:0000256|RuleBase:RU000405};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000004532};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 20..41
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 168..193
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 295..422
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
SQ SEQUENCE 470 AA; 52786 MW; 3E4DF19DAC96C784 CRC64;
MKPRILTLLG SFKARLSLRV TFWVFVSLII IELIILVPSY FRREDELLLQ LEQVSNASIN
SLVVLTKTDM SDRDLFRTKV KNIITNSNII SGIAIYKVNG EPIDTLGEAP EISFSELKNA
KILRRRSRDG FRYDVAWTNL HLGGNYILIV RHDATSVQQE LYAFTLRIAG LVLIISIFVT
SGTMVVLGIT VIAPILRLRD DLIAAGDALS KNESKPDFYS LSVKRKDELG EVMEAFNQMF
NRVYQEINQR KKAEEILRSE QEKSERLLLN ILPEPIAERL KQGQSNIADG FADVTILFAD
IVGFTEISSR VSPQELVDLL NKIFSAFDEL SEKYCLEKIK TIGDNYMVAA GLPVPHPDHA
EAIAEMALDM QQEIVRFSIE CGKPLNIRIG INSGPVVAGV IGTKKFIYDL WGDAVNTASR
MESQGIPGKI QVSASTYYLL QNKYLFEERG IIQVKGKGEM TTYLLTGRKV
//
